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Akademický článek

The Economic Consequences of Sirolimus Treatment in Patients With Vascular Malformations

Autor: Veroniek E. M. Harbers, Wietske Kievit, Raquel Duque Jimenez, Leo J. Schultze Kool, Ingrid M. P. van Rijnsoever, Bas H. Verhoeven, Carine J. M. van der Vleuten, D. Maroeska W. M. te Loo, Members of the Vascular Anomalies Working Group (VASCA WG) of the European Reference Network for Rare Multisystemic Vascular Diseases (VASCERN)—Project ID:

Publikováno v: Journal of Vascular Anomalies, Vol 5, Iss 2, p e092 (2024)

Objectives:. Sirolimus is one of the first oral drugs for safe and effective treatment of patients with vascular malformations, and may save (expensive) interventions. Therefore the objective was to investigate the cost-effectiveness of sirolimus in

Externí odkaz: https://doaj.org/article/c89fe75e4ce34841b0ee0319cd1cd153

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Akademický článek

Clinical differences in sirolimus treatment with low target levels between children and adults with vascular malformations – A nationwide trial

Autor: Veroniek E. M. Harbers, Lilly G. J. M. Zwerink, Gerard A. Rongen, Willemijn M. Klein, Carine J. M. van derVleuten, Ingrid M. P. vanRijnsoever, Lynda Gerdsen‐Drury, Uta E. Flucke, Bas H. Verhoeven, Peter C. J. deLaat, Chantal M. A. M. van derHorst, Leo J. Schultze Kool, D. Maroeska W. M. teLoo

Publikováno v: Clinical and Translational Science, Vol 16, Iss 5, Pp 781-796 (2023)

Abstract The clinical presentation of patients with slow‐flow vascular malformations is very heterogeneous. High clinical burden and subsequent reduced health‐related quality of life is something they have in common. There is an unmet medical nee

Externí odkaz: https://doaj.org/article/a55fba27e7964f5a87dd8702783b6dfe

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Akademický článek

Magnitude and relevance of change in health-related quality of life in patients with vascular malformations treated with sirolimus

Autor: Veroniek E. M. Harbers, Frédérique C. M. Bouwman, Ingrid M. P. van Rijnsoever, Bas H. Verhoeven, Carine J. M. van der Vleuten, Leo J. Schultze Kool, Peter C. J. de Laat, Chantal M. A. M. van der Horst, Wietske Kievit, D. Maroeska W. M. te Loo

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

IntroductionVascular malformations are rare congenital anomalies of the vascular system, which can involve the capillaries, veins, arteries, lymphatics, or a combination of vessel types. Patients with vascular malformations experience an impaired hea

Externí odkaz: https://doaj.org/article/30adb709a8db488493df56d290cc0f8e

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Effective low-dose sirolimus regimen for kaposiform haemangioendothelioma with Kasabach-Merritt phenomenon in young infants

Autor: Veroniek E. M. Harbers, Nathalie van der Salm, Sjoert A. H. Pegge, Carine J. M. van der Vleuten, Bas H. Verhoeven, Sabine L. A. G. Vrancken, Leo J. Schultze Kool, Joris Fuijkschot, D. Maroeska M. W. M. te Loo

Publikováno v: British Journal of Clinical Pharmacology, 88, 2769-2781
British Journal of Clinical Pharmacology, 88(6), 2769-2781. Wiley
British Journal of Clinical Pharmacology, 88, 6, pp. 2769-2781

Contains fulltext : 251797.pdf (Publisher’s version ) (Open Access) AIMS: Management of kaposiform haemangioendotheliomas (KHE) with Kasabach-Merritt phenomenon is challenging in young infants who are subjected to developmental pharmacokinetic chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819e3e3a6b6bfbd77df81f4dd94d744e
https://doi.org/10.1111/bcp.15202

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Fast Pyrolysis of Pine Wood Pretreated by Large Pilot-Scale Thermomechanical Refining for Biochemical Production

Autor: Ian D. Suckling, Thije J. M. Harbers, Ferran de Miguel Mercader, Kirk M. Torr, Daniel J. van de Pas, Karl D. Murton, Martin Cooke-Willis

