Zobrazeno 1 - 10
of 25
pro vyhledávání: '"M H Perdue"'
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 60:16-25
Over the past 15 years, it has become very clear that the immune system can have profound effects on epithelial function. Acute immune-mediated changes in epithelial physiology are beneficial to host defense against enteric pathogens. For example, io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04174e178e964c8fe3ce7d9d172904c2
https://doi.org/10.4269/ajtmh.1999.60.16
https://doi.org/10.4269/ajtmh.1999.60.16
Autor:
L C, Yu, M H, Perdue
Publikováno v:
Immunological reviews. 179
A single layer of epithelial cells lines the gastrointestinal tract, forming a critical barrier between the lunminal contents, which includes antigens and other noxious substances, and the body proper. It has become clear in recent years that the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff5f422ec4d33f9f6e6673db2caa8362
https://pubmed.ncbi.nlm.nih.gov/11292029
https://pubmed.ncbi.nlm.nih.gov/11292029
Publikováno v:
The American journal of pathology. 158(3)
Intestinal immune cells are less reactive than those in the peripheral blood; however, such cells from patients with Crohn's disease may be more responsive to bacterial products. Our study examined if nonpathogenic bacteria or lipopolysaccharide (LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3172330b225556adc062967de27e6f3e
https://pubmed.ncbi.nlm.nih.gov/11238058
https://pubmed.ncbi.nlm.nih.gov/11238058
Autor:
J D, Söderholm, M H, Perdue
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 280(1)
The influence of stress on the clinical course of a number of intestinal diseases is increasingly being recognized, but the underlying mechanisms are largely unknown. This themes article focuses on recent findings related to the effects of stress on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05bef11603ca650d9a1d6a4eb179ab68
https://pubmed.ncbi.nlm.nih.gov/11123192
https://pubmed.ncbi.nlm.nih.gov/11123192
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(5)
Ag challenge to the apical surface of tracheal epithelium results in a rapid ion secretory response due to the activation of mast cells. The aim of this study was to examine the impact of sensitization and specific Ag challenge on the timing, route,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0de03205f71e3e6bf2d9c803208ddf37
https://pubmed.ncbi.nlm.nih.gov/10453020
https://pubmed.ncbi.nlm.nih.gov/10453020
Autor:
M H, Perdue
Publikováno v:
The American journal of physiology. 277(1)
We have known for many years that mucosal responses to antigens are regulated by immune cells and their molecular signals. More recently, it has become clear that epithelial cells also synthesize and secrete chemokines and cytokines. A sophisticated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97746c2342eb7f05bcabb9570ae30299
https://pubmed.ncbi.nlm.nih.gov/10409144
https://pubmed.ncbi.nlm.nih.gov/10409144
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(3)
Glucocorticosteroids are a mainstay therapy in inflammatory bowel disease and other chronic inflammatory conditions. However, severe systemic side effects are associated with their long-term use. The new generation of glucocorticosteroids have a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65a6a6764234196100ad220807e48907
https://pubmed.ncbi.nlm.nih.gov/10336512
https://pubmed.ncbi.nlm.nih.gov/10336512
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(5)
Luminal Ag challenge of intestinal segments from sensitized rats results in a rapid (approximately 3 min) secretory response. We previously showed in horseradish peroxidase (HRP)-sensitized rats that the initial phase of transepithelial Ag transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ce454e6d99a7ffe6552835fa8611c8e
https://pubmed.ncbi.nlm.nih.gov/9725256
https://pubmed.ncbi.nlm.nih.gov/9725256
Autor:
H, Anisman, M G, Baines, I, Berczi, C N, Bernstein, M G, Blennerhassett, R M, Gorczynski, A H, Greenberg, F T, Kisil, R D, Mathison, E, Nagy, D M, Nance, M H, Perdue, D K, Pomerantz, E R, Sabbadini, A, Stanisz, R J, Warrington
Publikováno v:
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 155(7)
A novel scientific discipline that examines the complex interdependence of the neural, endocrine and immune systems in health and disease has emerged in recent years. In health, the neuroimmunoregulatory network is fundamental to host defence and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88e0d00015d569accd036f7a4308495b
https://pubmed.ncbi.nlm.nih.gov/8837533
https://pubmed.ncbi.nlm.nih.gov/8837533
Budesonide inhibits T cell-initiated epithelial pathophysiology in an in vitro model of inflammation
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(1)
Recognition of the therapeutic value of glucocorticosteroids in the treatment of inflammation has preceded awareness of the mechanism(s) of action of these drugs. We recently showed that coculture of human T84 epithelial monolayers for 2 days with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d35e4559fe5dcec513412225588a9967
https://pubmed.ncbi.nlm.nih.gov/8613948
https://pubmed.ncbi.nlm.nih.gov/8613948