Zobrazeno 1 - 10
of 34
pro vyhledávání: '"M H, de Groot"'
Publikováno v:
Tijdschrift voor psychiatrie. 60(9)
Specific and systematic data on health care providers' behaviour is needed to futher improve the care provided to suicidal patiënts in mental health care facilities.br/METHOD: Explorative observational study of all suicidal incidents (n=50) that occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27a814d8553156450ab1a9f1b5dd85cf
https://pubmed.ncbi.nlm.nih.gov/30215446
https://pubmed.ncbi.nlm.nih.gov/30215446
Autor:
C. Marco Timmers, Tijl Huijbregts, Ronald Christiaan Elgersma, Franciscus M. H. de Groot, GF Verheijden, Ruud Coumans, Patrick Henry Beusker, Jacques M. Lemmens, David F. Egging, Diels van den Dobbelsteen, Miranda M.C. van der Lee, Ruud Ubink, Wim H. A. Dokter, Wiro Michaël Petrus Bernardus Menge, Henri Johannes Spijker, John Joosten
Publikováno v:
Molecular Pharmaceutics. 12:1813-1835
Antibody-drug conjugates (ADCs) that are currently on the market or in clinical trials are predominantly based on two drug classes: auristatins and maytansinoids. Both are tubulin binders and block the cell in its progression through mitosis. We set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d112fc7f8b9f7d0584c7c81aa6b00e7
https://doi.org/10.1021/mp500781a
https://doi.org/10.1021/mp500781a
Publikováno v:
Tijdschrift voor psychiatrie. 59(3)
The outreach emergency psychiatric service plays an important role in recognising, arranging interventions and preventing suicide and suicidal behaviour. However, little is known about the assessments that members of the emergency team make when face
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f4560648854bf70f3d76369e75f31ec
https://pubmed.ncbi.nlm.nih.gov/28350141
https://pubmed.ncbi.nlm.nih.gov/28350141
Publikováno v:
Tijdschrift voor psychiatrie. 58(5)
Multidisciplinary evaluation of suicide cases effectively decreases the suicide rate in mental health care. A new suicide prevention tool (KEHR) can be used in this connection. KEHR has been developed on the basis of the Dutch multidisciplinary pract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b99b59a134e416fee274e6509ae418f
https://pubmed.ncbi.nlm.nih.gov/27213634
https://pubmed.ncbi.nlm.nih.gov/27213634
Autor:
Franciscus M. H. de Groot, Ralph Koekkoek, Hans W. Scheeren, Patrick Henry Beusker, Carsten Albrecht
Publikováno v:
Angewandte Chemie International Edition. 42:4490-4494
However, in all the branched structures or dendrimersreported so far, each singledrughastobeindependentlycleavedtobereleased.Here,we report dendrimers thathavebeenbuilttocompletelyand rapidly dissociate intoseparate building blocksupon a single trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f16cd3f8018e406d143b09e1d0f7d1
https://doi.org/10.1002/anie.200351942
https://doi.org/10.1002/anie.200351942
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2371-2376
The first prodrugs of camptothecin and 9-aminocamptothecin that are activated by the tumour-associated protease plasmin are reported. The tripartate prodrugs consist of a tripeptide sequence recognised by plasmin, which is linked to the 20-hydroxyl g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04678bd27295735381902f1ab6fd3c15
https://doi.org/10.1016/s0960-894x(02)00388-8
https://doi.org/10.1016/s0960-894x(02)00388-8
Publikováno v:
Current Medicinal Chemistry. 8:1093-1122
In order to improve current chemotherapeutic treatment and diminish severe side effects, several prodrug strategies have evolved to achieve site-specific delivery of cytotoxic anticancer agents. This review concentrates on recent developments of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc3d7ed52df3a9eeede54c3439621e3
https://doi.org/10.2174/0929867013372634
https://doi.org/10.2174/0929867013372634
Publikováno v:
Expert Opinion on Therapeutic Patents. 11:651-666
This paper highlights recent patents in the field of anthracycline prodrugs, which are employed in tumour-selective chemotherapy. The prodrugs can be a part of a two-step directed enzyme prodrug therapy (DEPT), which involves the localisation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47099e7a112fb3be23a5c01b5363f7b0
https://doi.org/10.1517/13543776.11.4.651
https://doi.org/10.1517/13543776.11.4.651
Publikováno v:
Biological Psychiatry. 40:1282-1287
Several decades of research have led to different hypotheses about cognitive functioning in depression; one of the hypotheses states that there is altered functioning of the hemispheres during a depressive episode. Lateralization studies have found d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d19703efd0dcd09eb2e68a47f9da7b
https://doi.org/10.1016/0006-3223(95)00654-0
https://doi.org/10.1016/0006-3223(95)00654-0