Zobrazeno 1 - 10
of 198
pro vyhledávání: '"M Gregory Forest"'
Autor:
Benjamin Walker, Dane Taylor, Josh Lawrimore, Caitlin Hult, David Adalsteinsson, Kerry Bloom, M Gregory Forest
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1007124 (2019)
Our understanding of how chromosomes structurally organize and dynamically interact has been revolutionized through the lens of long-chain polymer physics. Major protein contributors to chromosome structure and dynamics are condensin and cohesin that
Externí odkaz:
https://doaj.org/article/8c4ca5008b024fc482a2954979b6fedd
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 8, p e1004872 (2016)
A multi-mode nonlinear constitutive model for mucus is constructed directly from micro- and macro-rheology experimental data on cell culture mucus, and a numerical algorithm is developed for the culture geometry and idealized cilia driving conditions
Externí odkaz:
https://doaj.org/article/52db15e828c542008553a6dc4f2081e1
Autor:
Maryna Kapustina, Denis Tsygankov, Jia Zhao, Timothy Wessler, Xiaofeng Yang, Alex Chen, Nathan Roach, Timothy C Elston, Qi Wang, Ken Jacobson, M Gregory Forest
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004841 (2016)
Cells transition from spread to rounded morphologies in diverse physiological contexts including mitosis and mesenchymal-to-amoeboid transitions. When these drastic shape changes occur rapidly, cell volume and surface area are approximately conserved
Externí odkaz:
https://doaj.org/article/3c316e0b612544a8b7c41d1280ff16ac
Autor:
Alex Chen, Scott A McKinley, Feng Shi, Simi Wang, Peter J Mucha, Dimple Harit, M Gregory Forest, Samuel K Lai
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131351 (2015)
Secretory immunoglobulin A (sIgA), a dimeric antibody found in high quantities in the gastrointestinal mucosa, is broadly associated with mucosal immune protection. A distinguishing feature of sIgA is its ability to crosslink pathogens, thereby creat
Externí odkaz:
https://doaj.org/article/c9d34f21d91c46c8aa31f53f7da85e53
Autor:
Yunxiang Zhu, Lubna H Abdullah, Sean P Doyle, Kristine Nguyen, Carla M P Ribeiro, Paula A Vasquez, M Gregory Forest, Michael I Lethem, Burton F Dickey, C William Davis
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127267 (2015)
Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial epithelial cell cultures (HBECCs), maximal agonist-stimulated secretion exceeds
Externí odkaz:
https://doaj.org/article/23c76bc6f5944e9f97db43bcc1a2d973
Autor:
Scott A McKinley, Alex Chen, Feng Shi, Simi Wang, Peter J Mucha, M Gregory Forest, Samuel K Lai
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100598 (2014)
Eliciting broadly neutralizing antibodies (bnAb) in cervicovaginal mucus (CVM) represents a promising "first line of defense" strategy to reduce vaginal HIV transmission. However, it remains unclear what levels of bnAb must be present in CVM to effec
Externí odkaz:
https://doaj.org/article/334bb602899c4bd484c7f215d456b7ab
Autor:
David B Hill, Paula A Vasquez, John Mellnik, Scott A McKinley, Aaron Vose, Frank Mu, Ashley G Henderson, Scott H Donaldson, Neil E Alexis, Richard C Boucher, M Gregory Forest
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87681 (2014)
In human airways diseases, including cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD), host defense is compromised and airways inflammation and infection often result. Mucus clearance and trapping of inhaled pathogens constitute
Externí odkaz:
https://doaj.org/article/ce8d29f295e04fa896950ea15f3f38ea
Autor:
Leyi Zhang, Han Cao, Karen Medlin, Jason Pearson, Andreas C. Aristotelous, Alexander Chen, Timothy Wessler, M. Gregory Forest
Publikováno v:
Viruses, Vol 16, Iss 1, p 69 (2023)
Throughout the COVID-19 pandemic, an unprecedented level of clinical nasal swab data from around the globe has been collected and shared. Positive tests have consistently revealed viral titers spanning six orders of magnitude! An open question is whe
Externí odkaz:
https://doaj.org/article/f5657257e6f04c84ad570d15232719b8
Autor:
Matthew R. Markovetz, Ian C. Garbarine, Cameron B. Morrison, William J. Kissner, Ian Seim, M. Gregory Forest, Micah J. Papanikolas, Ronit Freeman, Agathe Ceppe, Andrew Ghio, Neil E. Alexis, Stephen M. Stick, Camille Ehre, Richard C. Boucher, Charles R. Esther, Marianne S. Muhlebach, David B. Hill
Publikováno v:
Journal of Cystic Fibrosis. 21:959-966
Mucus hyperconcentration in cystic fibrosis (CF) lung disease is marked by increases in both mucin and DNA concentration. Additionally, it has been shown that half of the mucins present in bronchial alveolar lavage fluid (BALF) from preschool-aged CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d562eb564d7ab44b49b3eecdcbe0ec29
https://doi.org/10.1016/j.jcf.2022.04.008
https://doi.org/10.1016/j.jcf.2022.04.008
Autor:
Anne M. Talkington, Morgan D. McSweeney, Timothy Wessler, Marielle K. Rath, Zibo Li, Tao Zhang, Hong Yuan, Jonathan E. Frank, M. Gregory Forest, Yanguang Cao, Samuel K. Lai
Publikováno v:
J Control Release
PEGylation is routinely used to extend the systemic circulation of various protein therapeutics and nanomedicines. Nonetheless, mounting evidence is emerging that individuals exposed to select PEGylated therapeutics can develop antibodies specific to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a16071e342a2ef36c658963c3c29f1
https://doi.org/10.1016/j.jconrel.2022.01.022
https://doi.org/10.1016/j.jconrel.2022.01.022