Zobrazeno 1 - 10
of 72
pro vyhledávání: '"M Gosden"'
Autor:
Lea Nussbaum, Arun Shivalingam, Jim R. Hughes, Tom Brown, Damien J. Downes, Nigel A. Roberts, Ron Schwessinger, James O.J. Davies, M Gosden, Jelena Telenius, Afaf H. El-Sagheer, Sara De Ornellas, A. Marieke Oudelaar, Martin J. Sergeant, Chris Eijsbouts, Veronica J. Buckle, Jon Kerry, Stephanie J Carpenter, Robert A. Beagrie
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chromosome conformation capture (3C) provides an adaptable tool for studying diverse biological questions. Current 3C methods generally provide either low-resolution interaction profiles across the entire genome, or high-resolution interaction profil
Autor:
Robert A. Beagrie, M Gosden, Danuta M. Jeziorska, Helena Francis, Christian Babbs, Douglas R. Higgs, Mira T. Kassouf, Andrew King, C L Harrold, Joseph Blayney
Mouse embryonic stem cells (mESCs) can be manipulatedin vitroto recapitulate the process of erythropoiesis, during which multipotent cells undergo lineage specification, differentiation and maturation to produce erythroid cells. Although useful for i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96ada153d435a54cf92aa6dce6bd412
https://doi.org/10.1101/2020.11.10.376749
https://doi.org/10.1101/2020.11.10.376749
Autor:
Ron Schwessinger, N Roy, Anna M. Rose, Chris Fisher, Raffaele Renella, Jill M. Brown, Kate Ryan, Jim R. Hughes, Veronica J. Buckle, Damien J. Downes, Quentin A. Hill, David J. P. Ferguson, Errin Johnson, Douglas R. Higgs, Aude-Anais Olijnik, M Gosden, Steven Okoli, Robert A. Beagrie, Marjorie Brand, Caroline Scott, Christian Babbs
Publikováno v:
Haematologica
Haematologica, vol. 106, no. 11, pp. 2960-2970
Haematologica, vol. 106, no. 11, pp. 2960-2970
The investigation of inherited disorders of erythropoiesis has elucidated many of the principles underlying the production of normal red blood cells and how this is perturbed in human disease. Congenital dyserythropoietic anemia type 1 (CDA-I) is a r
Autor:
R Stolper, Jim R. Hughes, Chris Preece, Lars L. P. Hanssen, C L Harrold, Daniel Biggs, Jacqueline A. Sharpe, Doug Higgs, Damien J. Downes, Jelena Telenius, Samy Alghadban, Jacqueline A. Sloane-Stanley, Mira T. Kassouf, Benjamin Davies, M Gosden
Mammalian genomes are subdivided into large (50-2000 kb) regions of chromatin referred to as Topologically Associating Domains (TADs or sub-TADs). Chromatin within an individual TAD contacts itself more frequently than with regions in surrounding TAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0e4bd42e7a8fa789352e9da59e6b851
https://doi.org/10.1101/2020.07.01.182089
https://doi.org/10.1101/2020.07.01.182089
Autor:
Douglas R. Higgs, M Gosden, Robert A. Beagrie, Joana Carrelha, Veronica J. Buckle, A M Oudelaar, E Georgiades, Tom Brown, Arun Shivalingam, Jon Kerry, Afaf H. El-Sagheer, S de Ornellas, Daniel Hidalgo, Merav Socolovsky, Jim R. Hughes, Jelena Telenius
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mammalian gene expression patterns are controlled by regulatory elements, which interact within topologically associating domains (TADs). The relationship between activation of regulatory elements, formation of structural chromatin interactions and g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2b6bcfde7437b3622d09156810c1ab
https://hdl.handle.net/21.11116/0000-0007-5BD4-421.11116/0000-0007-5BDC-C
https://hdl.handle.net/21.11116/0000-0007-5BD4-421.11116/0000-0007-5BDC-C
Autor:
Ron Schwessinger, Veronica J. Buckle, Lea Nussbaum, M Gosden, James O.J. Davies, Afaf H. El-Sagheer, Jon Kerry, Jim R. Hughes, Jelena Telenius, Martin J. Sergeant, Stephanie J Carpenter, A. Marieke Oudelaar, Tom Brown, Chris Eijsbouts, Nigel A. Roberts, Arun Shivalingam, Sara De Ornellas, Damien J. Downes
Chromosome conformation capture (3C) provides an adaptable tool for studying diverse biological questions. Current 3C methods provide either low-resolution interaction profiles across the entire genome, or high-resolution interaction profiles at up t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c015df218a78e48a24ed6944befd07
https://doi.org/10.1101/2020.03.02.953745
https://doi.org/10.1101/2020.03.02.953745
Autor:
Ron Schwessinger, A M Oudelaar, Yee Whye Teh, R C Brown, Jelena Telenius, Jim R. Hughes, Damien J. Downes, Gerton Lunter, M Gosden
Publikováno v:
Nature methods
Predicting the impact of noncoding genetic variation requires interpreting it in the context of three-dimensional genome architecture. We have developed deepC, a transfer-learning-based deep neural network that accurately predicts genome folding from
Autor:
Alix Bee, Daniel Brewer, Carol Beesley, Andrew Dodson, Shiva Forootan, Timothy Dickinson, Patricia Gerard, Brian Lane, Sheng Yao, Colin S Cooper, Mustafa B A Djamgoz, Christine M Gosden, Youqiang Ke, Christopher S Foster
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22672 (2011)
We provide novel functional data that posttranscriptional silencing of gene RPL19 using RNAi not only abrogates the malignant phenotype of PC-3M prostate cancer cells but is selective with respect to transcription and translation of other genes. Redu
Externí odkaz:
https://doaj.org/article/25562c9e84f341729fae58538863a1cf
Autor:
A. Marieke Oudelaar, Jacqueline A. Sharpe, Mira T. Kassouf, Douglas R. Higgs, Lars L. P. Hanssen, Chris Preece, Benjamin Davies, Jacqueline A. Sloane-Stanley, Damien J. Downes, M Gosden, Daniel Biggs, Jim R. Hughes
Publikováno v:
Nature cell biology
The genome is organized via CTCF–cohesin-binding sites, which partition chromosomes into 1–5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, con
Autor:
Y Bozhilov, M Gosden, Calliope A. Dendrou, Ryo Kurita, Damien J. Downes, Lea Nussbaum, Maria C. Suciu, Chris Fisher, Ron Schwessinger, Yusuke Nakamura, Veronica J. Buckle, Jim R. Hughes, Jon Kerry, S J Hill, Jill Davies, Davies Joj., Jelena Telenius, Larke Msc., P P Hirschfeld, A. Marieke Oudelaar, Stephen S. Taylor, Andrew J. King, R C Brown, John A. Todd, Gerton Lunter, C Eijsbouts, Caroline Scott, Inshaw Jrj., Simon J. McGowan, Douglas R. Higgs, Philip Hublitz, Antony J. Cutler
Genome-wide association studies (GWAS) have identified over 150,000 links between common genetic variants and human traits or complex diseases. Over 80% of these associations map to polymorphisms in non-coding DNA. Therefore, the challenge is to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549ecaf1b8a1f4116b8339b56bce0fd9