Výsledky vyhledávání

'A system biology' approach to bioinformatics and functional genomics in complex human diseases: arthritis

Autor: M G, Attur, M N, Dave, K, Tsunoyama, M, Akamatsu, M, Kobori, J, Miki, S B, Abramson, M, Katoh, A R, Amin

Publikováno v: Current issues in molecular biology. 4(4)

Human and other annotated genome sequences have facilitated generation of vast amounts of correlative data, from human/animal genetics, normal and disease-affected tissues from complex diseases such as arthritis using gene/protein chips and SNP analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbb8c90aada41480e91582575626eb79
https://pubmed.ncbi.nlm.nih.gov/12432964

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Osteopontin: an intrinsic inhibitor of inflammation in cartilage

Autor: M G, Attur, M N, Dave, S, Stuchin, A J, Kowalski, G, Steiner, S B, Abramson, D T, Denhardt, A R, Amin

Publikováno v: Arthritis and rheumatism. 44(3)

To identify extracellular and intraarticular matrix components that are differentially expressed in normal and osteoarthritis (OA)-affected cartilage and to investigate their functions with respect to regulation of mediators of inflammation.Different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57d4014c72587d09474bafabc1c62e1f
https://pubmed.ncbi.nlm.nih.gov/11263772

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Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention

Autor: M G, Attur, M, Dave, C, Cipolletta, P, Kang, M B, Goldring, I R, Patel, S B, Abramson, A R, Amin

Publikováno v: The Journal of biological chemistry. 275(51)

Interleukin 1 (IL-1), produced by both synovial cells and chondrocytes, plays a pivotal role in the pathogenesis of cartilage destruction in osteoarthritis (OA). We examined the specific expression and function of IL-1 receptor family-related genes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14bb0bde7114b57e4b71d948d921c45d
https://pubmed.ncbi.nlm.nih.gov/11007768

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A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production

Autor: R N, Patel, M G, Attur, M N, Dave, I V, Patel, S A, Stuchin, S B, Abramson, A R, Amin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(6)

Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE2 production. In contrast, chemically modified tetracyclines (CMTs), such as CMT-3 and -8 (but not CMT-1, -2, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85578d89db69598f2e6d1d8467e62951
https://pubmed.ncbi.nlm.nih.gov/10477618

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Regulation of cytosolic COX-2 and prostaglandin E2 production by nitric oxide in activated murine macrophages

Autor: R, Patel, M G, Attur, M, Dave, S B, Abramson, A R, Amin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(7)

Murine macrophages (RAW 264.7) when stimulated with LPS show 90% distribution of cyclooxygenase-2 (COX-2) in the nuclear fraction and approximately 10% in the cytosolic fraction. Further analysis of this cytosolic fraction at 100,000 x g indicates th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8013849dc27ef03c6bbdbf1503d8b669
https://pubmed.ncbi.nlm.nih.gov/10201946

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Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide

Autor: M G, Attur, R N, Patel, P D, Patel, S B, Abramson, A R, Amin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(6)

Tetracyclines (doxycycline and minocycline) augmented (one- to twofold) the PGE2 production in human osteoarthritis-affected cartilage (in the presence or absence of cytokines and endotoxin) in ex vivo conditions. Similarly, bovine chondrocytes stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c04bf44c691b73e534201fccb5140dad
https://pubmed.ncbi.nlm.nih.gov/10092766

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TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha

Autor: I R, Patel, M G, Attur, R N, Patel, S A, Stuchin, R A, Abagyan, S B, Abramson, A R, Amin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(9)

A snake venom-like protease isolated by a differential display screen between normal and osteoarthritis (OA)-affected cartilage (designated as cSVP) has a cDNA sequence identical to TNF-alpha convertase enzyme (TACE). TACE shows the presence of an un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69ebc6707ed23275868553dadaa0126c
https://pubmed.ncbi.nlm.nih.gov/9574564

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Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8

Autor: M G, Attur, I R, Patel, R N, Patel, S B, Abramson, A R, Amin

Publikováno v: Proceedings of the Association of American Physicians. 110(1)

Interleukin-1 beta (IL-1 beta) plays a central role in the pathophysiology of cartilage damage and degradation in arthritis. In noninflammatory arthropathies such as osteoarthritis (OA), the synovial-derived IL-1 beta has been implicated in the disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56f9ec868c2dbbc2d48c8d2d8aa46947
https://pubmed.ncbi.nlm.nih.gov/9460084

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