Zobrazeno 1 - 10
of 56
pro vyhledávání: '"M Gonzalez-Zulueta"'
Publikováno v:
Neuroscience. 116(2)
The cyclic AMP response element binding protein (CREB) has major roles in mediating adaptive responses at glutamatergic synapses and in the neuroprotective effects of neurotrophins. CREB has been implicated as a potential mediator of antidepressant a
Publikováno v:
Journal of neurochemistry. 76(5)
One approach to studying the functional role of individual NMDA receptor subunits involves the reduction in the abundance of the protein subunit in neurons. We have pursued a strategy to achieve this goal that involves the use of a small guide RNA wh
Publikováno v:
Progress in brain research. 118
Neuronal nitric oxide synthase (nNOS) participate in a variety of physiologic and pathologic processes in the nervous system. nNOS was originally felt to be a constitutively expressed enzyme, but recent observations suggest that its levels are dynami
Autor:
J M, Van Tornout, C H, Spruck, A, Shibata, C, Schmutte, M, Gonzalez-Zulueta, P W, Nichols, P T, Chandrasoma, M C, Yu, P A, Jones
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 6(7)
Mutatins of the p53 tumor suppressor gene are rare in nasopharyngeal carcinoma (NPC) patients who reside in high-risk areas, such as Southeastern China. Among this high-risk group, a pre-existing infection with the EBV and consumption of Cantonese sa
Autor:
A R, Simoneau, C H, Spruck, M, Gonzalez-Zulueta, M L, Gonzalgo, M F, Chan, Y C, Tsai, M, Dean, K, Steven, T, Horn, P A, Jones
Publikováno v:
Cancer research. 56(21)
The most common genetic alteration identified to date in bladder cancer is loss of heterozygosity (LOH) of chromosome 9, suggesting the presence of possible tumor suppressor genes on this chromosome. We attempted to map the location of these genes by
Autor:
M, Gonzalez-Zulueta, C M, Bender, A S, Yang, T, Nguyen, R W, Beart, J M, Van Tornout, P A, Jones
Publikováno v:
Cancer research. 55(20)
Loss of heterozygosity on 9p21, where the p16/CDKN2 tumor suppressor and the p15INK4B cell cycle regulator genes are located, is a common genetic alteration in bladder cancer. However, it has been difficult to demonstrate homozygous deletions and int
Autor:
C H, Spruck, P F, Ohneseit, M, Gonzalez-Zulueta, D, Esrig, N, Miyao, Y C, Tsai, S P, Lerner, C, Schmütte, A S, Yang, R, Cote
Publikováno v:
Cancer research. 54(3)
Noninvasive transitional cell carcinomas of the bladder can have two distinct morphologies suggesting they contain different genetic alterations. Papillary transitional cell carcinomas (T(a) tumors) are often multifocal and only occasionally progress
Autor:
M, Gonzalez-Zulueta, J M, Ruppert, K, Tokino, Y C, Tsai, C H, Spruck, N, Miyao, P W, Nichols, G G, Hermann, T, Horn, K, Steven
Publikováno v:
Cancer research. 53(23)
Somatic instability at microsatellite repeats was detected in 6 of 200 transitional cell carcinomas of the bladder. Instabilities were apparent as changes in (GT)n repeat lengths on human chromosome 9 for four tumors and as alterations in a (CAG)n re
Autor:
N, Miyao, Y C, Tsai, S P, Lerner, A F, Olumi, C H, Spruck, M, Gonzalez-Zulueta, P W, Nichols, D G, Skinner, P A, Jones
Publikováno v:
Cancer research. 53(17)
The tumors of 20 patients with multifocal primary transitional cell carcinoma of the bladder or lymph node metastases were examined for molecular genetic defects which we have previously found to be present in50% of invasive tumors. These included lo
Autor:
C H, Spruck, Y C, Tsai, D P, Huang, A S, Yang, W M, Rideout, M, Gonzalez-Zulueta, P, Choi, K W, Lo, M C, Yu, P A, Jones
Publikováno v:
Cancer research. 52(17)
Alterations in the p53 tumor suppressor gene and Epstein-Barr virus status were investigated in 15 nasopharyngeal carcinoma (NPC) biopsies, 4 xenografts, and 2 cell lines from the Cantonese region of southern China. One other established NPC cell lin