Výsledky vyhledávání - "M H, Van Regenmortel"

Antibodies from Patients with Rheumatoid Arthritis and Juvenile Chronic Arthritis Analyzed with Core Histone Synthetic Peptides

Autor: M. H. Van Regenmortel, Jean-Louis Pasquali, P. Bordigoni, S. Muller, N. Tuaillon, P. Youinou

Publikováno v: International Archives of Allergy and Immunology. 91:297-305

Antihistone antibodies were detected in the sera of a randomly selected group of patients with rheumatoid arthritis (RA) and juvenile chronic arthritis (JCA) by an enzyme-linked immunosorbent assay (ELISA) with the five individual histones and by imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3adf6ca38010d30e5ca5e04d50c04a9
https://doi.org/10.1159/000235131

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Differential recognition of epitopes present on monomeric and oligomeric forms of gp160 glycoprotein of human immunodeficiency virus type 1 by human monoclonal antibodies

Autor: G, Zeder-Lutz, J, Hoebeke, M H, Van Regenmortel

Publikováno v: European journal of biochemistry. 268(10)

The mechanism of infectivity neutralization of human immunodeficiency virus type 1 (HIV-1) by Ig is poorly understood. Three human monoclonal antibodies (mAbs 1b12, 2G12 and 2F5) that are able to neutralize primary isolates of HIV-1 in vitro have bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35a36c9433aafa176a210deba6e015b5
https://pubmed.ncbi.nlm.nih.gov/11358501

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Binding measurements as surrogate biological assays: surface plasmon resonance biosensors for characterizing vaccine components

Autor: M H, Van Regenmortel

Publikováno v: Developments in biologicals. 103

There is considerable interest in the possibility of using surrogate physico-chemical assays for the quality control of vaccine components. Since biological activity always depends on a first binding step, the primary criterion for assessing biologic

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https://pubmed.ncbi.nlm.nih.gov/11214255

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Are there two distinct research strategies for developing biologically active molecules: rational design and empirical selection?

Autor: M H, Van Regenmortel

Publikováno v: Journal of molecular recognition : JMR. 13(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d341e0e94ea31be082a1bf5a3342a5c6
https://pubmed.ncbi.nlm.nih.gov/10679890

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Biosensors and the search for structure-activity correlations

Autor: M H, Van Regenmortel

Publikováno v: Journal of molecular recognition : JMR. 12(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee6b02bebe02857f81c63b2d8d501137
https://pubmed.ncbi.nlm.nih.gov/10556874

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Molecular recognition in the post-reductionist era

Autor: M H, Van Regenmortel

Publikováno v: Journal of molecular recognition : JMR. 12(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::217e7a55b262ce5a58d98d8df0ef80dc
https://pubmed.ncbi.nlm.nih.gov/10398391

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Cross-reactivity of antibodies to retro-inverso peptidomimetics with the parent protein histone H3 and chromatin core particle. Specificity and kinetic rate-constant measurements

Autor: N, Benkirane, G, Guichard, M H, Van Regenmortel, J P, Briand, S, Muller

Publikováno v: The Journal of biological chemistry. 270(20)

A series of monoclonal antibodies has been generated against an hexapeptide of sequence IRGERA corresponding to the C-terminal residues 130-135 of histone H3 and three analogues of this model peptide. The analogues correspond to the D-enatiomer, cont

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https://pubmed.ncbi.nlm.nih.gov/7744843

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Transcending the structuralist paradigm in immunology-affinity and biological activity rather than purely structural considerations should guide the design of synthetic peptide epitopes

Autor: M H, Van Regenmortel

Publikováno v: Biomedical peptides, proteinsnucleic acids : structure, synthesisbiological activity. 1(3)

Synthetic peptides are frequently used to mimic the antigenic sites of proteins. In order to increase the level of mimicry between the peptide and the protein, it is important to understand the structural basis of protein antigenicity. A review of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32a7e09132468247e8f7b3ea86394779
https://pubmed.ncbi.nlm.nih.gov/9346841

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Predicting antigenic determinants in proteins: looking for unidimensional solutions to a three-dimensional problem?

Autor: M H, Van Regenmortel, J L, Pellequer

Publikováno v: Peptide research. 7(4)

In a recent review, Hopp (Peptide Research 6:183-190, 1993) claimed that the Hopp and Woods hydrophilicity method for locating antigenic determinants is superior to all other existing methods for predicting the B cell epitopes of proteins but that it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::297ed6d0cbe1cde4bce3e2f8d906e962
https://pubmed.ncbi.nlm.nih.gov/7535134

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