The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

Autor: Jens C. Brüning, Susanne Keipert, Bernd J. Pichler, Julia Zorn, Martin Klingenspor, Ines Pramme-Steinwachs, Siegfried Ussar, Martin Jastroch, Maria T. Diaz-Meco, Anna Fedl, Florian C. Maier, Markus Brielmeier, Jianfeng Huang, Stephan Sachs, Ahmed E. Othman, Henriette Uhlenhaut, Anna Fenzl, Jorge Moscat, M. H. Tschöp, Wolfgang M. Thaiss, Brian Finan, Maximilian Kleinert, Timo D. Müller, Kenneth A. Dyar, Manfred Kneilling, Stephen C. Woods, Angelika Scheideler, Dianxin Liu, Kerstin Stemmer, Christoffer Clemmensen, Katrin Fischer, Sheila Collins, André Gessner

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nat. Commun. 11:2306 (2020)
Nature Communications
Fischer, K, Fenzl, A, Liu, D, Dyar, K A, Kleinert, M, Brielmeier, M, Clemmensen, C, Fedl, A, Finan, B, Gessner, A, Jastroch, M, Huang, J, Keipert, S, Klingenspor, M, Brüning, J C, Kneilling, M, Maier, F C, Othman, A E, Pichler, B J, Pramme-Steinwachs, I, Sachs, S, Scheideler, A, Thaiss, W M, Uhlenhaut, H, Ussar, S, Woods, S C, Zorn, J, Stemmer, K, Collins, S, Diaz-Meco, M, Moscat, J, Tschöp, M H & Müller, T D 2020, ' The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation ', Nature Communications, vol. 11, no. 1, 2306 . https://doi.org/10.1038/s41467-020-16230-8

During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of Ucp1 and Pgc-1α. The mechanisms underlying ATF2 targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc1314eb5ff4321d5e23f918f17181f
http://link.springer.com/article/10.1038/s41467-020-16230-8

Are peptide conjugates the golden therapy against obesity?

Autor: Timo D. Müller, M. H. Tschöp, Maximilian Kleinert, Sara J. Brandt

Publikováno v: Journal of Endocrinology
J. Endocrinol. 238, R109-R119 (2018)
The Journal of Endocrinology

Obesity is a worldwide pandemic, which can be fatal for the most extremely affected individuals. Lifestyle interventions such as diet and exercise are largely ineffective and current anti-obesity medications offer little in the way of significant or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f1ddc23c962e713008dbae3ea09728
https://doi.org/10.1530/joe-18-0264

Incretin-based co- and tri-agonists Innovative polypharmacology for the treatment of obesity and diabetes

Autor: A, Harger, K, Stemmer, M H, Tschöp, T D, Müller

Publikováno v: Internist 60, 895-902 (2019)

Background The worldwide rise in overweight and obesity is paralleled by an increasing prevalence of type-2 diabetes. Apart from bariatric surgery, treatment options to decrease body weight are often underwhelming. Innovative pharmacological options

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dc78a81b479bb8c99d191f072f23675f
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56653

Peptide-based multi-agonists: a new paradigm in metabolic pharmacology

Autor: M. H. Tschöp, Richard D. DiMarchi, Timo D. Müller, Kerstin Stemmer, Sara J. Brandt

Publikováno v: Journal of Internal Medicine
J. Intern. Med. 284, 581-602 (2018)

Obesity and its comorbidities, such as type 2 diabetes, are pressing worldwide health concerns. Available anti-obesity treatments include weight loss pharmacotherapies and bariatric surgery. Whilst surgical interventions typically result in significa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb7a816ab7e4ce6ba47c3e9956cc956
https://mediatum.ub.tum.de/1524457

Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior

Autor: M. H. Tschöp, Javier E. Stern, Wagner Luis Reis, Chun-Xia Yi, Yuanqing Gao

Publikováno v: Endocrinology 156, 1303-1315 (2015)
Endocrinology, 156(4), 1303-1315. The Endocrine Society

Hypothalamic inflammation, involving microglia activation in the arcuate nucleus (ARC), is proposed as a novel underlying mechanism in obesity, insulin and leptin resistance. However, whether activated microglia affects ARC neuronal activity, and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41f9452d34b2c4a30ca46cf01d8dcaa
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=44017