Zobrazeno 1 - 10 of 78 pro vyhledávání: '"M H, Ginsberg"'
1
Integrin Activation
Autor: S. Liu, D. G. Woodside, M. H. Ginsberg
Publikováno v: Thrombosis and Haemostasis. 86:316-323
SummaryIntegrins are cell surface adhesion receptors that participate in a variety of important processes throughout the vasculature. Here we summarize some recent findings on the regulation of integrin mediated cellular adhesion. Particular emphasis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab2e9c419bac10ca3d794b5861f1de20
https://doi.org/10.1055/s-0037-1616229
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2
Platelet glycoprotein IIb-IIIa (alpha IIb beta 3 integrin) confers fibrinogen- and activation-dependent aggregation on heterologous cells
Autor: M M, Frojmovic, T E, O'Toole, E F, Plow, J C, Loftus, M H, Ginsberg
Publikováno v: Blood. 78:369-376
To analyze molecular mechanisms of platelet aggregation, we have studied the aggregation of Chinese hamster ovary (CHO) cells expressing between 1 and 4 x 10(5) recombinant human glycoprotein (GP) IIb-IIIa molecules per cell (A5 cells). These cells a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3c4c2df2c75b644b3c3cae41235656
https://doi.org/10.1182/blood.v78.2.369.bloodjournal782369
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3
Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies
Autor: M H, Ginsberg, A L, Frelinger, S C, Lam, J, Forsyth, R, McMillan, E F, Plow, S J, Shattil
Publikováno v: Blood. 76:2017-2023
Normal primary platelet aggregation requires agonist-mediated activation of membrane GPIIb-IIIa, binding of fibrinogen to GPIIb-IIIa, and cellular events after ligand binding. PAC1 monoclonal antibody distinguishes between resting and activated state
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c22877e809da70bbebfd6848d27e9
https://doi.org/10.1182/blood.v76.10.2017.bloodjournal76102017
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4
Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1)
Autor: J H, Peters, L A, Sporn, M H, Ginsberg, D D, Wagner
Publikováno v: Blood. 75:1801-1808
Cellular fibronectin (Fn) bearing an alternatively spliced extra type III structural repeat (ED1) is normally present at low concentrations in blood plasma. The source of this material remains uncertain. In this study, primary cultures of human umbil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35beab925d6cf8e9b59c96b1bed5352
https://doi.org/10.1182/blood.v75.9.1801.bloodjournal7591801
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5
The affinity of integrin alpha(4)beta(1) governs lymphocyte migration
Autor: D M, Rose, V, Grabovsky, R, Alon, M H, Ginsberg
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 167(5)
The interaction of integrin alpha(4)beta(1) with endothelial VCAM-1 controls the trafficking of lymphocytes from blood into peripheral tissues. Cells actively regulate the affinity of alpha(4)beta(1) for VCAM-1 (activation). To investigate the biolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::230c0fc3b3ff8b94dc3d575dc9158af2
https://pubmed.ncbi.nlm.nih.gov/11509628
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6
Integrin activation
Autor: D G, Woodside, S, Liu, M H, Ginsberg
Publikováno v: Thrombosis and haemostasis. 86(1)
Integrins are cell surface adhesion receptors that participate in a variety of important processes throughout the vasculature. Here we summarize some recent findings on the regulation of integrin mediated cellular adhesion. Particular emphasis is pla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27405269c6fccfab1212c2b9d284141b
https://pubmed.ncbi.nlm.nih.gov/11487020
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8
Soluble VCAM-1 binding to alpha4 integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells
Autor: D M, Rose, P M, Cardarelli, R R, Cobb, M H, Ginsberg
Publikováno v: Blood. 95(2)
Soluble vascular cell adhesion molecule-1 (sVCAM-1) is generated during inflammation and can alter lymphocyte functions. The authors report that the binding of sVCAM-1 to alpha4 integrin-bearing cells is a dynamically regulated, active cellular proce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd4c597b217dffe77f31038fdaf8ffd8
https://pubmed.ncbi.nlm.nih.gov/10627469
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9
Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow
Autor: B, Savage, M H, Ginsberg, Z M, Ruggeri
Publikováno v: Blood. 94(8)
We have used real-time video microscopy to study the mechanisms of platelet adhesion to type I collagen fibrils of distinct structure exposed to flowing blood. Electron microscopy analysis by surface replication demonstrated morphological differences
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e319db37a6e84d83d51606b7e76612db
https://pubmed.ncbi.nlm.nih.gov/10515874
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10
A mutation in the alpha subunit of the platelet integrin alphaIIbbeta3 identifies a novel region important for ligand binding
Autor: E C, Tozer, E K, Baker, M H, Ginsberg, J C, Loftus
Publikováno v: Blood. 93(3)
An unbiased genetic approach was used to identify a specific amino acid residue in the alphaIIb subunit important for the ligand binding function of the integrin alphaIIbbeta. Chemically mutagenized cells were selected by flow cytometry based on thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ba0bbd2e3d59207c32208ed27f3f3d4
https://pubmed.ncbi.nlm.nih.gov/9920841
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