Zobrazeno 1 - 10 of 62 pro vyhledávání: '"M F Goodman"'
1
Absence of a role for DNA polymerase II in SOS-induced translesion bypass of phi X174
Autor: G Faundez, Susan S. Wallace, M F Goodman, Yoke Wah Kow, S Hays, C A Bonner
Publikováno v: Journal of Bacteriology. 175:561-564
In order to examine the possible role of Escherichia coli DNA polymerase II in SOS-induced translesion bypass, Weigle reactivation and mutation induction were measured with single-stranded phi X174 transfecting DNA containing individual lesions. No d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48f1fdaba11bb61eb2ed70c9ddf5384
https://doi.org/10.1128/jb.175.2.561-564.1993
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3
Specificity and enzymatic mechanism of the editing exonuclease of Escherichia coli DNA polymerase III
Autor: Stephan D. Brenowitz, M. F. Goodman, M O'Donnell, Harrison Echols, S Kwack
Publikováno v: Journal of Biological Chemistry. 266:7888-7892
Exonucleolytic editing is a major contributor to the fidelity of DNA replication by the multisubunit DNA polymerase (pol) III holoenzyme. To investigate the source of editing specificity, we have studied the isolated exonuclease subunit, epsilon, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a230389cf65e84a605a36151f2f6112
https://doi.org/10.1016/s0021-9258(20)89533-7
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4
Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus
Autor: L F, Silvian, E A, Toth, P, Pham, M F, Goodman, T, Ellenberger
Publikováno v: Nature structural biology. 8(11)
A new group of error-prone DNA polymerases overcomes the blockage posed to normal DNA replication by damaged template bases, suggesting an active site with a loose, flexible pocket that accommodates aberrant DNA structures. We have determined a 2.8 A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22e2368c0123b205e6f4bf5b8d474427
https://pubmed.ncbi.nlm.nih.gov/11685247
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5
Molecular mechanism and energetics of clamp assembly in Escherichia coli. The role of ATP hydrolysis when gamma complex loads beta on DNA
Autor: J G, Bertram, L B, Bloom, M M, Hingorani, J M, Beechem, M, O'Donnell, M F, Goodman
Publikováno v: The Journal of biological chemistry. 275(37)
Escherichia coli DNA polymerase III holoenzyme is a multisubunit composite containing the beta sliding clamp and clamp loading gamma complex. The gamma complex requires ATP to load beta onto DNA. A two-color fluorescence spectroscopic approach was ut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ef539fd134d45141c96fd72fe923bc1
https://pubmed.ncbi.nlm.nih.gov/10874049
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6
A model for Escherichia coli DNA polymerase III holoenzyme assembly at primer/template ends. DNA triggers a change in binding specificity of the gamma complex clamp loader
Autor: B, Ason, J G, Bertram, M M, Hingorani, J M, Beechem, M, O'Donnell, M F, Goodman, L B, Bloom
Publikováno v: The Journal of biological chemistry. 275(4)
The gamma complex of the Escherichia coli DNA polymerase III holoenzyme assembles the beta sliding clamp onto DNA in an ATP hydrolysis-driven reaction. Interactions between gamma complex and primer/template DNA are investigated using fluorescence dep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88afd1d1bf5068749ad4438524d3bf2f
https://pubmed.ncbi.nlm.nih.gov/10644772
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7
'Action-at-a-distance' mutagenesis. 8-oxo-7, 8-dihydro-2'-deoxyguanosine causes base substitution errors at neighboring template sites when copied by DNA polymerase beta
Autor: E, Efrati, G, Tocco, R, Eritja, S H, Wilson, M F, Goodman
Publikováno v: The Journal of biological chemistry. 274(22)
8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG), a common oxidative DNA lesion, favors a syn-conformation in DNA, enabling formation of stable 8-oxo-dG.A base mispairs resulting in G.C --T.A transversion mutations. When human DNA polymerase (pol) beta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7bbb744f7c46e7bb91b1d69f0b14281
https://pubmed.ncbi.nlm.nih.gov/10336498
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8
Relevance of 'adaptive' mutations arising in non-dividing cells of microorganisms to age-related changes in mutant phenotypes of neurons
Autor: C E, Finch, M F, Goodman
Publikováno v: Trends in neurosciences. 20(11)
Brattleboro rats do not produce vasopressin (VP) because of a germ-line single-base deletion (di) that causes a frame shift downstream from the VP sequences and a loss of a stop codon. The resulting frame-shifted peptide precursor does not enter the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b767a8dbe087b2a7a0c1ca748b6c8b
https://pubmed.ncbi.nlm.nih.gov/9364662
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9
Fidelity of Escherichia coli DNA polymerase III holoenzyme. The effects of beta, gamma complex processivity proteins and epsilon proofreading exonuclease on nucleotide misincorporation efficiencies
Autor: L B, Bloom, X, Chen, D K, Fygenson, J, Turner, M, O'Donnell, M F, Goodman
Publikováno v: The Journal of biological chemistry. 272(44)
The fidelity of Escherichia coli DNA polymerase III (pol III) is measured and the effects of beta, gamma processivity and epsilon proofreading subunits are evaluated using a gel kinetic assay. Pol III holoenzyme synthesizes DNA with extremely high fi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd942a313118dbe8db154488e0b2c857
https://pubmed.ncbi.nlm.nih.gov/9346941
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