Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M H, Ossipov"'
Autor:
T. P. Jerussi, L. V. Kudzma, H. K. Spencer, N. L. Lalinde, J. A. Colapret, M. J. Benvenga, J. R. Bagley, B.‐S. Huang, Theodore C. Spaulding, M. H. Ossipov, B. M. Doorley, B.‐S. Lin
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b52466b5347d8c0ac12bc1bf7c5b9ffd
https://doi.org/10.1002/chin.199149339
https://doi.org/10.1002/chin.199149339
Publikováno v:
Molecular interventions. 1(3)
One of the curious but common consequences of opioid administration in the clinical setting is the induction, at sites uninvolved in the original presentation of discomfort, of pain itself. The induction of pain is also a reliable, measurable phenome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00fe000ab3dc6d129f90ea1731f181e2
https://pubmed.ncbi.nlm.nih.gov/14993349
https://pubmed.ncbi.nlm.nih.gov/14993349
Publikováno v:
Methods in enzymology. 314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b087d7c3b44605c3bddecf512c2a60d
https://pubmed.ncbi.nlm.nih.gov/10565014
https://pubmed.ncbi.nlm.nih.gov/10565014
Autor:
M H, Ossipov, C J, Kovelowski, H, Wheeler-Aceto, A, Cowan, J C, Hunter, J, Lai, T P, Malan, F, Porreca
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
The present experiments explored the role of endogenous opioids in the behavioral response to a formalin-induced nociceptive stimulus in the rat. Flinching was taken as a measure of the intensity of the nociceptive stimulus after the administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93680252e09a6eab72584524305ab221
https://pubmed.ncbi.nlm.nih.gov/8627559
https://pubmed.ncbi.nlm.nih.gov/8627559
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 255(3)
The antinociceptive interaction of opiate analgesics with clonidine was examined with the tail-flick and 55 degrees C hot plate tests. Male Sprague-Dawley rats received fixed ratios of clonidine to fentanyl, meperidine or morphine by i.v. and intrath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f7b1bbf81040782557440e312a4d0b8
https://pubmed.ncbi.nlm.nih.gov/2262895
https://pubmed.ncbi.nlm.nih.gov/2262895
Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy
Publikováno v:
Anesthesiology. 73(6)
The antinociceptive interaction on the tail flick (TF) and hot plate (HP) tests between opioid analgesics and medetomidine after intravenous (iv) or intrathecal administration were examined by isobolographic analysis. Male Sprague-Dawley rats receive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19176776fe630e377f26e5c44cd16ee7
https://pubmed.ncbi.nlm.nih.gov/1978990
https://pubmed.ncbi.nlm.nih.gov/1978990
Publikováno v:
Journal of medicinal chemistry. 33(10)
The synthesis and intravenous analgesic activity of a series of 3-methyl-4-(N-phenyl amido)piperidines, entries 34-79, is described. The methoxyacetamide pharmacophore produced a series of compounds with optimal analgesic potency and short duration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bf85374972f0bfee284a332a5940512
https://pubmed.ncbi.nlm.nih.gov/2170652
https://pubmed.ncbi.nlm.nih.gov/2170652
Autor:
E. F. Ezell, M. H. Ossipov, Frieda G. Rudo, L. V. Kudzma, M. J. Benvenga, V. V. Knight, Theodore C. Spaulding, S. A. Severnak, H. K. Spencer
Publikováno v:
ChemInform. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e4cc49f5aafa98626298d5edb768206
https://doi.org/10.1002/chin.199017183
https://doi.org/10.1002/chin.199017183
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 259(2)
Using the rat tail-flick method to assess analgetic efficacy, the effects of desipramine (DMI) on analgesia produced by either systemic or central (i.e., periaqueductal gray) administration of morphine sulfate (MS) were evaluated. Pretreatment of rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb4d077a3e60821b025fdbcd525ee331
https://pubmed.ncbi.nlm.nih.gov/7181579
https://pubmed.ncbi.nlm.nih.gov/7181579
Publikováno v:
Neuropharmacology. 23(8)
Activity of opioids in cats was assessed by employing the tail-flick method. Microinjection of morphine (100 micrograms) or etorphine (2.5 micrograms) into the ventrolateral periaqueductal gray (VLPAG) region resulted in significant analgesia. Smalle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f18439aec8cb811d01edd4440ef31b2
https://pubmed.ncbi.nlm.nih.gov/6483117
https://pubmed.ncbi.nlm.nih.gov/6483117