Zobrazeno 1 - 10
of 111
pro vyhledávání: '"M Hansbro, P"'
Autor:
Rajan Thapa, Anjana Thapa Magar, Jesus Shrestha, Nisha Panth, Sobia Idrees, Tayyaba Sadaf, Saroj Bashyal, Bassma H. Elwakil, Vrashabh V. Sugandhi, Satish Rojekar, Ram Nikhate, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Philip M Hansbro, Keshav Raj Paudel
Publikováno v:
MedComm, Vol 5, Iss 12, Pp n/a-n/a (2024)
Abstract Lung cancer (LC) continues to pose the highest mortality and exhibits a common prevalence among all types of cancer. The genetic interaction between human eukaryotes and microbial cells plays a vital role in orchestrating every physiological
Externí odkaz:
https://doaj.org/article/6dc4f5ec4c99473284f9f3dbdda6059d
Autor:
Gabriela Martins Costa Gomes, Carla Rebeca Da Silva Sena, Vanessa E Murphy, Philip M Hansbro, Malcolm R Starkey, Peter G Gibson, Joerg Mattes, Adam M Collison
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 9, Pp n/a-n/a (2024)
Abstract Objectives Bronchiolitis is a leading cause of infant hospitalisation in the first year of life, and it preferentially affects infants born to mothers with asthma. Here, we evaluate cord blood granulocytes in infants born to mothers with ast
Externí odkaz:
https://doaj.org/article/5bb2885998e54de78808aca80d092734
Autor:
Jemma R Mayall, Jay C Horvat, Niamh E Mangan, Anne Chevalier, Huw McCarthy, Daniel Hampsey, Chantal Donovan, Alexandra C Brown, Antony Y Matthews, Nicole A de Weerd, Eveline D de Geus, Malcolm R Starkey, Richard Y Kim, Katie Daly, Bridie J Goggins, Simon Keely, Steven Maltby, Rennay Baldwin, Paul S Foster, Michael J Boyle, Pradeep S Tanwar, Nicholas D Huntington, Paul J Hertzog, Philip M Hansbro
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 2, Pp 267-293 (2024)
Abstract The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in the uterus during infection is critical, yet no studi
Externí odkaz:
https://doaj.org/article/27c077dad3a5489b8adb434699dbf324
Autor:
Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immune cells in all infla
Externí odkaz:
https://doaj.org/article/60288ffe24fd40148d0b5a1960f9d444
Autor:
Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that th
Externí odkaz:
https://doaj.org/article/c49c73a4f4614f95ae1cab28b0686048
Autor:
Luke A. Farrell, Matthew B. O’Rourke, Matthew P. Padula, Fernando Souza-Fonseca-Guimaraes, Gaetano Caramori, Peter A. B. Wark, Shymali C. Dharmage, Phillip M. Hansbro
Publikováno v:
Proteomes, Vol 12, Iss 3, p 23 (2024)
Chronic obstructive pulmonary disease (COPD) ranks as the third leading cause of global illness and mortality. It is commonly triggered by exposure to respiratory irritants like cigarette smoke or biofuel pollutants. This multifaceted condition manif
Externí odkaz:
https://doaj.org/article/9c4b3726855f4797953a27d30563b8e7
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 1113-1128 (2023)
The virus interacts with its hosts by developing protein-protein interactions. Most viruses employ protein interactions to imitate the host protein: A viral protein with the same amino acid sequence or structure as the host protein attaches to the ho
Externí odkaz:
https://doaj.org/article/889fbb57f3ae45ffb5868c98d851a0e7
Autor:
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-
Externí odkaz:
https://doaj.org/article/780fdb67fa074e35823aa88357231e9d
Autor:
Victoria Jessamine, Samir Mehndiratta, Gabriele De Rubis, Keshav Raj Paudel, Saritha Shetty, Divya Suares, Dinesh Kumar Chellappan, Brian G. Oliver, Phillip M. Hansbro, Kamal Dua
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25393- (2024)
Chronic Obstructive Pulmonary Disease (COPD) is a dilapidating condition which is characterized by inflammation, an excess in free radical generation and airway obstruction. Currently, the drugs commercially available for the management of COPD pose
Externí odkaz:
https://doaj.org/article/08780e1e9e4e40aca3248fb561f4f470
Autor:
Nikhil T. Awatade, Andrew T. Reid, Kristy S. Nichol, Kurtis F. Budden, Punnam Chander Veerati, Prabuddha S. Pathinayake, Christopher L. Grainge, Philip M. Hansbro, Peter A. B. Wark
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Primary air liquid interface (ALI) cultures of bronchial epithelial cells are used extensively to model airway responses. A recent advance is the development of conditional reprogramming that enhances proliferative capability. Several differ
Externí odkaz:
https://doaj.org/article/34e398b88c08484c9891f298e967ba74