Výsledky vyhledávání - "M H Silverman"

Safety, Tolerability and Pharmacokinetics of Icapamespib, a Selective Epichaperome Inhibitor, in Healthy Adults

Autor: M H, Silverman, S, Duggan, G, Bardelli, B, Sadler, C, Key, M, Medlock, L, Reynolds, B, Wallner

Publikováno v: The Journal Of Prevention of Alzheimer's Disease.

Neurodegenerative diseases are devastating conditions that most commonly affect individuals 65 years and older. Currently there are no effective treatments or cures for neurodegenerative diseases, and therapeutics that selectively target the underlyi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68627fb209ffd8444e0da15cd2c685b3
https://doi.org/10.14283/jpad.2022.71

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Tolerability, pharmacokinetics and concentration-dependent hemodynamic effects of oral CF101, an A3 adenosine receptor agonist, in healthy young men

Autor: P Fishman, A R van Troostenburg, W D H Carey, W D Kerns, I Cohn, E V Clark, K L L Fong, S. Bar-Yehuda, Steven J. Warrington, M H Silverman

Publikováno v: Int. Journal of Clinical Pharmacology and Therapeutics. 42:534-542

Objectives: To assess safety, tolerability, pharmacokinetics and hemodynamic effects of oral CF 101, an A3 adenosine receptor (A3AR) agonist, in healthy men. Methods: One single and 1 repeated dose, parallel-group, ascending dose, double-blind and pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78e6556be75c9c2c5cf4a6989c561b6
https://doi.org/10.5414/cpp42534

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Safety, tolerability and pharmacokinetics of subcutaneous Å6, an 8-amino acid peptide with anti-angiogenic properties, in healthy men

Autor: T R Jones, Steven J. Warrington, G.N. Lam, M H Silverman, J A Dyck-Jones, A R van Troostenburg, D Lee

Publikováno v: Int. Journal of Clinical Pharmacology and Therapeutics. 42:253-259

Aims: To assess the safety, tolerability and pharmacokinetics of subcutaneous A6, an 8-amino acid peptide with anti-angiogenic properties, in healthy men. Methods: Double-blind, placebo-controlled, parallel-group, dose-rising, phase I study of single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6925041d996d4a0a8c6f8b947d0b026c
https://doi.org/10.5414/cpp42253

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Multiple-dose pharmacokinetics and safety of oral amifloxacin in healthy volunteers

Autor: J A Cook, Richard R. Brown, J J Schentag, David E. Nix, M H Silverman, D J Schelling, R M Stroshane

Publikováno v: Antimicrobial Agents and Chemotherapy. 34:974-979

The multiple-dose pharmacokinetics and safety of amifloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy male volunteers. Amifloxacin was administered orally at 200, 400, or 600 mg every 12 h (q12h) and 400, 600, or 800 mg e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab3f5d2f94c6d5a1ccbd141a66b720a
https://doi.org/10.1128/aac.34.6.974

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Preliminary study of the pharmacokinetics of oral amifloxacin in elderly subjects

Autor: J A Cook, Richard R. Brown, M H Silverman, A W Boddy, R M Stroshane, R Sauerschell

Publikováno v: Antimicrobial Agents and Chemotherapy. 34:751-754

Amifloxacin pharmacokinetics after a single oral dose in healthy elderly subjects were determined. Five males and five females aged 65 to 79 years and having creatinine clearances of 39.3 to 87.2 ml/h per kg of body weight were given a 200-mg amiflox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71243e022ddc0eea307b6bbf8e22e88e
https://doi.org/10.1128/aac.34.5.751

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Randomized, controlled trial of a 10-day course of amifloxacin versus trimethoprim-sulfamethoxazole in the treatment of acute, uncomplicated urinary tract infection. Amifloxacin Multi-Center Trial Group

Autor: M H Silverman, A Iravani, D J Schelling, E J Boyko, R A Wright

Publikováno v: ResearcherID

We conducted a randomized controlled trial of orally administered amifloxacin versus trimethoprimsulfamethoxazole (TMP-SMX) as treatments of acute uncomplicated urinary tract infection in women. Amifloxacin at a dosage of 200 mg twice a day appeared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5167558b26cf882dfb0cd471d6d669d3
https://doi.org/10.1128/aac.34.4.665

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A phase II, multi-center study of a new non-cytotoxic A3 adenosine receptor agonist CF101, dose-finding (randomized blinded) in patients (pts)with refractory metastatic colorectal cancer

Autor: S. M. Stemmer, A. Shani, B. Klein, M. H. Silverman, I. Lorber, M. Farbstein, E. Shmueli, A. Figer

Publikováno v: Journal of Clinical Oncology. 22:3153-3153

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f23b3635c9b10bbb04d2e56b53228c6
https://doi.org/10.1200/jco.2004.22.90140.3153

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Polyarteritis nodosa associated with ulcerative colitis

Autor: M H, Silverman

Publikováno v: The Journal of rheumatology. 11(3)

Three months after colectomy for severe ulcerative colitis, an 18-year-old male presented with a multisystem illness characterized by fever, arthralgias, hypertension, and declining renal function. A diagnosis of polyarteritis nodosa was made histolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74215197efc50e897be2a0894df17580
https://pubmed.ncbi.nlm.nih.gov/6145799

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