Zobrazeno 1 - 10
of 608
pro vyhledávání: '"M Flint Beal"'
Autor:
Pablo Ranea‐Robles, Nathalie Launay, Montserrat Ruiz, Noel Ylagan Calingasan, Magali Dumont, Alba Naudí, Manuel Portero‐Otín, Reinald Pamplona, Isidre Ferrer, M Flint Beal, Stéphane Fourcade, Aurora Pujol
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 8, Pp 1-16 (2018)
Abstract The nuclear factor erythroid 2‐like 2 (NRF2) is the master regulator of endogenous antioxidant responses. Oxidative damage is a shared and early‐appearing feature in X‐linked adrenoleukodystrophy (X‐ALD) patients and the mouse model
Externí odkaz:
https://doaj.org/article/a7f9490313664689b1a646a1426eb0b8
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 597-610 (2009)
Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,21Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondria
Externí odkaz:
https://doaj.org/article/1af4ca5fd8ab49b58681c1b6bd15f3cf
Autor:
Keiichi Inoue, Joanne Rispoli, Lichuan Yang, David Macleod, M Flint Beal, Eric Klann, Asa Abeliovich
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003845 (2013)
Macroautophagy is a conserved mechanism for the bulk degradation of proteins and organelles. Pathological studies have implicated defective macroautophagy in neurodegeneration, but physiological functions of macroautophagy in adult neurons remain unc
Externí odkaz:
https://doaj.org/article/d9c55396f76c41fa8407c92d6fa4699f
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36191 (2012)
Parkinson's disease (PD) is a neurodegenerative disease in which the etiology of 90 percent of the patients is unknown. Pesticide exposure is a major risk factor for PD, and paraquat (PQ), pyridaben (PY) and maneb (MN) are amongst the most widely use
Externí odkaz:
https://doaj.org/article/8058b4cf9a8b49d3b84769b0aaf44b44
Autor:
David Ramonet, João Paulo L Daher, Brian M Lin, Klodjan Stafa, Jaekwang Kim, Rebecca Banerjee, Marie Westerlund, Olga Pletnikova, Liliane Glauser, Lichuan Yang, Ying Liu, Deborah A Swing, M Flint Beal, Juan C Troncoso, J Michael McCaffery, Nancy A Jenkins, Neal G Copeland, Dagmar Galter, Bobby Thomas, Michael K Lee, Ted M Dawson, Valina L Dawson, Darren J Moore
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18568 (2011)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemi
Externí odkaz:
https://doaj.org/article/01d6a4bc1a0c4047be5141533aeb099b
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15546 (2010)
Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown
Externí odkaz:
https://doaj.org/article/31a0e9274eda4838bb228557c7a3fc9d
Autor:
Krisztina K Johansen, Lei Wang, Jan O Aasly, Linda R White, Wayne R Matson, Claire Henchcliffe, M Flint Beal, Mikhail Bogdanov
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7551 (2009)
Mutations in LRRK2 gene represent the most common known genetic cause of Parkinson's disease (PD).We used metabolomic profiling to identify biomarkers that are associated with idiopathic and LRRK2 PD. We compared plasma metabolomic profiles of patien
Externí odkaz:
https://doaj.org/article/4307730a405e40edaf52680855cfdb51
Autor:
Lichuan Yang, Noel Y Calingasan, Bobby Thomas, Rajnish K Chaturvedi, Mahmoud Kiaei, Elizabeth J Wille, Karen T Liby, Charlotte Williams, Darlene Royce, Renee Risingsong, Eric S Musiek, Jason D Morrow, Michael Sporn, M Flint Beal
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5757 (2009)
The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway regulates phase 2 detoxification genes, including a variety of antioxidative enzymes. We tested neuroprotective effects of the synthetic triterpenoid CDDO-MA, a po
Externí odkaz:
https://doaj.org/article/7b065d494c1646bf872470a869ff8dc8
Autor:
Wencheng Liu, Cristofol Vives-Bauza, Rebeca Acín-Peréz, Ai Yamamoto, Yingcai Tan, Yanping Li, Jordi Magrané, Mihaela A Stavarache, Sebastian Shaffer, Simon Chang, Michael G Kaplitt, Xin-Yun Huang, M Flint Beal, Giovanni Manfredi, Chenjian Li
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4597 (2009)
Mutations in PTEN induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. Here, we report that PINK1 exists as a dimer in mitochondrial protein complexes that co-migrate with res
Externí odkaz:
https://doaj.org/article/852a8703ec6941798c2d544d3cb17f23
Autor:
Cecile Martinat, Shoshana Shendelman, Alan Jonason, Thomas Leete, M Flint Beal, Lichuan Yang, Thomas Floss, Asa Abeliovich
Publikováno v:
PLoS Biology, Vol 2, Iss 11, p e327 (2004)
The hallmark of Parkinson's disease (PD) is the selective loss of dopamine neurons in the ventral midbrain. Although the cause of neurodegeneration in PD is unknown, a Mendelian inheritance pattern is observed in rare cases, indicating a genetic fact
Externí odkaz:
https://doaj.org/article/31721bec296f4de0bc37b33e4b2b598a