Výsledky vyhledávání - "M G, Grütter"

Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides

Autor: C, Ciatto, A C, Tissot, M, Tschopp, G, Capitani, F, Pecorari, A, Plückthun, M G, Grütter

Publikováno v: Journal of molecular biology. 312(5)

Class I major histocompatibility complex (MHC) molecules, which display intracellularly processed peptides on the cell surface for scanning by T-cell receptors (TCRs), are extraordinarily polymorphic. MHC polymorphism is believed to result from natur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1829fd5af6f93f2fbc92882c06263a9a
https://pubmed.ncbi.nlm.nih.gov/11580250

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Structure of the soluble domain of a membrane-anchored thioredoxin-like protein from Bradyrhizobium japonicum reveals unusual properties

Autor: G, Capitani, R, Rossmann, D F, Sargent, M G, Grütter, T J, Richmond, H, Hennecke

Publikováno v: Journal of molecular biology. 311(5)

TlpA is an unusual thioredoxin-like protein present in the nitrogen-fixing soil bacterium Bradyrhizobium japonicum. A hydrophobic N-terminal transmembrane domain anchors it to the cytoplasmic membrane, whereby the hydrophilic thioredoxin domain becom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::016b724d5edcc801bded724dd87e3913
https://pubmed.ncbi.nlm.nih.gov/11531338

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Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex

Autor: H, Blanchard, M, Donepudi, M, Tschopp, L, Kodandapani, J C, Wu, M G, Grütter

Publikováno v: Journal of molecular biology. 302(1)

Caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target. Caspases are cysteine proteases that are specific for substrates with an aspartic acid residue at the P(1) position

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a353e04ce38bce640f50ccea8d2589ca
https://pubmed.ncbi.nlm.nih.gov/10964557

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Akademický článek

Advances and Prospects in Integrated Nano-oncology.

Autor: Jinlei Jiang^1,2, Xinyuan Cui³, Yixin Huang^1,2, Dongmei Yan⁴, Bensong Wang¹, Ziyang Yang^1,2, Mingrui Chen¹, Junhao Wang¹, Yuna Zhang¹, Guan Liu¹, Cheng Zhou^1,2, Shengsheng Cui^1,2, Jian Ni^1,2, Fuhua Yang³ yfh11655@rjh.com.cn, Daxiang Cui^1,2,5 dxcui@sjtu.edu.cn

Publikováno v: Nano Biomedicine & Engineering. Jun2024, Vol. 16 Issue 2, p152-187. 36p.

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The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase

Autor: Philippe Chemla, M Girardet, Raymonde Fonne-Pfister, R B Honzatko, E Ward, H J Fromm, K E Kreuz, M G Grütter, Sandra W. Cowan-Jacob, H P Schär

(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544a5e137ca20e33deac46eeb62b3718
https://europepmc.org/articles/PMC38445/

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Active site binding loop stabilization in the subtilisin inhibitor eglin c: structural and functional studies on specifically designed mutants in complex with subtilisin and the uncomplexed inhibitor

Autor: K, Hipler, J P, Priestle, J, Rahuel, M G, Grütter

Publikováno v: Advances in experimental medicine and biology. 379

As known from the x-ray crystal structure in complex with a proteinase and from NMR studies, the serine proteinase inhibitor eglin c has a wedge-like shape with a hydrophobic core and a solvent exposed active site binding loop which is stabilized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::606efbfe368377196eed1d31f83eaeb5
https://pubmed.ncbi.nlm.nih.gov/8796309

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Refined crystal structure of human transforming growth factor beta 2 at 1.95 A resolution

Autor: M P, Schlunegger, M G, Grütter

Publikováno v: Journal of molecular biology. 231(2)

Transforming growth factor beta 2 (TGF-beta 2), a homodimeric protein, is a member of a family of structurally related polypeptides that regulate various growth and differentiation processes in many cell types. The crystal structure of recombinant hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ca5b568f948118493b176310033a65f
https://pubmed.ncbi.nlm.nih.gov/8510156

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Synovial type (group II) phospholipase A2 in cartilage

Autor: T J, Nevalainen, F, Märki, P T, Kortesuo, M G, Grütter, S, Di Marco, A, Schmitz

Publikováno v: The Journal of rheumatology. 20(2)

Phospholipase A2 (PLA2) was produced in E. coli by a recombinant technique using a synthetic gene coding for PLA2 found in synovial fluid (SF) of patients suffering from rheumatoid arthritis (RA). Polyclonal antibodies were produced against the recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::446da17641632249e7f18fbb244f455f
https://pubmed.ncbi.nlm.nih.gov/8474071

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