Zobrazeno 1 - 10
of 57
pro vyhledávání: '"M G, Rosenblum"'
Publikováno v:
Journal of Interferon & Cytokine Research. 15:547-555
The plant toxin gelonin is an extremely potent inhibitor of protein synthesis, similar in action to ricin. The mature protein primary sequence was obtained using conventional sequencing techniques. Gelonin was found to be composed of 258 amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7ea50f0a3138accad90429ab59be93
https://doi.org/10.1089/jir.1995.15.547
https://doi.org/10.1089/jir.1995.15.547
Publikováno v:
International journal of cancer. 88(2)
Over-expression of the proto-oncogene HER2/neu in breast cancer and certain other tumors appears to be a central mechanism that may be partly responsible for cellular progression of the neoplastic phenotype. Transfection of mammalian cells and over-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f02913a0d4e362684f039071e5495f6
https://pubmed.ncbi.nlm.nih.gov/11004679
https://pubmed.ncbi.nlm.nih.gov/11004679
Autor:
M G, Rosenblum, C F, Verschraegen, J L, Murray, A P, Kudelka, J, Gano, L, Cheung, J J, Kavanagh
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(5)
The tumor-associated glycoprotein 72 (TAG-72) antigen is present on a high percentage of tumor types including ovarian carcinomas. Antibody B72.3 is a murine monoclonal recognizing the surface domain of the TAG-72 antigen and has been widely used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbabfb097347f8e84659bcf2059152cf
https://pubmed.ncbi.nlm.nih.gov/10353726
https://pubmed.ncbi.nlm.nih.gov/10353726
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4)
TAB-250 and BACH-250 are murine and human chimeric antibodies directed at the extracellular domain of the gp185c-erb-2 (HER2/neu) growth factor receptor overexpressed in a variety of tumor types, including ovarian and breast carcinoma. The ribosome-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f6355af1ae70ad110808a8aa4013fac
https://pubmed.ncbi.nlm.nih.gov/10213223
https://pubmed.ncbi.nlm.nih.gov/10213223
Autor:
D J, Macey, E J, Grant, L, Kasi, M G, Rosenblum, H Z, Zhang, R L, Katz, P T, Rieger, D, LeBherz, M, South, J W, Greiner, J, Schlom, D A, Podoloff, J L, Murray
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(9)
Preclinical studies have demonstrated that recombinant IFN-alpha (rIFN-alpha) can enhance the tumor associated glycoprotein 72 (TAG-72) on tumors. To determine whether rIFN-alpha could enhance TAG-72 expression in vivo in patients, 15 women with brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fc19248b618680ff70d44ff1ed2ebcd
https://pubmed.ncbi.nlm.nih.gov/9815842
https://pubmed.ncbi.nlm.nih.gov/9815842
Autor:
L C, Pagliaro, B, Liu, R, Munker, M, Andreeff, E J, Freireich, D A, Scheinberg, M G, Rosenblum
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(8)
The recently characterized immunotoxin HuM195-gelonin consists of a humanized anti-CD33 monoclonal antibody conjugated to the single-chain plant toxin gelonin. Binding of the immunotoxin to hematopoietic cells that express the CD33 differentiation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b5b9e3fc26e90bb8da92b6fbf37708c
https://pubmed.ncbi.nlm.nih.gov/9717827
https://pubmed.ncbi.nlm.nih.gov/9717827
Publikováno v:
Leukemia. 10(2)
A leukemia-selective immunotoxin was constructed by linking recombinant gelonin (rGel), a single chain ribosome inhibitory protein, to recombinant humanized M195 antibody (HuM195), which recognizes the cell-surface protein designated CD33. CD33 is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80ef6be8bcd6aae11fb6777a31eb7beb
https://pubmed.ncbi.nlm.nih.gov/8637241
https://pubmed.ncbi.nlm.nih.gov/8637241
Autor:
J L, Murray, D J, Macey, E J, Grant, M G, Rosenblum, L P, Kasi, H Z, Zhang, R L, Katz, P T, Riger, D, LeBherz, V, Bhadkamkar
Publikováno v:
Cancer research. 55
The IFNs, alpha and gamma, have been shown to enhance the tumor-associated glycoprotein (TAG-72) on adenocarcinoma cells in vitro and in mice with human breast cancer xenografts, resulting in improved targeting of monoclonal antibody CC49. To determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fabd687a832e57baa664b2e84a01ca1
https://pubmed.ncbi.nlm.nih.gov/7493372
https://pubmed.ncbi.nlm.nih.gov/7493372
Publikováno v:
Journal of pharmaceutical sciences. 83(7)
Previously, we have shown that liposomal amphotericin B (L-AmpB) composed of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) was less nephrotoxic but equally as effective as Fungizone, which consists of amphotericin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b164a3fb4258a09e803487883bf73b9
https://pubmed.ncbi.nlm.nih.gov/7965656
https://pubmed.ncbi.nlm.nih.gov/7965656
Autor:
J L, Murray, D J, Macey, L P, Kasi, P, Rieger, J, Cunningham, V, Bhadkamkar, H Z, Zhang, J, Schlom, M G, Rosenblum, D A, Podoloff
Publikováno v:
Cancer. 73
Radiolabeled CC49, a second generation high affinity monoclonal antibody (MoAb) reactive with tumor-associated glycoprotein 72 (TAG72) has undergone previous Phase I testing in patients with colon cancer. Based on this report, the authors treated 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::153342a8758ebbc621a91d71ff6e7a02
https://pubmed.ncbi.nlm.nih.gov/8306248
https://pubmed.ncbi.nlm.nih.gov/8306248