Zobrazeno 1 - 10
of 33
pro vyhledávání: '"M F Moffatt"'
Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium.
Autor:
J M Vonk, S Scholtens, D S Postma, M F Moffatt, D Jarvis, A Ramasamy, M Wjst, E R Omenaas, E Bouzigon, F Demenais, R Nadif, V Siroux, A V Polonikov, M Solodilova, V P Ivanov, I Curjuric, M Imboden, A Kumar, N Probst-Hensch, L M Ogorodova, V P Puzyrev, E Yu Bragina, M B Freidin, I M Nolte, A M Farrall, W O C M Cookson, D P Strachan, G H Koppelman, H M Boezen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172716 (2017)
BACKGROUND:Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smok
Externí odkaz:
https://doaj.org/article/496346024af446f4a8ef3bcdbd0b4d4b
Autor:
M. van Hage-Hamsten, M. Kronqvist, A. Loughry, Eva Johansson, M. F. Moffatt, W. O. C. M. Cookson
Publikováno v:
Clinical & Experimental Allergy. 32:838-842
Summary Background Polymorphisms within the β subunit of the high-affinity receptor for IgE (FceR1-β) on chromosome 11q13 have been related to atopy and asthma and the lymphotoxin α (LTα) gene on chromosome 6 is implicated in asthma. Objective To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4606d0be07d98075e903cec8a43bbab2
https://doi.org/10.1046/j.1365-2222.2002.01402.x
https://doi.org/10.1046/j.1365-2222.2002.01402.x
Publikováno v:
Thorax. 54:757-761
BACKGROUND Tumour necrosis factor (TNF) is a potent pro-inflammatory cytokine which is prominent in asthmatic airways. TNF shows genetic variations in secretion which are linked to polymorphisms in the TNF gene complex and the surrounding major histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee31946e0995d017feb4e09a02e53ab
https://doi.org/10.1136/thx.54.9.757
https://doi.org/10.1136/thx.54.9.757
Autor:
William O.C.M. Cookson, J. A. Faux, Marie-Hélène Dizier, Florence Demenais, Arthur W. Musk, M. F. Moffatt, Alan L. James
Publikováno v:
Genetic Epidemiology. 16:305-315
Segregation analysis of the specific response to allergens (SRA) was performed in a sample of 234 randomly selected Australian families using the regressive models. Various SRA phenotypes were considered using broad and narrow definitions of these ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6231d511f48366ae2c94916eab02d910
https://doi.org/10.1002/(sici)1098-2272(1999)16:3<305::aid-gepi6>3.0.co
https://doi.org/10.1002/(sici)1098-2272(1999)16:3<305::aid-gepi6>3.0.co
Autor:
William O.C.M. Cookson, M. F. Moffatt
Publikováno v:
Clinical & Experimental Allergy. 28:56-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4157c03b0f7b159afa456b38dcdc1bae
https://doi.org/10.1046/j.1365-2222.1998.0280s1056.x
https://doi.org/10.1046/j.1365-2222.1998.0280s1056.x
Autor:
J. A. Faux, R. Coleman, William O.C.M. Cookson, H. E. Cox, M. F. Moffatt, Richard C. Trembath, John I. Harper, Andrew Walley
Publikováno v:
British Journal of Dermatology. 138:182-187
IgE dysregulation is a major pathogenic feature of atopic dermatitis and other IgE-mediated allergic diseases such as asthma and rhinitis. Allergen complexed to IgE binds to the high affinity receptor for IgE (Fc epsilon RI) on the surface of epiderm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0268594c8f4a505a2b099e60c89541a2
https://doi.org/10.1046/j.1365-2133.1998.02108.x
https://doi.org/10.1046/j.1365-2133.1998.02108.x
Publikováno v:
Immunogenetics. 46:226-230
Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25805d638c8b9569bc01d81154b3d889
https://doi.org/10.1007/s002510050266
https://doi.org/10.1007/s002510050266
Autor:
M. Gracey, Arthur W. Musk, William O.C.M. Cookson, P.N. LeSouëf, P.R. Bremner, E. Mockford, J. A. Faux, S.E. Daniels, P.D. Paré, R. Spargo, M. F. Moffatt, Lyle J. Palmer
Publikováno v:
The American Journal of Human Genetics. 61:182-188
Endemic helminthic infection is a major public-health problem and affects a large proportion of the world's population. In Australia, helminthic infection is endemic in Aboriginal communities living in tropical northern regions of the continent. Such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4a201ed73ab912637d996818aea46a
https://doi.org/10.1086/513888
https://doi.org/10.1086/513888
Autor:
A. Lalvani, William O.C.M. Cookson, J. A. Faux, J. W. Dekker, David A. Warrell, M. F. Moffatt
Publikováno v:
Clinical Experimental Allergy. 27:578-583
Summary Background Stings from bees and wasps can cause systemic reactions which can be fatal in some individuals. In these venom-sensitive patients, specific IgE to the venom is produced and is considered to participate in the adverse reactions. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a70540e65094a75aa634dac6cb20e9f
https://doi.org/10.1046/j.1365-2222.1997.450851.x
https://doi.org/10.1046/j.1365-2222.1997.450851.x
Autor:
William O.C.M. Cookson, M. F. Moffatt
Publikováno v:
Human Molecular Genetics. 6:551-554
Airway inflammation is a prominent feature of asthma. The pro-inflammatory cytokine Tumour Necrosis Factor shows constitutional variation in its level of secretion, which is linked to polymorphisms within the TNF gene complex and the surrounding MHC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe5a46d0f5ecf6156edab1d22e70d2b
https://doi.org/10.1093/hmg/6.4.551
https://doi.org/10.1093/hmg/6.4.551