Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M Guy Roukens"'
Autor:
Stephin J Vervoort, Olivier G de Jong, M Guy Roukens, Cynthia L Frederiks, Jeroen F Vermeulen, Ana Rita Lourenço, Laura Bella, Ana Tufegdzic Vidakovic, José L Sandoval, Cathy Moelans, Miranda van Amersfoort, Margaret J Dallman, Alejandra Bruna, Carlos Caldas, Edward Nieuwenhuis, Elsken van der Wall, Patrick Derksen, Paul van Diest, Marianne C Verhaar, Eric W-F Lam, Michal Mokry, Paul J Coffer
Publikováno v:
eLife, Vol 7 (2018)
The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms underlying the pro-oncogeni
Externí odkaz:
https://doaj.org/article/36ce755b8cc24e3d9cea3f932f2ee24e
Autor:
Antoine A. Khalil, Daan Smits, Peter D. Haughton, Thijs Koorman, Karin A. Jansen, Mathijs P. Verhagen, Mirjam van der Net, Kitty van Zwieten, Lotte Enserink, Lisa Jansen, Abdelrahman G. El-Gammal, Daan Visser, Milena Pasolli, Max Tak, Denise Westland, Paul J. van Diest, Cathy B. Moelans, M. Guy Roukens, Sandra Tavares, Anne-Marie Fortier, Morag Park, Riccardo Fodde, Martijn Gloerich, Fried. J. T. Zwartkruis, Patrick WB. Derksen, Johan de Rooij
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristic
Externí odkaz:
https://doaj.org/article/50e49d8f27e74b6aa43d0874b11c6389
Autor:
Ana Rita Lourenço, M. Guy Roukens, Danielle Seinstra, Cynthia L. Frederiks, Cornelieke E. Pals, Stephin J. Vervoort, Andreia S. Margarido, Jacco van Rheenen, Paul J. Coffer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.
Externí odkaz:
https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b
Autor:
Lydia S. Schulla, E. Diana Alupoaie, Leanne De Silva, Debby Gawlitta, Sabine Middendorp, Paul J. Coffer, M. Guy Roukens
Organoids hold great potential for regenerative medicine and biomedical research. While they are able to recapitulate many structural and functional aspects of their in vivo counterparts, they lack a functional vasculature. In this study, we aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8803f1c2017c6ec6a3b7e09bf4d6fd94
https://doi.org/10.1101/2022.03.25.485813
https://doi.org/10.1101/2022.03.25.485813
Autor:
M Guy Roukens, Jeroen F. Vermeulen, Cynthia L Frederiks, Margaret J. Dallman, Michal Mokry, Miranda van Amersfoort, Cathy B. Moelans, Ana Rita Lourenço, Carlos Caldas, Eric Lam, Edward E. S. Nieuwenhuis, Paul J. van Diest, Stephin J. Vervoort, Olivier G. de Jong, Elsken van der Wall, Alejandra Bruna, Paul J. Coffer, Laura Bella, Patrick W. B. Derksen, José Luis Sandoval, Marianne C. Verhaar, Ana Tufegdzic Vidakovic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e77ccb0abc065b87f26a5e51d97c3e3a
https://doi.org/10.7554/elife.27706.036
https://doi.org/10.7554/elife.27706.036
Autor:
Stefan Schulte-Merker, Michael Jeltsch, Veli-Matti Leppänen, Yvonne Padberg, Kari Alitalo, Josi Peterson-Maduro, M. Guy Roukens, Frank L. Bos, Dörte Schulte
Publikováno v:
Circulation Research, 116(10), 1660. Lippincott Williams and Wilkins
Rationale : Collagen- and calcium-binding EGF domain–containing protein 1 (CCBE1) is essential for lymphangiogenesis in vertebrates and has been associated with Hennekam syndrome. Recently, CCBE1 has emerged as a crucial regulator of vascular endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfaa06a9ab3adc625b01b56e0fd6642
https://doi.org/10.1161/circresaha.116.304949
https://doi.org/10.1161/circresaha.116.304949
Autor:
Dörte Schulte, Fiona Connell, Pia Ostergaard, Stefan Schulte-Merker, Kristiana Gordon, Michael A. Simpson, Steve Jeffery, Peter S. Mortimer, M. Guy Roukens, Andreas van Impel, Kamini Kalidas, Glen Brice, Sahar Mansour
Publikováno v:
Circulation Research, 112(6), 956-960. Lippincott Williams & Wilkins
Rationale: Mutations in vascular endothelial growth factor (VEGF) receptor-3 ( VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema. Mutations in VEGFR3 are identified in only 70% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229a374d4eba5f2c1831f93231aa5460
https://doi.org/10.1161/circresaha.113.300350
https://doi.org/10.1161/circresaha.113.300350
Autor:
Elke A. Ober, Henricus J. Duckers, Dorien M. A. Hermkens, Stefan Schulte-Merker, Johanna C. Fischer, Zhonghua Zhao, Andreas van Impel, Josi Peterson-Maduro, M. Guy Roukens, Philip W. Ingham
Publikováno v:
Development, 141(6), 1228-38. Company of Biologists Ltd
Development 141 (2014)
Development, 141, 1228-1238
Development 141 (2014)
Development, 141, 1228-1238
In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. Its restricted expression in a subset of cardinal vein cells leads to a switch towards lymphatic specification and hence represents a prerequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc80da3e2de117ddd776c525b03b9e4
https://pure.knaw.nl/portal/en/publications/131a6800-348d-4230-9cc7-4f3cb8c136cc
https://pure.knaw.nl/portal/en/publications/131a6800-348d-4230-9cc7-4f3cb8c136cc
Autor:
Stefan Schulte-Merker, Bart Baan, Josi Peterson-Maduro, Hans van Dam, Mariam Alloul-Ramdhani, M. Guy Roukens, Kazuki Kobayashi, David Baker
Publikováno v:
Nature Cell Biology, 12(10), 933-942. Nature Publishing Group
Nature Cell Biology, 12(10), 933-942
Nature cell biology, 12(10), 933-942. Nature Publishing Group
Nature Cell Biology, 12(10), 933-942
Nature cell biology, 12(10), 933-942. Nature Publishing Group
We show that the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system. Tel orches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afac2d19ac5a6dfef0f4b9050fba2e4
https://doi.org/10.1038/ncb2096
https://doi.org/10.1038/ncb2096
Autor:
M. Guy Roukens, Marjolein Op den Brouw, Mariam Alloul-Ramdhani, David Baker, Setareh Moghadasi
The vertebrate Ets transcriptional repressor Tel (ETV6) and its invertebrate orthologue, Yan, are both indispensable for development, and they orchestrate cell growth and differentiation by binding to DNA, thus inhibiting gene expression. To trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b0aac508d60b272b11fdda28405f80
https://europepmc.org/articles/PMC2447152/
https://europepmc.org/articles/PMC2447152/