Výsledky vyhledávání - "M G Grütter"

Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides

Autor: C, Ciatto, A C, Tissot, M, Tschopp, G, Capitani, F, Pecorari, A, Plückthun, M G, Grütter

Publikováno v: Journal of molecular biology. 312(5)

Class I major histocompatibility complex (MHC) molecules, which display intracellularly processed peptides on the cell surface for scanning by T-cell receptors (TCRs), are extraordinarily polymorphic. MHC polymorphism is believed to result from natur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1829fd5af6f93f2fbc92882c06263a9a
https://pubmed.ncbi.nlm.nih.gov/11580250

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Structure of the soluble domain of a membrane-anchored thioredoxin-like protein from Bradyrhizobium japonicum reveals unusual properties

Autor: G, Capitani, R, Rossmann, D F, Sargent, M G, Grütter, T J, Richmond, H, Hennecke

Publikováno v: Journal of molecular biology. 311(5)

TlpA is an unusual thioredoxin-like protein present in the nitrogen-fixing soil bacterium Bradyrhizobium japonicum. A hydrophobic N-terminal transmembrane domain anchors it to the cytoplasmic membrane, whereby the hydrophilic thioredoxin domain becom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::016b724d5edcc801bded724dd87e3913
https://pubmed.ncbi.nlm.nih.gov/11531338

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Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex

Autor: H, Blanchard, M, Donepudi, M, Tschopp, L, Kodandapani, J C, Wu, M G, Grütter

Publikováno v: Journal of molecular biology. 302(1)

Caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target. Caspases are cysteine proteases that are specific for substrates with an aspartic acid residue at the P(1) position

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a353e04ce38bce640f50ccea8d2589ca
https://pubmed.ncbi.nlm.nih.gov/10964557

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The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase

Autor: Philippe Chemla, M Girardet, Raymonde Fonne-Pfister, R B Honzatko, E Ward, H J Fromm, K E Kreuz, M G Grütter, Sandra W. Cowan-Jacob, H P Schär

(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544a5e137ca20e33deac46eeb62b3718
https://europepmc.org/articles/PMC38445/

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Active site binding loop stabilization in the subtilisin inhibitor eglin c: structural and functional studies on specifically designed mutants in complex with subtilisin and the uncomplexed inhibitor

Autor: K, Hipler, J P, Priestle, J, Rahuel, M G, Grütter

Publikováno v: Advances in experimental medicine and biology. 379

As known from the x-ray crystal structure in complex with a proteinase and from NMR studies, the serine proteinase inhibitor eglin c has a wedge-like shape with a hydrophobic core and a solvent exposed active site binding loop which is stabilized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::606efbfe368377196eed1d31f83eaeb5
https://pubmed.ncbi.nlm.nih.gov/8796309

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Refined crystal structure of human transforming growth factor beta 2 at 1.95 A resolution

Autor: M P, Schlunegger, M G, Grütter

Publikováno v: Journal of molecular biology. 231(2)

Transforming growth factor beta 2 (TGF-beta 2), a homodimeric protein, is a member of a family of structurally related polypeptides that regulate various growth and differentiation processes in many cell types. The crystal structure of recombinant hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ca5b568f948118493b176310033a65f
https://pubmed.ncbi.nlm.nih.gov/8510156

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Synovial type (group II) phospholipase A2 in cartilage

Autor: T J, Nevalainen, F, Märki, P T, Kortesuo, M G, Grütter, S, Di Marco, A, Schmitz

Publikováno v: The Journal of rheumatology. 20(2)

Phospholipase A2 (PLA2) was produced in E. coli by a recombinant technique using a synthetic gene coding for PLA2 found in synovial fluid (SF) of patients suffering from rheumatoid arthritis (RA). Polyclonal antibodies were produced against the recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::446da17641632249e7f18fbb244f455f
https://pubmed.ncbi.nlm.nih.gov/8474071

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Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes

Autor: D W, Heinz, J P, Priestle, J, Rahuel, K S, Wilson, M G, Grütter

Publikováno v: Journal of molecular biology. 217(2)

The crystal structures of the complexes formed between subtilisin Novo and three inhibitors, eglin c, Arg45-eglin c and Lys53-eglin c have been determined using molecular replacement and difference Fourier techniques and refined at 2.4 A, 2.1 A, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0c8ea8b1ca94818c81d6ace83ef6e9d
https://pubmed.ncbi.nlm.nih.gov/1992167

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Thermodynamic stability and point mutations of bacteriophage T4 lysozyme

Autor: Richard Hawkes, M. G. Grütter, John A. Schellman

Publikováno v: Journal of Molecular Biology. 175:195-212

The thermodynamics of melting of bacteriophage T4 lysozyme and four of its mutants have been measured by van't Hoff methods. The effect of pH has been explored and utilized to obtain the dependence of the enthalpy on temperature as suggested by Priva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64585dc2d19ff97e6ca6006094873c4b
https://doi.org/10.1016/0022-2836(84)90474-1

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