Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells

Autor: N. Osorio, L. Cathala, M. H. Meisler, M. Crest, J. Magistretti, P. Delmas

Publikováno v: The Journal of Physiology
The Journal of Physiology, Wiley, 2010, 588 (Pt 4), pp.651-70. ⟨10.1113/jphysiol.2010.183798⟩
The Journal of Physiology, 2010, 588 (Pt 4), pp.651-70. ⟨10.1113/jphysiol.2010.183798⟩

International audience; Cerebellar granule (CG) cells generate high-frequency action potentials that have been proposed to depend on the unique properties of their voltage-gated ion channels. To address the in vivo function of Nav1.6 channels in deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7bd51c7041ff55c1abe17f02ed5ef2
https://hal.archives-ouvertes.fr/hal-00625098

Mouse chromosome 3

Autor: M H, Meisler, M F, Seldin

Publikováno v: Mammalian Genome. 1:S42-S50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016989e703ed4721dea57f516f1cc7f7
https://doi.org/10.1007/bf00656485

The spastic paraplegia SPG10 locus: narrowing of critical region and exclusion of sodium channel gene SCN8A as a candidate

Autor: A Escayg, Evan Reid, A M Dearlove, David C. Rubinsztein, D D Lee, M H Meisler

Publikováno v: Journal of medical genetics. 38(1)

Editor—The hereditary spastic paraplegias (HSPs) are clinically characterised by progressive lower limb spasticity. The spasticity may occur in isolation (“pure”) or may be complicated by other major clinical features. Autosomal dominant, autos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f0eec42ace3ef2a9cfec3d74fffbd5
https://pubmed.ncbi.nlm.nih.gov/11334010

Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13

Autor: W, Jang, A, Hua, S V, Spilson, W, Miller, B A, Roe, M H, Meisler

Publikováno v: Genome research. 9(1)

The mnd2 mutation on mouse chromosome 6 produces a progressive neuromuscular disorder. To determine the gene content of the 400-kb mnd2 nonrecombinant region, we sequenced 108 kb of mouse genomic DNA and 92 kb of human genomic sequence from the corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::478925a6417a9555107974b9aaa95471
https://pubmed.ncbi.nlm.nih.gov/9927484

Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron

Autor: D C, Kohrman, J B, Harris, M H, Meisler

Publikováno v: The Journal of biological chemistry. 271(29)

Analysis of a transgene-induced mutation at the mouse med locus led to the identification of the novel voltage-gated sodium channel gene Scn8a (Burgess, D. L., Kohrman, D. C., Galt, J., Plummer, N. W., Jones, J. M., Spear, B., and Meisler, M. H.(1995

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::444f99763fa315837c36d75f6e815059
https://pubmed.ncbi.nlm.nih.gov/8663325