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Akademický článek

Electronic damage in S atoms in a native protein crystal induced by an intense X-ray free-electron laser pulse

Publikováno v: Structural Dynamics, Vol 2, Iss 4, Pp 041703-041703-8 (2015)

Current hard X-ray free-electron laser (XFEL) sources can deliver doses to biological macromolecules well exceeding 1 GGy, in timescales of a few tens of femtoseconds. During the pulse, photoionization can reach the point of saturation in which c

Externí odkaz: https://doaj.org/article/98de9c6dd27d4e1dbb6396e48ef9fce7

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Voltage dependent activation of potassium channels is coupled to T1 domain structure

Autor: S J, Cushman, M H, Nanao, A W, Jahng, D, DeRubeis, S, Choe, P J, Pfaffinger

Publikováno v: Nature structural biology. 7(5)

The T1 domain, a highly conserved cytoplasmic portion at the N-terminus of the voltage-dependent K+ channel (Kv) alpha-subunit, is responsible for driving and regulating the tetramerization of the alpha-subunits. Here we report the identification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4040f0fca708e2bee188227a97dcb708
https://pubmed.ncbi.nlm.nih.gov/10802739

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Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels

Autor: K A, Bixby, M H, Nanao, N V, Shen, A, Kreusch, H, Bellamy, P J, Pfaffinger, S, Choe

Publikováno v: Nature structural biology. 6(1)

The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated K+ channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Crystal structures of T1 tetramers from Shaw an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a09ac1bc8a5049073698ecabd66669a5
https://pubmed.ncbi.nlm.nih.gov/9886290

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