Synthesis, antiplatelet activity and comparative molecular field analysis of substituted 2-amino-4 H -pyrido[1,2- a ]pyrimidin-4-ones, their congeners and isosteric analogues

Autor: G, Roma, N, Cinone, M, Di Braccio, G, Grossi, G, Leoncini, M G, Signorello, A, Carotti, A, Carott

Publikováno v: Bioorganic & Medicinal Chemistry. 8:751-768

2-(1-Piperazinyl)-4H-pyrido[1,2-a]pyrimidin-4-one Chart 5 , Scheme 2 Download : Download high-res image (50KB) Download : Download full-size image Chart 5 . Download : Download high-res image (186KB) Download : Download full-size image Scheme 2 . is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8541dab7a127bc40351ffd3fc663209f
https://doi.org/10.1016/s0968-0896(00)00010-9

Effect of homocysteine on arachidonic acid release in human platelets

Autor: M G, Signorello, R, Pascale, G, Leoncini

Publikováno v: European journal of clinical investigation. 32(4)

It has been suggested that homocysteine is implicated in the risk of atherosclerosis and thrombosis. The pathogenic mechanism has not been clarified, but oxygen-free species produced by the homocysteine metabolism and auto-oxidation could have a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e4e8bb123c3010ca9253a695030ab55
https://pubmed.ncbi.nlm.nih.gov/11952814

Insights into the Pharmacological Activity of the Imidazo-Pyrazole Scaffold.

Autor: Spallarossa A; Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132, Genova, Italy., Rapetti F; Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132, Genova, Italy., Signorello MG; Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132, Genova, Italy., Rosano C; IRCCS Ospedale Policlinico San Martino Unit Proteomics and Mass Spectrometry, L.go. R. Benzi, 10, 16132, Genova, Italy., Iervasi E; IRCCS Ospedale Policlinico San Martino Unit Proteomics and Mass Spectrometry, L.go. R. Benzi, 10, 16132, Genova, Italy., Ponassi M; IRCCS Ospedale Policlinico San Martino Unit Proteomics and Mass Spectrometry, L.go. R. Benzi, 10, 16132, Genova, Italy., Brullo C; Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132, Genova, Italy.

Publikováno v: ChemMedChem [ChemMedChem] 2023 Sep 01; Vol. 18 (17), pp. e202300252. Date of Electronic Publication: 2023 Jul 12.

Biologically active thio‐pyrimidinones from base‐catalyzed thiol‐ene coupling with maleimides.

Autor: Feitosa, Sidney Gustavo Diniz¹ (AUTHOR), Maciel, Larissa Gonçalves² (AUTHOR), dos Anjos, Janaína Versiani¹ (AUTHOR) janaina.anjos@ufpe.br

Publikováno v: Journal of Heterocyclic Chemistry. Aug2022, Vol. 59 Issue 8, p1385-1396. 12p.

Measuring Heterogeneous Preferences for Adaptation Strategies in Response to Sea Level Rise: Evidence from Miami-Dade County.

Autor: Chen, Xuqi (AUTHOR) xchen88@utk.edu, Gao, Zhifeng (AUTHOR) zfgao@ufl.edu, Bi, Xiang (AUTHOR) bix@gao.gov

Publikováno v: Land Economics. Feb2023, Vol. 99 Issue 1, p1-26. 26p.