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POS0417 EXOGENOUS CXCL5 RESTORES ENDOGENOUS BLOOD-TISSUE CHEMOKINE GRADIENT TO IMPROVE SURVIVAL IN MURINE LUPUS

Autor: A. H. L. Loh, M. G. K. Tan, K. H. Lim, A. Low, William Hwang, X. Fan, A. Cheung, Julian Thumboo, S. Li, F. Lim, C. T. Ng, D. Guo, J. C. Tan, A. Law, S. L. Kong, Z. Y. Poon, J. Chen

Publikováno v: Annals of the Rheumatic Diseases. 80:437.2-438

Background:Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease that is potentially fatal. There is an unmet need to improve current therapies. In patients with SLE, we observed that serum CXCL5 levels were significantly lower than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fd7fc4d68f0defda08c7b2bef901cea
https://doi.org/10.1136/annrheumdis-2021-eular.2262

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Demonstration of mixed properties of RU486 in progesterone receptor (PR)-transfected MDA-MB-231 cells: a model for studying the functions of progesterone analogues

Autor: E H Ng, V C-L Lin, E H-L Ng, M G-K Tan, Swee Eng Aw

Publikováno v: British Journal of Cancer

Progesterone antagonist RU486 (mifepristone) has been implicated for many anti-neoplastic and obstetrical applications. But the compound has demonstrated undesired agonist-like effect depending on cell, tissue and species studied. Using PR-transfecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f78b0dffd72c61f883da89243fc24d
https://pubmed.ncbi.nlm.nih.gov/11747343

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