Výsledky vyhledávání - "M H, Holguin"

Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositol-anchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction

Autor: Charles J. Parker, John P. Atkinson, M H Holguin, Gregory T. Spear, Tarlan Hedayati, Mohammed Saifuddin

Publikováno v: Journal of General Virology. 78:1907-1911

Human immunodeficiency virus type 1 (HIV-1) can be either resistant or sensitive to complement-mediated destruction depending on the host cells. Incorporation of different levels of host cell CD46, CD55 and CD59 may account for this differential sens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f4b659f0626604025c18024d1be2dd
https://doi.org/10.1099/0022-1317-78-8-1907

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Analysis of the gene that encodes the complement regulatory protein, membrane inhibitor of reactive lysis (CD59). Identification of an alternatively spliced exon and characterization of the transcriptional regulatory regions of the promoter

Autor: M H Holguin, C B Martin, T Eggett, C J Parker

Publikováno v: The Journal of Immunology. 157:1659-1668

Membrane inhibitor of reactive lysis (MIRL, CD59) is an 18-kDa glycosylphosphatidylinositol-anchored protein that regulates formation of the membrane attack complex of complement. The purpose of these studies was to characterize the gene that encodes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af90ae3bc5175ff34ff7a9cba1158bc9
https://doi.org/10.4049/jimmunol.157.4.1659

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Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria

Autor: Akira Tomita, Shashi P. Singh, Morito Endo, Russell E. Ware, Charles J. Parker, M H Holguin, Thad A. Howard, Teresa M. Vreeke

Publikováno v: Blood. 87:2546-2557

The purpose of these studies was to determine the molecular basis of the phenotypic mosaicism that is a defining feature of paroxysmal nocturnal hemoglobinuria (PNH). Analysis of T cell clones from a female patient revealed four distinct phenotypes b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ad99f5d58508e3c61bf49e2455b1749
https://doi.org/10.1182/blood.v87.6.2546.bloodjournal8762546

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Enhanced expression of the complement regulatory protein, membrane inhibitor of reactive lysis (CD59), is regulated at the level of transcription

Autor: Charles J. Parker, Carol B. Martin, John H. Weis, M H Holguin

Publikováno v: Blood. 82:968-977

The membrane inhibitor of reactive lysis (MIRL) is an 18-Kd glycosyl phosphatidylinositol anchored membrane glycoprotein that inhibits the cytolytic activity of complement. MIRL is expressed by all hematopoietic elements and by a wide variety of nonh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b648972eeeead300ef4919e518f45d22
https://doi.org/10.1182/blood.v82.3.968.968

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Analysis of the effects of activation of the alternative pathway of complement on erythrocytes with an isolated deficiency of decay accelerating factor

Autor: M H Holguin, C B Martin, N J Bernshaw, C J Parker

Publikováno v: The Journal of Immunology. 148:498-502

E from individuals with the Inab blood group phenotype have an isolated deficiency of decay accelerating factor (DAF, CD55). DAF is a glycosyl phosphatidylinositol anchored membrane protein that inhibits activation of both the classical and alternati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::833d25238a87f29f7b94a20f6b96a32c
https://doi.org/10.4049/jimmunol.148.2.498

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Loss of human CR1- and murine Crry-like exons in human CR2 transcripts due to CR2 gene mutations

Autor: M H Holguin, C B Kurtz, C J Parker, J J Weis, J H Weis

Publikováno v: The Journal of Immunology. 145:1776-1781

Analysis of the coding sequences of the murine Cr2 gene indicated that it contains two distinct regions of homology to the murine Crry, and human CR1 and CR2 genes. The last 15 short consensus repeats (SCR) of Cr2 are very similar to the 15 reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d6a2cddc0c71ca1ff71d761bd1e01cb
https://doi.org/10.4049/jimmunol.145.6.1776

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Erythrocyte membrane inhibitor of reactive lysis: effects of phosphatidylinositol-specific phospholipase C on the isolated and cell- associated protein

Autor: Charles J. Parker, M H Holguin, L A Wilcox, WF Rosse, N J Bernshaw

Publikováno v: Blood. 75:284-289

The erythrocyte membrane inhibitor of reactive lysis (MIRL) is an 18-Kd protein that controls complement-mediated hemolysis by restricting the activity of the membrane attack complex. MIRL expression on the erythrocytes of paroxysmal nocturnal hemogl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cab5534e6f0dfa9e278fa8d4ec85574
https://doi.org/10.1182/blood.v75.1.284.284

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Autor: M H, Holguin, C B, Martin, T, Eggett, C J, Parker

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c91aa647cb85413740c6eb783ef9dd40
https://pubmed.ncbi.nlm.nih.gov/8759753

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Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria

Autor: M, Endo, R E, Ware, T M, Vreeke, S P, Singh, T A, Howard, A, Tomita, M H, Holguin, C J, Parker

Publikováno v: Blood. 87(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de5e651d653d3d7a572328cd771423ed
https://pubmed.ncbi.nlm.nih.gov/8630422

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Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone

Autor: W G, Harker, D L, Slade, R L, Parr, M H, Holguin

Publikováno v: Cancer research. 55(21)

Topoisomerase II alpha is an essential nuclear enzyme involved in DNA replication and a target for many of the clinically useful antineoplastic agents. In a mitoxantrone-selected human leukemia cell line, HL-60/MX2, cellular topoisomerase II (topo II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b93c93634e45f55599cfdb829e4d23aa
https://pubmed.ncbi.nlm.nih.gov/7585537

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