Zobrazeno 1 - 10
of 59
pro vyhledávání: '"M G, Smits"'
Autor:
Collin Homer-Bouthiette, Yang Zhao, Lauren B. Shunkwiler, Benjamine Van Peel, Elizabeth Garrett-Mayer, Rachael C. Baird, Anna I. Rissman, Stephen T. Guest, Stephen P. Ethier, Manorama C. John, Patricia A. Powers, Jill D. Haag, Michael N. Gould, Bart M. G. Smits
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background The gene desert on human chromosomal band 8q24 harbors multiple genetic variants associated with common cancers, including breast cancer. The locus, including the gene desert and its flanking genes, MYC, PVT1 and FAM84B, is also f
Externí odkaz:
https://doaj.org/article/b21bf55990924a71bc092663c943b4b4
Autor:
Lina Ding, Lauren B Shunkwiler, Nicholas W Harper, Yang Zhao, Kunihiko Hinohara, Sung Jin Huh, Muhammad B Ekram, Jan Guz, Michael J Kern, Alexander Awgulewitsch, James D Shull, Bart M G Smits, Kornelia Polyak
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008002 (2019)
Mammary epithelial progenitors are the normal cell-of-origin of breast cancer. We previously defined a population of p27+ quiescent hormone-responsive progenitor cells in the normal human breast whose frequency associates with breast cancer risk. Her
Externí odkaz:
https://doaj.org/article/d67d87ad06f84ad6b3000b0206d5eefa
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006261 (2016)
In understanding the etiology of breast cancer, the contributions of both genetic and environmental risk factors are further complicated by the impact of breast developmental stage. Specifically, the time period ranging from childhood to young adulth
Externí odkaz:
https://doaj.org/article/b64995bcadd44b8d9ff707c6649290d9
Autor:
Deepak Sharma, Mark R. Eichelberg, Jill D. Haag, Amanda L. Meilahn, Matthew J. Muelbl, Kathy Schell, Bart M. G. Smits, Michael N. Gould
Publikováno v:
BioTechniques, Vol 53, Iss 1, Pp 57-60 (2012)
Here we introduce a modified antibody staining method that uses up to 80% less antibody for flow cytometry. We demonstrate this method for the detection of antigens expressed at high, moderate, or low levels in mouse and rat lymphocytes as well as mo
Externí odkaz:
https://doaj.org/article/d68ec6f983794c46a5f354919a010241
Autor:
Bart M G Smits, Jill D Haag, Anna I Rissman, Deepak Sharma, Ann Tran, Alexi A Schoenborn, Rachael C Baird, Dan S Peiffer, David Q Leinweber, Matthew J Muelbl, Amanda L Meilahn, Mark R Eichelberg, Ning Leng, Christina Kendziorski, Manorama C John, Patricia A Powers, Caroline M Alexander, Michael N Gould
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003549 (2013)
Genome-wide association studies have revealed that many low-penetrance breast cancer susceptibility loci are located in non-protein coding genomic regions; however, few have been characterized. In a comparative genetics approach to model such loci in
Externí odkaz:
https://doaj.org/article/c1b2aaae8803497caec92d2d74a0a3cb
Publikováno v:
Journal of Visualized Experiments.
As early as the 1970s, researchers have successfully transplanted mammary epithelial cells into the interscapular white fat pad of rats. Grafting mammary epithelium using transplantation techniques takes advantage of the hormonal environment provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb522b48fde9c9f168c053214aeb75aa
https://doi.org/10.3791/60401
https://doi.org/10.3791/60401
Autor:
Nadine Held, Bart M G Smits, Roland Gockeln, Stephanie Schubert, Heike Nave, Emily Northrup, Edwin Cuppen, Hans J Hedrich, Dirk Wedekind
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e15669 (2011)
The LEW/Ztm-ci2 rat is an animal model for syndromal deafness that arose from a spontaneous mutation. Homozygous animals show locomotor abnormalities like lateralized circling behavior. Additionally, an impaired vision can be observed in some animals
Externí odkaz:
https://doaj.org/article/cd89b2bf9191452eaeacab3a28608780
Autor:
Deepak Sharma, Bart M G Smits, Mark R Eichelberg, Amanda L Meilahn, Matthew J Muelbl, Jill D Haag, Michael N Gould
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26145 (2011)
Rat mammary carcinogenesis models have been used extensively to study breast cancer initiation, progression, prevention, and intervention. Nevertheless, quantitative molecular data on epithelial cell differentiation in mammary glands of untreated and
Externí odkaz:
https://doaj.org/article/51aff2eb937f4a3a9b2c9adfd6f67d68
Publikováno v:
PLoS Genetics, Vol 2, Iss 7, p e121 (2006)
Genetic variation in genomes is organized in haplotype blocks, and species-specific block structure is defined by differential contribution of population history effects in combination with mutation and recombination events. Haplotype maps characteri
Externí odkaz:
https://doaj.org/article/adf596bca2e04eb8bb044daa4420a1b4
Autor:
Kornelia Polyak, Alexander Awgulewitsch, Lina Ding, Yang Zhao, Muhammad B. Ekram, Lauren B. Shunkwiler, Jan Guz, James D. Shull, Michael J. Kern, Nicholas W. Harper, Bart M. G. Smits, Kunihiko Hinohara, Sung Jin Huh
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008002 (2019)
PLoS Genetics
PLoS Genetics
Mammary epithelial progenitors are the normal cell-of-origin of breast cancer. We previously defined a population of p27+ quiescent hormone-responsive progenitor cells in the normal human breast whose frequency associates with breast cancer risk. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2cf017fed4451396bbe318d0bf1d56
http://europepmc.org/articles/PMC6443185?pdf=render
http://europepmc.org/articles/PMC6443185?pdf=render