Zobrazeno 1 - 10
of 37
pro vyhledávání: '"M Gregor Madej"'
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156392 (2016)
Bacterial sugar symporters in the Major Facilitator Superfamily (MFS) use the H+ (and in a few cases Na+) electrochemical gradients to achieve active transport of sugar into the cell. Because a number of structures of MFS sugar symporters have been s
Externí odkaz:
https://doaj.org/article/1931cb7e20264ad9bc8500f26913829f
Autor:
Algirdas Miksys, Lifei Fu, M. Gregor Madej, Duarte N. Guerreiro, Susann Kaltwasser, Maria Conway, Sema Ejder, Astrid Bruckmann, Jon Marles-Wright, Richard J. Lewis, Conor O’Byrne, Jan Pané-Farré, Christine Ziegler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Cryo-EM structures of the stress-sensing complex in Listeria innocua reveal conformational changes that initiate the signaling response to environmental stress.
Externí odkaz:
https://doaj.org/article/faa9afa773db4d11bf6a756c291707a8
Autor:
Veronika Heinz, Wenke Jäckel, Susann Kaltwasser, Laura Cutugno, Patricia Bedrunka, Anica Graf, Alexander Reder, Stephan Michalik, Vishnu M. Dhople, M. Gregor Madej, Maria Conway, Marcus Lechner, Katharina Riedel, Gert Bange, Aoife Boyd, Uwe Völker, Richard J. Lewis, Jon Marles-Wright, Christine Ziegler, Jan Pané-Farré
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A cryo-electron microscopy reconstruction of a stressosome complex from a Gram-negative bacterium, Vibrio vulnificus, reveals variations in subunit composition and symmetry, which could serve to adjust the activation threshold in the response to low
Externí odkaz:
https://doaj.org/article/0034be498cef4e58a23a52ceb08946ea
Autor:
Felix Grünberger, Robert Reichelt, Ingrid Waege, Verena Ned, Korbinian Bronner, Marcell Kaljanac, Nina Weber, Zubeir El Ahmad, Lena Knauss, M. Gregor Madej, Christine Ziegler, Dina Grohmann, Winfried Hausner
Publikováno v:
Frontiers in Microbiology, Vol 11 (2021)
Although copper is in many cases an essential micronutrient for cellular life, higher concentrations are toxic. Therefore, all living cells have developed strategies to maintain copper homeostasis. In this manuscript, we have analyzed the transcripto
Externí odkaz:
https://doaj.org/article/c9078bfab54341d7a97a59cb7ccc6bcc
Autor:
Florian Sure, Marko Bertog, Sara Afonso, Alexei Diakov, Ralf Rinke, M. Gregor Madej, Sabine Wittmann, Thomas Gramberg, Christoph Korbmacher, Alexandr V. Ilyaskin
The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β-, and γ-subunits. Channel activation requires proteolytic release of inhibitory tracts from the extracellular domains of α-ENaC and γ-ENaC; however, the proteases involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1647ad897ede0e49595e59a2dbc68df
https://epub.uni-regensburg.de/52234/
https://epub.uni-regensburg.de/52234/
Publikováno v:
The Journal of Biological Chemistry
Bacterial transporters are difficult to study using conventional electrophysiology because of their low transport rates and the small size of bacterial cells. Here, we applied solid-supported membrane–based electrophysiology to derive kinetic param
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173ab5f163d13e9c80e23eacd2a83eef
http://europepmc.org/articles/PMC8784342
http://europepmc.org/articles/PMC8784342
Autor:
Tina Stumpp, Stefan Somlo, Magdalena M. Mair, Ralph Witzgall, Denise Schmied, Michael Schober, Christoph Korbmacher, Marion Kubitza, Uwe de Vries, Melanie Grosch, Markus Moser, Alexandr V. Ilyaskin, Kerstin N. Schmidt, Thaissa Dantas Pessoa, M. Gregor Madej, Karl Kunzelmann, Tobias Staudner, Helga Othmen, Katrin Brunner, Silke Haerteis, Larissa Osten, Christine Ziegler
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Mutations in the PKD2 gene cause autosomal-dominant polycystic kidney disease but the physiological role of polycystin-2, the protein product of PKD2, remains elusive. Polycystin-2 belongs to the transient receptor potential (TRP) family of non-selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4fd48c1c766e87d3fe6f1f0fe1a9ce
http://europepmc.org/articles/PMC8435292
http://europepmc.org/articles/PMC8435292
Autor:
Christine Ziegler, M. Gregor Madej
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:213-225
Cryo-electron microscopy (cryo-EM) permits the determination of atomic protein structures by averaging large numbers of individual projection images recorded at cryogenic temperatures-a method termed single-particle analysis. The cryo-preservation tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd9b76def4265ef3cf3fb555ecd93fc
https://doi.org/10.1007/s00424-018-2107-2
https://doi.org/10.1007/s00424-018-2107-2
Autor:
Juha T. Huiskonen, Martin Wilkes, Christine Ziegler, Sabine Ruppel, Ashley C. W. Pike, Rebecca M Richter, Werner Kühlbrandt, Ralph Witzgall, Daniel Rhinow, Elisabeth P. Carpenter, Friederike Joos, Marina Grieben, M. Gregor Madej, Veronika Heinz, Lydia Kreuter, Silvia De Sanctis
Publikováno v:
Nature Structural & Molecular Biology. 24:123-130
Cryo-EM structures of full-length human PC2 reveal two distinct channel states: an open conformation and a blocked conformation with Ca2+ bound at the entrance of the selectivity filter. Polycystin-2 (PC2), a calcium-activated cation TRP channel, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d241443c3776e19b0e41c0e418a7fa
https://doi.org/10.1038/nsmb.3357
https://doi.org/10.1038/nsmb.3357
Autor:
M. Gregor Madej
Publikováno v:
Advances in Biology. 2014:1-20
The major facilitator superfamily (MFS) is a diverse group of secondary transporters with members found in all kingdoms of life. A paradigm for MFS is the lactose permease (LacY) ofEscherichia coli, which couples the stoichiometric translocation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5bfd3f49328ba5085aa77f8b301e61b
https://doi.org/10.1155/2014/523591
https://doi.org/10.1155/2014/523591