Zobrazeno 1 - 10
of 118
pro vyhledávání: '"M H Thomas"'
Autor:
Nathan Blake, Riana Gaifulina, Lewis D. Griffin, Ian M. Bell, Manuel Rodriguez-Justo, Geraint M. H. Thomas
Publikováno v:
Cancers, Vol 15, Iss 6, p 1720 (2023)
Defective DNA mismatch repair is one pathogenic pathway to colorectal cancer. It is characterised by microsatellite instability which provides a molecular biomarker for its detection. Clinical guidelines for universal testing of this biomarker are no
Externí odkaz:
https://doaj.org/article/5252fa1a68da435a93cf696b20e4c524
Publikováno v:
Diagnostics, Vol 12, Iss 6, p 1491 (2022)
Raman Spectroscopy has long been anticipated to augment clinical decision making, such as classifying oncological samples. Unfortunately, the complexity of Raman data has thus far inhibited their routine use in clinical settings. Traditional machine
Externí odkaz:
https://doaj.org/article/b48a825ede1145acbdf3e0c989431a3c
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:553-559
Crystallographers have an array of search-model options for structure solution by molecular replacement (MR). The well established options of homologous experimental structures and regular secondary-structure elements or motifs are increasingly suppl
Autor:
Felix Simkovic, Jens M. H. Thomas, Ronan M. Keegan, Martyn D. Winn, Olga Mayans, Daniel J. Rigden
Publikováno v:
IUCrJ, Vol 3, Iss 4, Pp 259-270 (2016)
For many protein families, the deluge of new sequence information together with new statistical protocols now allow the accurate prediction of contacting residues from sequence information alone. This offers the possibility of more accurate ab initio
Externí odkaz:
https://doaj.org/article/3caa52adb6874381ad5968a460132805
Autor:
Jens M. H. Thomas, Ronan M. Keegan, Jaclyn Bibby, Martyn D. Winn, Olga Mayans, Daniel J. Rigden
Publikováno v:
IUCrJ, Vol 2, Iss 2, Pp 198-206 (2015)
Coiled-coil protein folds are among the most abundant in nature. These folds consist of long wound α-helices and are architecturally simple, but paradoxically their crystallographic structures are notoriously difficult to solve with molecular-replac
Externí odkaz:
https://doaj.org/article/96960e5de316451abc37a27e314fe139
Autor:
Eugene Krissinel, Andrey A. Lebedev, Ville Uski, Charles B. Ballard, Ronan M. Keegan, Oleg Kovalevskiy, Robert A. Nicholls, Navraj S. Pannu, Pavol Skubák, John Berrisford, Maria Fando, Bernhard Lohkamp, Marcin Wojdyr, Adam J. Simpkin, Jens M. H. Thomas, Christopher Oliver, Clemens Vonrhein, Grzegorz Chojnowski, Arnaud Basle, Andrew Purkiss, Michail N. Isupov, Stuart McNicholas, Edward Lowe, Josep Triviño, Kevin Cowtan, Jon Agirre, Daniel J. Rigden, Isabel Uson, Victor Lamzin, Ivo Tews, Gerard Bricogne, Andrew G. W. Leslie, David G. Brown
Nowadays, progress in the determination of three-dimensional macromolecular structures from diffraction images is achieved partly at the cost of increasing data volumes. This is due to the deployment of modern high-speed, high-resolution detectors, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70211be538eb43722afb9f6169aea790
https://eprints.soton.ac.uk/471374/
https://eprints.soton.ac.uk/471374/
Autor:
Rob J Stanley, Geraint M H Thomas
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151861 (2016)
G proteins are an important family of signalling molecules controlled by guanine nucleotide exchange and GTPase activity in what is commonly called an 'activation/inactivation cycle'. The molecular mechanism by which guanine nucleotide exchange facto
Externí odkaz:
https://doaj.org/article/fab01f571b55415da88711610efc62b0
Publikováno v:
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
Thomas, J M H, Keegan, R M, Rigden, D J & Davies, O R 2020, ' Extending the scope of coiled-coil crystal structure solution by AMPLE through improved ab initio modelling ', Acta Crystallographica Section D: Structural Biology, pp. 272-284 . https://doi.org/10.1107/S2059798320000443
Acta Crystallographica. Section D, Structural Biology
Thomas, J M H, Keegan, R M, Rigden, D J & Davies, O R 2020, ' Extending the scope of coiled-coil crystal structure solution by AMPLE through improved ab initio modelling ', Acta Crystallographica Section D: Structural Biology, pp. 272-284 . https://doi.org/10.1107/S2059798320000443
Acta Crystallographica. Section D, Structural Biology
The solution of coiled-coil crystal structures may be achieved by AMPLE through the use of ensembled ab initio models in molecular replacement. Improvements in ab initio modelling of elongated helices and oligomeric coiled-coils allow AMPLE to solve
Autor:
Jens M. H. Thomas, Martin Savko, Charles Ballard, Daniel J. Rigden, William Shepard, Marcin Wojdyr, Ronan M. Keegan, Andrey Lebedev, Felix Simkovic, Adam J. Simpkin, Ville Uski
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
Improvements to the sensitivity of the search for suitable molecular-replacement search models in SIMBAD through the use of Phaser and an ensemble-based model database are reported.
The conventional approach to search-model identification in mol
The conventional approach to search-model identification in mol
Publikováno v:
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
Acta Crystallographica. Section D, Structural Biology
Acta Crystallographica. Section D, Structural Biology
Predicted ab initio protein models from online databases are a useful supplement to the PDB for molecular replacement, but usually require nontrivial processing to succeed.
Molecular replacement (MR) is the predominant route to solution of the p
Molecular replacement (MR) is the predominant route to solution of the p