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of 10 366
pro vyhledávání: '"M Grover"'
Autor:
Amy J Naylor, Simon W Jones, Liam M Grover, Thomas Nicholson, James Edwards, Kieran Patrick, Jonathan W Lewis, Hannah C Lamont, Kathryn Frost, Binal Patel, Miruna Chipara, Laurence A Hill, Georgiana Neag, Melissa Finlay
Publikováno v:
F1000Research, Vol 12 (2024)
Background There are insufficient in vitro bone models that accommodate long-term culture of osteoblasts and support their differentiation to osteocytes. The increased demand for effective therapies for bone diseases, and the ethical requirement to r
Externí odkaz:
https://doaj.org/article/6df289861d374cf88443e970916419f1
Autor:
Amy J Naylor, Simon W Jones, Liam M Grover, Thomas Nicholson, James Edwards, Kieran Patrick, Jonathan W Lewis, Hannah C Lamont, Kathryn Frost, Binal Patel, Miruna Chipara, Laurence A Hill, Georgiana Neag, Melissa Finlay
Publikováno v:
F1000Research, Vol 12 (2024)
Background There are insufficient in vitro bone models that accommodate long-term culture of osteoblasts and support their differentiation to osteocytes. The increased demand for effective therapies for bone diseases, and the ethical requirement to r
Externí odkaz:
https://doaj.org/article/b76abd1f90334018a55f178824171e2b
Autor:
Scott P. Davies, Vincenzo Ronca, Grace E. Wootton, Natalia M. Krajewska, Amber G. Bozward, Rémi Fiancette, Daniel A. Patten, Katharina Yankouskaya, Gary M. Reynolds, Sofia Pat, Daniel C. Osei-Bordom, Naomi Richardson, Liam M. Grover, Christopher J. Weston, Ye H. Oo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we characterise the mechanism of CD8+ T cell invasion into BEC.
Externí odkaz:
https://doaj.org/article/8c5d5d80fa404d79a9d64d2f03722925
Autor:
Stéphanie R. do Amaral, Camila F. Amantino, Aleksandar Atanasov, Stefanie Oliveira Sousa, Richard Moakes, Sonia Maria Oliani, Liam M. Grover, Fernando L. Primo
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1169 (2024)
Skin inflammation associated with chronic diseases involves a direct role of keratinocytes in its immunopathogenesis, triggering a cascade of immune responses. Despite this, highly targeted treatments remain elusive, highlighting the need for more sp
Externí odkaz:
https://doaj.org/article/820fc01d033f4853a3dc573690653327
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Heterotopic ossification (HO), the pathological formation of bone in soft tissues, is a debilitating condition, as well as one of the few instances of de novo bone formation in adults. Chemical mapping of HO tissue showed distinct islands of
Externí odkaz:
https://doaj.org/article/320dcc4f76174437a2b06e356a0baefc
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Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0291284 (2024)
The impact of environmental uncertainty on locomotor adaptation remains unclear. Environmental uncertainty could either aid locomotor adaptation by prompting protective control strategies that stabilize movements to assist learning or impede adaptati
Externí odkaz:
https://doaj.org/article/5a2daeeaa1694bb0871d375a4d926c11
Autor:
Thomas E. Robinson, Mathieu Y. Brunet, Iain Chapple, Adrian H. M. Heagerty, Anthony D. Metcalfe, Liam M. Grover
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 9, Pp n/a-n/a (2023)
Fibrotic diseases account for 45% of all deaths in the developed world, and progressive scarring conditions, such as dystrophic epidermolysis bullosa (EB), result in a significant reduction in quality of life. There is thus a need for novel approache
Externí odkaz:
https://doaj.org/article/dfac4e27a1f3466daebe338d236ee8db
Autor:
Richard J. A. Moakes, Jessica J. Senior, Thomas E. Robinson, Miruna Chipara, Aleksandar Atanasov, Amy Naylor, Anthony D. Metcalfe, Alan M. Smith, Liam M. Grover
Publikováno v:
APL Bioengineering, Vol 7, Iss 2, Pp 029901-029901-1 (2023)
Externí odkaz:
https://doaj.org/article/cdae3640089c4f31a95871dfbe3a277c
Autor:
Helen J. Knowles, Anastasios Chanalaris, Argyro Koutsikouni, Adam P. Cribbs, Liam M. Grover, Philippa A. Hulley
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionFor decades, functional primary human osteocyte cultures have been crucially needed for understanding their role in bone anabolic processes and in endocrine phosphate regulation via the bone-kidney axis. Mature osteocyte proteins (scleros
Externí odkaz:
https://doaj.org/article/f76983696b6b4de29524472273038da5