Zobrazeno 1 - 10
of 22
pro vyhledávání: '"M H Schneiderman"'
Publikováno v:
Radiation research. 149(2)
Minimal residual disease in lymphoma patients is a major problem in the clinical management of their cancer. High-dose chemotherapy followed by autologous bone marrow transplantation has been used to treat the disease. However, residual lymphoma may
Publikováno v:
Journal of virology. 70(9)
The majority of human cancers appear to arise from mutations caused by DNA damage (5). One significant source of mutations is error-prone repair of DNA double-strand breaks (DSB). DSB can result from normal oxidative metabolism, replication errors, a
Autor:
K A, Harrison, G V, Dalrymple, J, Baranowska-Kortylewicz, K P, Holdeman, M H, Schneiderman, R P, Lieberman, J G, Sharp, S M, Cohen, P K, Leichner, S C, Augustine, M A, Tempero, R J, Taylor, R K, Chiou
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 37
The emphasis of radiolabeled iododeoxyuridine (*IUdR) research at our institution to date has been to assess its safety as a potential therapeutic agent. Toward this goal, we have performed preclinical and clinical studies, using various routes of ad
Autor:
M H, Schneiderman, G S, Schneiderman
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 37
Studies were undertaken to determine the relationship between IUdR concentration and the duration of radiolabeled IUdR treatment required to incorporate the equivalent of a D(o) dose in vitro and to estimate the treatment parameters necessary to inco
Publikováno v:
Radiation research. 145(1)
Cell progression into mitosis and chromatid aberration frequencies were compared in two Chinese hamster ovary (CHO) cell lines after incorporation of 125IdUrd. Asynchronous, exponentially growing populations of CHO K1 and the DNA repair-deficient, ra
Publikováno v:
Cancer research. 53(24)
Annexin II is a substrate for oncogene and growth factor-associated protein-tyrosine kinases. Elevated expression of annexin II is seen in different types of cancers and recent evidence indicates a role for annexin II in DNA synthesis and cell prolif
Publikováno v:
Radiation research. 130(1)
Chinese hamster ovary cells were synchronized at the G1/S-phase boundary of the cell cycle and pulse-labeled for 10 min with 125I-iododeoxyuridine 30 min after entering the S phase. Cell samples were harvested for freezing and 125I-decay accumulation
Publikováno v:
Radiation research. 122(3)
The precise cell cycle time of association between labeled DNA (the radiation source) and the non-DNA cell structure whose damage is responsible for radiation-induced division delay was measured. Mitotic cells were selected from a monolayer of Chines
Autor:
M. H. Schneiderman, Dexter M. Easton
Publikováno v:
Cell and tissue kinetics. 20(4)
A mathematical model is presented that predicts the delay of mitosis caused by X-irradiation of an asynchronous, exponentially growing cell culture (data of Schneiderman & Schneiderman, 1984). In the model, based on Gompertz kinetics, the driving fun
Autor:
M H, Schneiderman, G S, Schneiderman
Publikováno v:
Radiation research. 98(2)
The progression of Chinese hamster ovary (CHO) G2 cells into mitosis and their survival was measured after X-ray doses up to 4.0 Gy. S-phase cells were prevented from reaching mitosis by labeling with 125IUdR for 10 min prior to irradiation of the ex