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Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs

Autor: Stephen B. Liggett, Hitoshi Kurose, M G Eason, B D Holt, John R. Raymond

Publikováno v: Journal of Biological Chemistry. 267:15795-15801

Coupling of the three alpha 2-adrenergic receptor (alpha 2AR) subtypes to Gi and Gs was studied in membranes from transfected CHO cells. We observed that in the presence of low concentrations of the alpha 2AR agonist UK-14304, alpha 2C10 mediated inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36e899b56b6204c7a5e238d80260db40
https://doi.org/10.1016/s0021-9258(19)49605-1

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Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains

Autor: M G, Eason, S B, Liggett

Publikováno v: The Journal of biological chemistry. 271(22)

We have investigated potential Gi and Gs coupling domains within the intracellular regions of the alpha2AAR subtype using a series of nine chimeric mutations. The second intracellular loop (ICL2, amino acids 133-149) and the amino- and carboxyl-termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05643d624e40ad63388b1cad57cd90d1
https://pubmed.ncbi.nlm.nih.gov/8662784

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Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling

Autor: M G, Eason, S B, Liggett

Publikováno v: The Journal of biological chemistry. 270(42)

alpha2-Adrenergic receptors (alpha 2AR) functionally couple not only to Gi but also to Gs. We investigated the amino-terminal portion of the third intracellular loop of the human alpha 2AAR (alpha 2C10) for potential Gs coupling domains using site-di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd1a434d88999bc547bfb5bec0f6f05c
https://pubmed.ncbi.nlm.nih.gov/7559592

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Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs

Autor: M G, Eason, M T, Jacinto, S B, Liggett

Publikováno v: Molecular pharmacology. 45(4)

Recently, we have demonstrated that alpha 2-adrenergic receptors (alpha 2AR) functionally couple not only to Gi but also to Gs. This alpha 2AR-Gs coupling was subtype selective, in that the degree of alpha 2AR-Gs (but not -Gi) coupling was different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b446c07ad28e7bbf4b05421a433d91a
https://pubmed.ncbi.nlm.nih.gov/7910371

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Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues

Autor: M G, Eason, S B, Liggett

Publikováno v: Molecular pharmacology. 44(1)

At present, molecular cloning and pharmacological studies have delineated three human alpha 2-adrenergic receptor (alpha 2AR) subtypes, alpha 2C10, alpha 2C4, and alpha 2C2. Assignment of the alpha 2AR subtypes to specific functions has been limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41e59508961aed3207bb23029bb2c5b7
https://pubmed.ncbi.nlm.nih.gov/7688069

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Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2

Autor: M G, Eason, S B, Liggett

Publikováno v: The Journal of biological chemistry. 267(35)

We have recently shown that the alpha 2C10 adrenergic receptor (AR) undergoes short term agonist-promoted desensitization, mediated by phosphorylation of sites in the third intracellular loop. There is significant divergence in the third loop amino a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff46c2bd5a5be9cfe5af01e7a17ac10e
https://pubmed.ncbi.nlm.nih.gov/1334095

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Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs

Autor: M G, Eason, H, Kurose, B D, Holt, J R, Raymond, S B, Liggett

Publikováno v: The Journal of biological chemistry. 267(22)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ddc98c186d97e8108861609f28f8cee
https://pubmed.ncbi.nlm.nih.gov/1322406

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