Výsledky vyhledávání - "M H, el Kouni"

Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: relevance to chemotherapy

Autor: Osama M. Ashour, Fardos N. M. Naguib, O. N. Al Safarjalani, M. H. El Kouni, Naganna M. Goudgaon, Raymond F. Schinazi

Publikováno v: Cancer Chemotherapy and Pharmacology. 45:351-361

Purpose: The purpose of this investigation was to evaluate the efficacy of oral 5-(phenylselenenyl)-acyclouridine (PSAU) in increasing endogenous plasma uridine concentration as well as its ability to improve the bioavailability of oral uridine. PSAU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7181aecdc17288098cc9a9db88ea34b
https://doi.org/10.1007/s002800051002

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5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-o-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration

Autor: Fardos N. M. Naguib, Osama M. Ashour, M. H. El Kouni

Publikováno v: Biochemical Pharmacology. 51:1601-1611

5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA), the most potent inhibitor known of uridine phosphorylase (UrdPase, EC 2.4.2.3), the enzyme responsible for uridine catabolism, and 2',3',5'-tri-O-acetyluridine (TAU), a prodrug of uridine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::397354cf00d1c1cce76002ba8b589f75
https://doi.org/10.1016/0006-2952(96)00102-5

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Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii

Autor: M. H. El Kouni, Fardos N. M. Naguib, M. M. El Kouni, Max H. Iltzsch, Raymond P. Panzica

Publikováno v: Biochemical Pharmacology. 50:1685-1693

Preliminary characterization of Toxoplasma gondii phosphoribosyltransferase activity towards purine nucleobases indicates that there are at least two enzymes present in these parasites. One enzyme uses hypoxanthine, guanine, and xanthine as substrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e3077697cc5cbdf0b40079459497a8
https://doi.org/10.1016/0006-2952(95)02070-5

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Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy

Autor: M. H. El Kouni, Harold M. McClure, Jean Pierre Sommadossi, Daniel C. Anderson, Lauren Kidd, Erika M. Cretton

Publikováno v: Cancer Chemotherapy and Pharmacology. 37:14-22

The effects of subcutaneous administration of 5-benzylacyclouridine (BAU), a uridine phosphorylase (UrdPase, EC 2.4.2.3) inhibitor, on uridine concentration in plasma and urine were evaluated in rhesus monkeys. Administration of BAU at 50, 100 and 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839ff1d69de3341575ad858c4eab3909
https://doi.org/10.1007/bf00685624

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O5′,6-Methanocytidine — Synthesis, Conformational Properties and Deamination by Cytidine Deaminase

Autor: Sreenivasulu Megati, Steven E. Ealick, Fardos N. M. Naguib, M. H. el Kouni, Brian A. Otter, Robyn S. Klein

Publikováno v: Nucleosides and Nucleotides. 13:2151-2168

The synthesis of O5′,6-methanocytidine (4), a pyrimidine nucleoside restricted to the anti conformation, is described. Molecular modeling studies suggest that 4 is more flexible than conventional cyclonucleosides because of its larger-than-usual br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80be248761c6ecefab3781fa2318f0bb
https://doi.org/10.1080/15257779408013214

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ChemInform Abstract: Phenylselenenyl- and Phenylthio-Substituted Pyrimidines as Inhibitors of Dihydrouracil Dehydrogenase and Uridine Phosphorylase

Autor: Naganna M. Goudgaon, F. N. M. Naguib, M. H. El Kouni, Raymond F. Schinazi

Publikováno v: ChemInform. 25

Lithiation of 5-bromo-2,4-bis(benzyloxy)pyrimidine (3) with n-BuLi at -80 degrees C followed by the addition of diphenyl diselenide or diphenyl disulfide as an electrophile furnished the corresponding 5-(phenylhetera)-2,4-bis(benzyloxy)pyrimidine, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b9b54f18b3476832f04fcb3648e4cbf
https://doi.org/10.1002/chin.199426195

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Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication

Autor: Abdesslem Faraj, David Egron, Christian Périgaud, Gilles Gosselin, Martin L. Bryant, Erika Cretton-Scott, L.T. Martin, Laurent Placidi, Jean Louis Imbach, Anna Giulia Loi, M. H. El Kouni, J.-P. Sommadossi, Claire Pierra, Raymond F. Schinazi

Publikováno v: Antiviral chemistrychemotherapy. 12(2)

The β-L-nucleoside analogue β-L-2′,3′-dideoxy adenosine (β-L-ddA) has been shown to exhibit limited antiviral activities. This was attributed to its rapid catabolism through cleavage of the glycosidic bond and poor phosphorylation to the nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4122d2e5c599cf5a7c502d81d64e42e
https://pubmed.ncbi.nlm.nih.gov/11527047

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5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration. Implications for chemotherapy

Autor: O M, Ashour, F N, Naguib, M H, el Kouni

Publikováno v: Biochemical pharmacology. 51(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d168f88096372284280356db7877568
https://pubmed.ncbi.nlm.nih.gov/8687475

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Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside

Autor: O M, Ashour, F N, Naguib, M M, Khalifa, M H, Abdel-Raheem, R P, Panzica, M H, el Kouni

Publikováno v: Cancer research. 55(5)

5-(Benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA) was recently synthesized as a potent and specific inhibitor of uridine phosphorylase (EC 2.4.2.3), the enzyme responsible for the catabolism of 5-fluoro-2'-deoxyuridine (FdUrd) in many types

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61ff5c18d0c9e9032b845ee1a64481d5
https://pubmed.ncbi.nlm.nih.gov/7866994

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