Zobrazeno 1 - 10
of 111
pro vyhledávání: '"M Helena, Garcia"'
Autor:
Leonor Côrte-Real, Ana Rita Brás, Adhan Pilon, Nuno Mendes, Ana Sofia Ribeiro, Tiago D. Martins, José Paulo S. Farinha, M. Conceição Oliveira, Fátima Gärtner, M. Helena Garcia, Ana Preto, Andreia Valente
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1388 (2022)
The need for new therapeutic approaches for triple-negative breast cancer is a clinically relevant problem that needs to be solved. Using a multi-targeting approach to enhance cancer cell uptake, we synthesized a new family of ruthenium(II) organomet
Externí odkaz:
https://doaj.org/article/288abacbd54c421c85e6044ef7572fda
Autor:
Adhan Pilon, Ana Rita Brás, Leonor Côrte-Real, Fernando Avecilla, Paulo J. Costa, Ana Preto, M. Helena Garcia, Andreia Valente
Publikováno v:
Molecules, Vol 25, Iss 7, p 1592 (2020)
A family of compounds with the general formula [Fe(η5-C5H5)(CO)(PPh3)(NCR)]+ has been synthesized (NCR = benzonitrile (1); 4-hydroxybenzonitrile (2); 4-hydroxymethylbenzonitrile (3); 4-aminobenzonitrile (4); 4-bromobenzonitrile (5); and, 4-chlorocin
Externí odkaz:
https://doaj.org/article/13705ff2ed634604983942486faea1e0
Publikováno v:
BioMetals. 34:1029-1042
The interaction between human serum transferrin (hTf) and three promising organometallic Ru (II)- (η5-C5H5) derived complexes, that have already shown strong in vitro cytotoxicity towards human cancer cell lines, has been investigated using fluoresc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50facf2a3d1514fe4bfd06f74641e149
https://doi.org/10.1007/s10534-021-00325-w
https://doi.org/10.1007/s10534-021-00325-w
Autor:
Andreia Valente, M. Helena Garcia
Publikováno v:
Inorganics, Vol 2, Iss 1, Pp 96-114 (2014)
The continuous rising of the cancer patient death rate undoubtedly shows the pressure to find more potent and efficient drugs than those in clinical use. These agents only treat a narrow range of cancer conditions with limited success and are associa
Externí odkaz:
https://doaj.org/article/ede2411eb7c1471d9983210537d3658d
Autor:
Cathleen Doherty, Brian Buckley, Fernanda Marques, M. Helena Garcia, Leonor Côrte-Real, Patrícia Gírio, Alexis Moreno, Andreia Valente, Pierre Falson, Keith R. Cooper, Fernando Avecilla, Brittany F Karas
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 163, pp.853-863. ⟨10.1016/j.ejmech.2018.12.022⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 163, pp.853-863. ⟨10.1016/j.ejmech.2018.12.022⟩
International audience; Two new ruthenium complexes, [Ru(h 5-Cp)(PPh 3)(2,2'-bipy-4,4'-R)] þ with R ¼-CH 2 OH (Ru1) or dibiotin ester (Ru2) were synthesized and fully characterized. Both compounds were tested against two types of breast cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd399c16284d8151c87ae642f1d0dd9
https://doi.org/10.1016/j.ejmech.2018.12.022
https://doi.org/10.1016/j.ejmech.2018.12.022
Publikováno v:
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 34(5)
The interaction between human serum transferrin (hTf) and three promising organometallic Ru (II)- (η
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a11a2bf864879c382e3df67e0c1cd98d
https://pubmed.ncbi.nlm.nih.gov/34155581
https://pubmed.ncbi.nlm.nih.gov/34155581
Autor:
Carlos Alonso-Moreno, Christopher B. Caputo, José A. Castro-Osma, Simon Duttwyler, M. Helena Garcia, Mustapha Hamdaoui, Helena Henke, Okan Icten, Aitziber Iturmendi, Anukul Jana, Katie J. Lamb, Agustín Lara-Sánchez, Di Li, Fan Liu, Shengqian Ma, Cristina P. Matos, Meera Mehta, Tânia S. Morais, Michael North, George S. Pappas, Jizeng Sun, Qi Sun, Ian Teasdale, Ricardo G. Teixeira, Ana Isabel Tomaz, Andreia Valente, Rajesh Varkhedkar, Stephan E. Wolf, Xiao Wu, Wenjun Zheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4201d7e2a458be39dd32658d002da0f0
https://doi.org/10.1016/b978-0-12-818429-5.00013-2
https://doi.org/10.1016/b978-0-12-818429-5.00013-2
Autor:
Andreia Valente, Tânia S. Morais, Cristina P. Matos, Ana Isabel Tomaz, M. Helena Garcia, Ricardo G. Teixeira
In this chapter we address the development of ruthenium- and iron-based metallodrugs as prospective chemotherapeutics in cancer treatment. We provide an overview of the field addressing iron and ruthenium complexes reported as promising anticancer me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0836f2aca5cc6b5394ac930bc1579562
https://doi.org/10.1016/b978-0-12-818429-5.00010-7
https://doi.org/10.1016/b978-0-12-818429-5.00010-7
Autor:
Ricardo G. Teixeira, M. Helena Garcia, Chiara Riganti, Xavier Fontrodona, Isabel Romero, Ana Isabel Tomaz, Andreia Valente, Dimas Carolina Belisario
Publikováno v:
Inorganic Chemistry Frontiers, 2021, vol. 8, p. 1983-1996
Articles publicats (D-Q)
Teixeira, Ricardo G. Belisario, Dimas C. Fontrodona, Xavier Romero García, Isabel Tomaz, Ana Isabel Garcia, M.Helena Riganti, Chiara Valente, Andreia 2021 Unprecedented collateral sensitivity for cisplatinresistant lung cancer cells presented by new ruthenium organometallic compounds Inorganic Chemistry Frontiers 8 1983 1996
DUGiDocs – Universitat de Girona
instname
Articles publicats (D-Q)
Teixeira, Ricardo G. Belisario, Dimas C. Fontrodona, Xavier Romero García, Isabel Tomaz, Ana Isabel Garcia, M.Helena Riganti, Chiara Valente, Andreia 2021 Unprecedented collateral sensitivity for cisplatinresistant lung cancer cells presented by new ruthenium organometallic compounds Inorganic Chemistry Frontiers 8 1983 1996
DUGiDocs – Universitat de Girona
instname
Platinum-based therapies continue to be the main regimen used to treat non-small cell lung cancers (NSCLC), where multidrug resistance plays a key role in treatment failure and strategies to overcome this limitation are urgently sought for. In view t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9898364b95bdee9d33021f7cb1239703
http://hdl.handle.net/2318/1795304
http://hdl.handle.net/2318/1795304