Výsledky vyhledávání - "M H, Newberg"

Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules

Autor: M H Newberg, D H Smith, S B Haertel, D R Vining, E Lacy, V H Engelhard

Publikováno v: The Journal of Immunology. 156:2473-2480

The importance of the species of different domains of class I MHC molecules in peripheral T cell recognition and positive and negative selection was evaluated in a single system. In transgenic mice expressing AAD (containing the alpha1+alpha2 domains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0cf572b09ef7f7702041718b8d63004
https://doi.org/10.4049/jimmunol.156.7.2473

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Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules

Autor: D M Smith, J A Bluestone, D R Jeyarajah, M H Newberg, V H Engelhard, J R Thistlethwaite, E S Woodle

Publikováno v: The Journal of Immunology. 153:1054-1067

A long term goal of investigators working in our laboratory has been to develop new mAbs for use as immunosuppressive agents. As a means toward achieving this goal, several new mAbs (hybridomas) have been developed by screening fusions for supernatan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4754cd62c475f20b616cfb0462c16325
https://doi.org/10.4049/jimmunol.153.3.1054

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Species specificity in the interaction of CD8 with the alpha 3 domain of MHC class I molecules

Autor: M H Newberg, J P Ridge, D R Vining, R D Salter, V H Engelhard

Publikováno v: The Journal of Immunology. 149:136-142

The alpha 1 and alpha 2 domains of the class I MHC molecule constitute the putative binding site for processed peptides and the TCR, although the alpha 3 domain has been implicated as a binding site for the CD8 molecule. Species specificity in the bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23809bd82ccc51c81c549b773fb0d882
https://doi.org/10.4049/jimmunol.149.1.136

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Use of gene therapy to suppress the antigen-specific immune responses in mice to an HLA antigen

Autor: I K, Schumacher, M H, Newberg, J D, Jackson, J M, Hammel, R J, Rubocki, V H, Engelhard, I J, Fox

Publikováno v: Transplantation. 62(6)

Hematopoietic chimerism has been used in the laboratory to induce life-long immunologic tolerance to donor antigens. The present study demonstrates that mice transplanted with autologous bone marrow cells retrovirally transduced to express HLA-A2.1 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7336ea24005b95bc750c2ff99d5d1f71
https://pubmed.ncbi.nlm.nih.gov/8824485

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