First Iron(II) Organometallic Compound Acting as ABCB1 Inhibitor

Autor: Adhan Pilon, Fernando Avecilla, Miklós Mohai, Éva A. Enyedy, Bálint Rácz, Gabriella Spengler, M. Helena Garcia, Andreia Valente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac510c7debaf43d1dce4fd88a1cdfe4
https://doi.org/10.2139/ssrn.4403244

Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs

Autor: Andreia Valente, M. Helena Garcia

Publikováno v: Inorganics, Vol 2, Iss 1, Pp 96-114 (2014)

The continuous rising of the cancer patient death rate undoubtedly shows the pressure to find more potent and efficient drugs than those in clinical use. These agents only treat a narrow range of cancer conditions with limited success and are associa

Externí odkaz: https://doaj.org/article/ede2411eb7c1471d9983210537d3658d

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand

Autor: Cathleen Doherty, Brian Buckley, Fernanda Marques, M. Helena Garcia, Leonor Côrte-Real, Patrícia Gírio, Alexis Moreno, Andreia Valente, Pierre Falson, Keith R. Cooper, Fernando Avecilla, Brittany F Karas

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 163, pp.853-863. ⟨10.1016/j.ejmech.2018.12.022⟩

International audience; Two new ruthenium complexes, [Ru(h 5-Cp)(PPh 3)(2,2'-bipy-4,4'-R)] þ with R ¼-CH 2 OH (Ru1) or dibiotin ester (Ru2) were synthesized and fully characterized. Both compounds were tested against two types of breast cancer cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd399c16284d8151c87ae642f1d0dd9
https://doi.org/10.1016/j.ejmech.2018.12.022

Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds

Autor: Ricardo G. Teixeira, M. Helena Garcia, Chiara Riganti, Xavier Fontrodona, Isabel Romero, Ana Isabel Tomaz, Andreia Valente, Dimas Carolina Belisario

Publikováno v: Inorganic Chemistry Frontiers, 2021, vol. 8, p. 1983-1996
Articles publicats (D-Q)
Teixeira, Ricardo G. Belisario, Dimas C. Fontrodona, Xavier Romero García, Isabel Tomaz, Ana Isabel Garcia, M.Helena Riganti, Chiara Valente, Andreia 2021 Unprecedented collateral sensitivity for cisplatinresistant lung cancer cells presented by new ruthenium organometallic compounds Inorganic Chemistry Frontiers 8 1983 1996
DUGiDocs – Universitat de Girona
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Platinum-based therapies continue to be the main regimen used to treat non-small cell lung cancers (NSCLC), where multidrug resistance plays a key role in treatment failure and strategies to overcome this limitation are urgently sought for. In view t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9898364b95bdee9d33021f7cb1239703
http://hdl.handle.net/2318/1795304

Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents

Autor: Andreia Valente, Tânia S. Morais, Cristina P. Matos, Ana Isabel Tomaz, M. Helena Garcia, Ricardo G. Teixeira

In this chapter we address the development of ruthenium- and iron-based metallodrugs as prospective chemotherapeutics in cancer treatment. We provide an overview of the field addressing iron and ruthenium complexes reported as promising anticancer me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0836f2aca5cc6b5394ac930bc1579562
https://doi.org/10.1016/b978-0-12-818429-5.00010-7