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Computational Methods for Single-Cell Proteomics

Autor: Sophia M. Guldberg, Trine Line Hauge Okholm, Elizabeth E. McCarthy, Matthew H. Spitzer

Publikováno v: Annual Review of Biomedical Data Science. 6

Advances in single-cell proteomics technologies have resulted in high-dimensional datasets comprising millions of cells that are capable of answering key questions about biology and disease. The advent of these technologies has prompted the developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0245327a9aceaa176998abb7721cff20
https://doi.org/10.1146/annurev-biodatasci-020422-050255

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T cell-instructed inflammation drives immune checkpoint inhibitor therapy resistance

Autor: Nam Woo Cho, Sophia M. Guldberg, Eun Ji Kim, Kamir J. Hiam-Galvez, Katherine Wai, Lauren S. Levine, Barzin Y. Nabet, Rachel DeBarge, Jacqueline L. Yee, Naa Asheley Ashitey, Iliana Tenvooren, Matthew H. Spitzer

Even in patients whose tumours exhibit increased T cell infiltration, resistance to immune checkpoint inhibitor (ICI) therapy is common. We investigated mechanisms of ICI resistance using engineered mouse models with increased neoantigen burden and T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb603281f9788dc9e6c4674727a9aaf6
https://doi.org/10.1101/2022.09.20.508732

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Immunological Properties of Protein–Polymer Nanoparticles

Autor: Mitra S. Ganewatta, M. G. Finn, Jukuan Zheng, Theresa M. Reineke, Stephen N. Crooke, Sophia M. Guldberg

Publikováno v: ACS Applied Bio Materials. 2:93-103

The covalent attachment of polymers to the surface of proteins and nanoparticles has been widely employed in the development of biomedical platforms capable of delaying or diminishing immune surveillance. The most widely employed polymer for these ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f45984a0929a48263b47d64323d209e
https://doi.org/10.1021/acsabm.8b00418

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Measurement of Microcystin and Nodularin Activity in Human Urine by Immunocapture-Protein Phosphatase 2A Assay

Autor: Sophia M. Guldberg, Elizabeth I. Hamelin, Rudolph C. Johnson, Rebekah E. Wharton, Brady R. Cunningham, Adam M. Schaefer

Publikováno v: Toxins
Volume 11
Issue 12

Microcystins (MC) and nodularin (NOD) are toxins released by cyanobacteria during harmful algal blooms. They are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A) and cause a variety of adverse symptoms in humans and animals if ingest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b7e9a6674e213dda4dff0fc5283a9e
https://doi.org/10.3390/toxins11120729

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The Biopersistence and Pathogenicity of Man-made Vitreous Fibres after Short- and Long-term Inhalation

Autor: O. Kamstrup, M. Guldberg, A. Ellehauge, J. M. G. Davis

Publikováno v: The Annals of Occupational Hygiene. 42:191-199

A summary is given of the biopersistence and pathology after inhalation by rats of two different Man–made Vitreous Fibres, MMVF10 (traditional stone wool) and MMVF23 (HT stone wool), and the results are discussed in relation to biopersistence measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03feb60c59ed4da18ef7f44a80e4f34
https://doi.org/10.1016/s0003-4878(98)00019-2

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