Zobrazeno 1 - 10
of 28
pro vyhledávání: '"M H Duncan"'
Autor:
David W. Cescon, Wail Ba-alawi, Tak W. Mak, Jennifer Silvester, M. J. Elliott, Zhaleh Safikhani, M. H. Duncan, Benjamin Haibe-Kains, Kelsie L. Thu, Antonia Concetta Elia, Arvind Singh Mer, Petr Smirnov
Publikováno v:
Proceedings of the National Academy of Sciences. 115
TTK protein kinase (TTK), also known as Monopolar spindle 1 (MPS1), is a key regulator of the spindle assembly checkpoint (SAC), which functions to maintain genomic integrity. TTK has emerged as a promising therapeutic target in human cancers, includ
Autor:
B E Favara, L Busque, Kenneth L. McClain, M H Duncan, Cheryl L. Willman, B B Griffith, D G Gilliland
Publikováno v:
New England Journal of Medicine. 331:154-160
Background The lesions of Langerhans'-cell histiocytosis (histiocytosis X), a proliferative histiocytic disorder of unknown cause, contain histiocytes similar in phenotype to dendritic Langerhans' cells. The disease ranges in severity from a fatal le
Publikováno v:
Pharmacotherapy. 17(5)
We evaluated the analgesic efficacy of EMLA cream after repeated bone marrow aspirations or lumbar punctures (LPs) in children with cancer, and compared the ratings among patients, their parents, physicians, and nurses. Data from LPs were analyzed at
Autor:
L, Pearson, C P, Leith, M H, Duncan, I M, Chen, T, McConnell, K, Trinkaus, K, Foucar, C L, Willman
Publikováno v:
Leukemia. 10(8)
Resistance to chemotherapy is a major problem in acute myeloid leukemia (AML). An important resistance mechanism in adult AML is active drug efflux mediated by the multidrug resistance protein-1 (MDR1). To determine if MDR1 is important in childhood
Autor:
M H, Duncan
Publikováno v:
Clinical chemistry. 41(8 Pt 1)
Publikováno v:
Clinics in laboratory medicine. 13(4)
This article discusses the evaluation of a patient for possible neutropenia. An evaluation must include an integration of complex factors such as age- and race-related normal ranges for absolute neutrophil count, an assessment of other hematopoietic
Publikováno v:
Cancer. 72(6)
Although flow cytometry (FCM) has become a widely used technique for the measurement of DNA content in solid tumors, the correlation of ploidy analysis by FCM with cytogenetic analysis (CGA) is not well described. The sensitivities of G-banded CGA an
Autor:
M H Duncan
Publikováno v:
BMJ (Clinical research ed.). 306(6870)
OBJECTIVE--To determine the feasibility of establishing a system of screening for neuroblastoma. DESIGN--Prospective study of mass screening in four clearly defined geographical areas. SETTING--Four health districts of the Northern region of England.
Autor:
V V, Joshi, A B, Cantor, G, Altshuler, E W, Larkin, J S, Neill, J J, Shuster, C T, Holbrook, F A, Hayes, R, Nitschke, M H, Duncan
Publikováno v:
Cancer. 69(8)
Histologic sections (minimum of four sections per patient) from 211 patients with neuroblastoma were reviewed. The tumors were resected before therapy, which was standardized according to age and stage. Low mitotic rate (MR) (less than or equal to te
Publikováno v:
Cancer genetics and cytogenetics. 53(2)
The biologic significance of clonal karyotypic abnormalities in human neoplasms is becoming better understood, but the significance of rare chromosomal aberrations is uncertain. Useful, yet arbitrary, cytogenetic definitions of a clone have been esta