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Akademický článek

The effects of cyanobacterial blooms on the immune system of Elliptio complanata in urban and agricultural areas in the Yamaska River watershed

Autor: F Gagné, M Gélinas, M Fortier, M Fournier

Publikováno v: Invertebrate Survival Journal, Vol 15, Iss 1 (2018)

The cumulative effects of cyanobacterial blooms at sites impacted by urban or agricultural activity, could be detrimental to local freshwater mussels. The purpose of this study was to examine and compare the resulting toxicity using an upstream–dow

Externí odkaz: https://doaj.org/article/33a29d72f9e64c9290d8f3bb852f099b

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Akademický článek

On the visual detection of non-natural records in streamflow time series: challenges and impacts

Publikováno v: Hydrology and Earth System Sciences, Vol 27, Pp 3375-3391 (2023)

Large datasets of long-term streamflow measurements are widely used to infer and model hydrological processes. However, streamflow measurements may suffer from what users can consider anomalies, i.e. non-natural records that may be erroneous streamfl

Externí odkaz: https://doaj.org/article/e97086dbc2be47ed969dc6a433972466

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Akademický článek

Effect of repeated seizures on spatial exploration and immediate early gene expression in the hippocampus and dentate gyrus

Autor: Alena Kalinina, Zakhar Krekhno, Janet Yee, Hugo Lehmann, Neil M. Fournier

Publikováno v: IBRO Neuroscience Reports, Vol 12, Iss , Pp 73-80 (2022)

Immediate early genes (IEGs) are coordinately activated in response to neuronal activity and can cause activation of secondary response genes that modulate synaptic plasticity and mediate long-lasting changes in behaviour. Excessive neuronal stimulat

Externí odkaz: https://doaj.org/article/ad02f4c432fe4b75b388e42140d98e9a

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Akademický článek

S295: CLINICAL RELEVANCE OF SPLEEN VOLUME AND PLATELET COUNT WITH BLEEDING EVENTS IN PATIENTS WITH ACID SPHINGOMYELINASE DEFICIENCY (ASMD)

Autor: M. Fournier, J. Msihid, A. Willemze, F. Laredo, R. Pulikottil-Jacob

Publikováno v: HemaSphere, Vol 6, Pp 196-197 (2022)

Externí odkaz: https://doaj.org/article/178e70e1b0ce466d8e9bccec2bfb2d84

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First (e,e) coincidence measurements on solvated sodium benzoate in water using a magnetic bottle time-of-flight spectrometer

Autor: L. Huart, M. Fournier, R. Dupuy, R. Vacheresse, M. Mailhiot, D. Cubaynes, D. Céolin, M. A. Hervé du Penhoat, J. P. Renault, J.-M. Guigner, A. Kumar, B. Lutet-Toti, J. Bozek, I. Ismail, L. Journel, P. Lablanquie, F. Penent, C. Nicolas, J. Palaudoux

Publikováno v: Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, 2022, ⟨10.1039/d2cp02982k⟩

Understanding the mechanisms of X-ray radiation damage in biological systems is of prime interest in medicine (radioprotection, X-ray therapy…). Study of low-energy rays, such as soft-X rays and light ions, points to attribute their lethal effect t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8755eab16c23629f1545196c64410a49
https://doi.org/10.1039/d2cp02982k

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Akademický článek

Chronic Jet Lag Simulation Decreases Hippocampal Neurogenesis and Enhances Depressive Behaviors and Cognitive Deficits in Adult Male Rats

Autor: Emily A. Horsey, Teresa Maletta, Holly Turner, Chantel Cole, Hugo Lehmann, Neil M. Fournier

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 13 (2020)

There is a long history that protracted periods of circadian disruption, such as through frequent transmeridian travel or rotating shift work, can have a significant impact on brain function and health. In addition, several studies have shown that ch

Externí odkaz: https://doaj.org/article/36ce5baded70424e98e1deede3756454

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Akademický článek

SNO KARST: A French Network of Observatories for the Multidisciplinary Study of Critical Zone Processes in Karst Watersheds and Aquifers

Autor: H. Jourde, N. Massei, N. Mazzilli, S. Binet, C. Batiot-Guilhe, D. Labat, M. Steinmann, V. Bailly-Comte, J.L. Seidel, B. Arfib, J.B. Charlier, V. Guinot, A. Jardani, M. Fournier, M. Aliouache, M. Babic, C. Bertrand, P. Brunet, J.F. Boyer, J.P. Bricquet, T. Camboulive, S.D. Carrière, H. Celle-Jeanton, K. Chalikakis, N. Chen, C. Cholet, V. Clauzon, L. Dal Soglio, C. Danquigny, C. Défargue, S. Denimal, C. Emblanch, F. Hernandez, M. Gillon, A. Gutierrez, L. Hidalgo Sanchez, M. Hery, N. Houillon, A. Johannet, J. Jouves, N. Jozja, B. Ladouche, V. Leonardi, G. Lorette, C. Loup, P. Marchand, V. de Montety, R. Muller, C. Ollivier, V. Sivelle, R. Lastennet, N. Lecoq, J. C. Maréchal, L. Perotin, J. Perrin, M.A. Petre, N. Peyraube, S. Pistre, V. Plagnes, A. Probst, J.L. Probst, R. Simler, V. Stefani, D. Valdes-Lao, S. Viseur, X. Wang

Publikováno v: Vadose Zone Journal, Vol 17, Iss 1 (2018)

Karst aquifers and watersheds represent a major source of drinking water around the world. They are also known as complex and often highly vulnerable hydrosystems due to strong surface–groundwater interactions. Improving the understanding of karst

Externí odkaz: https://doaj.org/article/8066576ac07142388f02fb28b19ca095

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Data from Expanding the Repertoire for 'Large Small Molecules': Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers

Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1

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Supplementary Data from Expanding the Repertoire for 'Large Small Molecules': Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers

1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290

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Akademický článek

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