Zobrazeno 1 - 10 of 16 pro vyhledávání: '"M Helen Rajpar"'
1
Akademický článek
Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.
Autor: Louise H W Kung, M Helen Rajpar, Richard Preziosi, Michael D Briggs, Raymond P Boot-Handford
Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0117016 (2015)
Mutations in genes encoding cartilage oligomeric matrix protein and matrilin-3 cause a spectrum of chondrodysplasias called multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH). The majority of these diseases feature classical endopla
Externí odkaz: https://doaj.org/article/dd5c17f983e44dffa4ba9f6b5e564e6c
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2
Akademický článek
Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy.
Autor: Trevor L Cameron, Katrina M Bell, Liliana Tatarczuch, Eleanor J Mackie, M Helen Rajpar, Ben T McDermott, Raymond P Boot-Handford, John F Bateman
Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24600 (2011)
Metaphyseal chondrodysplasia, Schmid type (MCDS) is characterized by mild short stature and growth plate hypertrophic zone expansion, and caused by collagen X mutations. We recently demonstrated the central importance of ER stress in the pathology of
Externí odkaz: https://doaj.org/article/f14e4edc89bb4cd0851d1139fa726847
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3
Akademický článek
Targeted induction of endoplasmic reticulum stress induces cartilage pathology.
Autor: M Helen Rajpar, Ben McDermott, Louise Kung, Rachel Eardley, Lynette Knowles, Mel Heeran, David J Thornton, Richard Wilson, John F Bateman, Richard Poulsom, Peter Arvan, Karl E Kadler, Michael D Briggs, Raymond P Boot-Handford
Publikováno v: PLoS Genetics, Vol 5, Iss 10, p e1000691 (2009)
Pathologies caused by mutations in extracellular matrix proteins are generally considered to result from the synthesis of extracellular matrices that are defective. Mutations in type X collagen cause metaphyseal chondrodysplasia type Schmid (MCDS), a
Externí odkaz: https://doaj.org/article/7462bf70f27043b287d249eb89c6cc09
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5
A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth
Autor: Peter Arvan, Benedetta Gualeni, M. Helen Rajpar, Michael D. Briggs, Aaron P. Kellogg, Raymond P. Boot-Handford, Peter A. Bell
Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1414-1425 (2013)
Disease Models & Mechanisms
SummaryDisease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival. Delineating the relative contrib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35727309304ca3b71213905fb763e9d0
http://dmm.biologists.org/content/6/6/1414
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7
Hypertrophic Chondrocytes Have a Limited Capacity to Cope with Increases in Endoplasmic Reticulum Stress without Triggering the Unfolded Protein Response
Autor: M. Helen Rajpar, Louise H. W. Kung, Raymond P. Boot-Handford, Michael D. Briggs
Publikováno v: Journal of Histochemistry and Cytochemistry
Mutations causing metaphyseal chondrodysplasia type Schmid (MCDS) (e.g., Col10a1p.N617K) induce the pathology by a mechanism involving increased endoplasmic reticulum (ER) stress triggering an unfolded protein response (UPR) in hypertrophic chondrocy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28050073abc402eac52d90c543a5aca8
https://doi.org/10.1369/0022155412458436
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8
List of Contributors
Autor: Omar M.E. Albagha, Andrew Arnold, Paul Baldock, Mary L. Bouxsein, Brendan F. Boyce, Stephanie Jo Brewster, Edward M. Brown, Matthew A. Brown, David A. Bushinsky, Salin A. Chakkalakal, Roderick Clifton-Bligh, William G. Cole, Michael T. Collins, Michael R. Convente, Jessica Costa-Guda, Andria L. Culbert, Hong-Wen Deng, Olivier Devuyst, Marc K. Drezner, Emma L. Duncan, Ogo I. Egbuna, John A. Eisman, David Feldman, Mathieu Ferron, Matti Gild, Yan Guo, Kilian Guse, Ingrid A. Holm, Bryan Hudson, Takashi Igarashi, Christina Jacobsen, Harald Jüppner, Frederick S. Kaplan, Gerard Karsenty, Christopher S. Kovacs, Brendan Lee, Gabriela G. Loots, Rik J. Lories, Vitali Y. Lounev, Frank P. Luyten, Peter J. Malloy, Joan C. Marini, T. John Martin, Walter L. Miller, Orson W. Moe, Tuan V. Nguyen, Franck Oury, Christopher J. Papasian, Dhruval Patel, Bram Perdu, Siân E. Piret, M. Helen Rajpar, Stuart H Ralston, Fernando Rivadeneira, Bruce G Robinson, Merry ZC Ruan, Steven J. Scheinman, Scott J. Schurman, Yiping Shen, Eileen M. Shore, Caroline Silve, Natalie A. Sims, Anil Singh, Allen M. Spiegel, Rajesh V. Thakker, André G. Uitterlinden, Ana M. Valdes, Wim Van Hul, Lee S. Weinstein, Michael P. Whyte, Lianping Xing, Tie-Lin Yang, Michael J. Zuscik
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de4f2f36f1ae9aca4e4d992969e23176
https://doi.org/10.1016/b978-0-12-387829-8.00041-x
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9
An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia
Autor: Raymond P. Boot-Handford, M. Helen Rajpar, Christopher Clowes, Michael D. Briggs, David J. Thornton, Peter A. Bell, Leo A. H. Zeeff, Seema Nundlall, Benjamin Gardner
Publikováno v: Cell Stress & Chaperones
Multiple epiphyseal dysplasia (MED) can result from mutations in matrilin-3, a structural protein of the cartilage extracellular matrix. We have previously shown that in a mouse model of MED the tibia growth plates were normal at birth but developed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368c98f42ddc8b696ecf62b7e89ec736
https://pubmed.ncbi.nlm.nih.gov/20428984
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10
Targeted induction of endoplasmic reticulum stress induces cartilage pathology
Autor: Rachel Eardley, Louise H. W. Kung, Richard Poulsom, Mel Heeran, Lynnette Knowles, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford, M. Helen Rajpar, Ben T. McDermott, Peter Arvan, Richard Wilson, Karl E. Kadler, David J. Thornton
Publikováno v: Rajpar, M H, McDermott, B, Kung, L, Eardley, R, Knowles, L, Heeran, M, Thornton, D J, Wilson, R, Bateman, J F, Poulsom, R, Arvan, P, Kadler, K E, Briggs, M D & Boot-Handford, R P 2009, ' Targeted induction of endoplasmic reticulum stress induces cartilage pathology ', PL o S Genetics, vol. 5, no. 10, e1000691 . https://doi.org/10.1371/journal.pgen.1000691
PLoS Genetics
PLoS Genetics, Vol 5, Iss 10, p e1000691 (2009)
Pathologies caused by mutations in extracellular matrix proteins are generally considered to result from the synthesis of extracellular matrices that are defective. Mutations in type X collagen cause metaphyseal chondrodysplasia type Schmid (MCDS), a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6820740417420de975724f13aaac4d58
https://doi.org/10.1371/journal.pgen.1000691
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