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PREVENTION OF CHRONIC REJECTION IN MOUSE AORTIC ALLOGRAFTS BY COMBINED TREATMENT WITH CTLA4-Ig AND ANTI-CD40 LIGAND MONOCLONAL ANTIBODY1,2

Autor: John J. Fung, Christopher Chen, M. H. Sayegh, Peter S. Linsley, Thomas E. Starzl, Vladimir M. Subbotin, Luis A. Valdivia, H. Sun, Abdul S. Rao, A Aitouche

Publikováno v: Transplantation. 64:1838-1843

Background In this study, using a murine model of aortic allotransplantation, the role of blockade of signaling through CD28/B7 and CD40/CD40 ligand co-stimulatory pathways in the evolvement of posttransplant vasculopathy was examined. Methods. Aorti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bbe2d364b6843f901e266f643a7f23d
https://doi.org/10.1097/00007890-199712270-00035

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CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses

Autor: K Onodera, A Chandraker, M Schaub, T H Stadlbauer, S Korom, R Peach, P S Linsley, M H Sayegh, J W Kupiec-Weglinski

Publikováno v: The Journal of Immunology. 159:1711-1717

We tested the effects of blocking CD28-B7 T cell costimulation by using CTLA4Ig in an established transplantation model in which LBNF1 cardiac allografts are rejected in an accelerated manner (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8303d80355c5d59c399fd9c009a8ea8
https://doi.org/10.4049/jimmunol.159.4.1711

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The role of donor and recipient B7-1 (CD80) in allograft rejection

Autor: X X Zheng, M H Sayegh, X G Zheng, Y Li, P S Linsley, R Peach, F Borriello, T B Strom, A H Sharpe, L A Turka

Publikováno v: The Journal of Immunology. 159:1169-1173

Blockade of CD28-mediated T cell costimulatory signals produces effective immunosuppression of a variety of T cell-dependent in vivo immune responses, including autoimmune disorders and transplant rejection. The soluble fusion protein CTLA4Ig, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::114e980590d6cebb0195b162fd5863b1
https://doi.org/10.4049/jimmunol.159.3.1169

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Induction of 'infectious' tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients

Autor: K Onodera, M Lehmann, E Akalin, H D Volk, M H Sayegh, J W Kupiec-Weglinski

Publikováno v: The Journal of Immunology. 157:1944-1950

LBNF1 heart grafts are rejected in an accelerated manner within 36 h by LEW rats that have been sensitized with Brown Norway rat skin grafts on day -7. Treatment with RIB-5/2, a CD4-nondepleting mAb (10 doses of 5 mg/rat/day, i.v., from day -7 to day

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82f4fa7cae0be2ddd8df6cb16ac5e20c
https://doi.org/10.4049/jimmunol.157.5.1944

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The in vivo mechanism of action of CTLA4Ig

Autor: T A Judge, A Tang, L M Spain, J Deans-Gratiot, M H Sayegh, L A Turka

Publikováno v: The Journal of Immunology. 156:2294-2299

A single dose of CTLA4Ig, an inhibitor of CD28-mediated T cell costimulation, given 2 days after transplantation induces specific unresponsiveness to alloantigens in vivo. However, the mechanisms responsible are unknown. Using pigeon cytochrome c as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7f88c66154b36095deb36e3a09a8a9c
https://doi.org/10.4049/jimmunol.156.6.2294

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CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines

Autor: J W Kupiec-Weglinski, B Wasowska, I Papp, G Schmidbauer, M H Sayegh, W M Baldwin, K J Wieder, W W Hancock

Publikováno v: The Journal of Immunology. 151:5053-5061

The accelerated (24 h) rejection of (LEWxBN)F1 cardiac allografts (Tx) in LEW rats sensitized with BN skin grafts, is abrogated with CD4 mAb (BWH-4) administration between skin (day -7) and heart (day 0) transplantation (Tx survival ca. 11 days, p <

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ea8ab326bd1abeb52a9f923a65278bc
https://doi.org/10.4049/jimmunol.151.9.5053

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The evolution of the immunobiology of co-stimulatory pathways: clinical implications

Autor: S, Trikudanathan, M H, Sayegh

Publikováno v: Clinical and experimental rheumatology. 25(5 Suppl 46)

Co-stimulatory pathways are a prerequisite for the regulation of T-cell activation and tolerance. After the engagement of the T-cell receptor (TCR) to the major histocompatibility complex (MHC)/peptide complex, the co-stimulatory signals are critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46f6b51807f7ad28be49fc1b3b2fac14
https://pubmed.ncbi.nlm.nih.gov/17977484

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