Publikováno v: Industrial & Engineering Chemistry Research. 59:21294-21304

Pretreatments of lignocellulosic biomass prior to fast pyrolysis need to give a better yield and quality of pyrolysis oil and be practical to implement at a commercial scale. This study demonstrate...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99403b69a15c5c7de536ad11f2641f99
https://doi.org/10.1021/acs.iecr.0c04734

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Patients with Congenital Low-Flow Vascular Malformation Treated with Low Dose Sirolimus

Autor: D. Maroeska W.M. te Loo, Willemijn M. Klein, Gerard A. Rongen, Veroniek E M Harbers, Chantal M.A.M. van der Horst, Bas H. Verhoeven, Leo J. Schultze Kool, Peter C. J. de Laat, Carine J.M. van der Vleuten

Publikováno v: Advances in Therapy, 38, 3465-3482
Advances in Therapy
Advances in Therapy, 38(6), 3465-3482. Springer International Publishing AG
Advances in therapy, 38(6), 3465-3482. Health Communications Inc.
Advances in Therapy, 38, 6, pp. 3465-3482

Introduction Patients with congenital vascular malformations often suffer from an impaired quality of life (QoL) because of pain and functional disabilities. Previous studies have shown that the mTOR inhibitor sirolimus can reduce complaints and impr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e22127afbb0a4d584ce98e3ccc7054
http://hdl.handle.net/2066/235319

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Pilot study in patients with congenital low-flow vascular malformation treated with low dose sirolimus

Autor: Gerard A. Rongen, Willemijn M. Klein, Bas H. Verhoeven, van der Carine Vleuten, de Peter Laat, Veroniek E M Harbers, van der Chantal Horst, te Maroeska Loo, Leo J. Schultze Kool

Background Patients with congenital low-flow vascular malformations (capillary (CM), lymphatic (LM), venous (VM) or combined) may have an impaired quality of life (QoL), due to their symptoms, which include pain, swelling, bleeding, thrombosis, and f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e7a7c4d38a913db5984c71f3d2cb6b0
https://doi.org/10.21203/rs.3.rs-132412/v1

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The Internet of Things in a Smart Society: How Government Policy Can Help Seize Opportunities and Mitigate Threats

Autor: J.J. van Berkel, M. Harbers, Bargh, R.L.D. Pool, S.W. van den Braak

Publikováno v: Public Administration and Information Technology ISBN: 9783030374631
Gil-Garcia J., Pardo T., Gasco-Hernandez M. (eds) Beyond Smart and Connected Governments. Public Administration and Information Technology, vol 30., 2020. Springer

The IoT is a revolutionary development for both society and governments. In this chapter opportunities and threats of the IoT are discussed. Linking technological, societal, economic, and policy-oriented aspects of the IoT, this chapter introduces a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1641653a1b59cd01d28698bbbcafd7bc
https://doi.org/10.1007/978-3-030-37464-8_2

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Crushing of dolutegravir fixed-dose combination tablets increases dolutegravir exposure

Autor: Angela Colbers, David M. Burger, Pauline D.J. Bollen, Veroniek E M Harbers, Marjolijn Duisenberg-van Essenberg, Marieke Roskam-Kwint

Publikováno v: Journal of Antimicrobial Chemotherapy, 73, 2430-2434
Journal of Antimicrobial Chemotherapy, 73, 9, pp. 2430-2434

Background If HIV patients are unconscious or cannot swallow tablets for other reasons, antiretroviral medication is crushed and dissolved prior to administration. Crushing can alter drug exposure, possibly leading to treatment failure, development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2cb2000d3c878593530c45ae4dce5b
https://doi.org/10.1093/jac/dky191

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Akademický článek

Games and Agents: Designing Intelligent Gameplay

Autor: F. Dignum, J. Westra, W. A. van Doesburg, M. Harbers

Publikováno v: International Journal of Computer Games Technology, Vol 2009 (2009)

There is an attention shift within the gaming industry toward more natural (long-term) behavior of nonplaying characters (NPCs). Multiagent system research offers a promising technology to implement cognitive intelligent NPCs. However, the technologi

Externí odkaz: https://doaj.org/article/c579eb270a6c469faf0dd309d4d1c2f2

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