Zobrazeno 1 - 9 of 9 pro vyhledávání: '"M F Boehm"'
1
Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activity
Autor: Hugh Rosen, M F Boehm, Fiona Scott, J. Brooks, H. Desale, R. Powell, E. Brahmachary, E. Martinborough, H. Dedman, Robert Peach, Edward Roberts, G A Timony, Bryan Clemons
Publikováno v: British Journal of Pharmacology. 173:1778-1792
Background and Purpose Sphingosine1-phosphate (S1P) receptors mediate multiple events including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Stimulation of S1P1 receptors sequesters lymphocyte subsets in peripheral lym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::878343df5d52f1179fc3f87a9a3fdfb0
https://doi.org/10.1111/bph.13476
Zobrazit plný text záznamu
2
A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice
Autor: D R, Shalinsky, E D, Bischoff, W W, Lamph, L, Zhang, M F, Boehm, P J, Davies, A M, Nadzan, R A, Heyman
Publikováno v: Cancer research. 57(1)
We have identified a novel retinoid, ALRT1550, that potently and selectively activates retinoic acid receptors (RARs). ALRT1550 binds RARs with Kd values of approximately equal to 1-4 nM, and retinoid X receptors with low affinities (Kd approximately
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ff342854b43cd0ac4d667d089f4cc0f
https://pubmed.ncbi.nlm.nih.gov/8988059
Zobrazit plný text záznamu
3
Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate
Autor: M A, Shirley, Y L, Bennani, M F, Boehm, A P, Breau, C, Pathirana, E H, Ulm
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(3)
9-cis-Retinoic acid (9-cis-RA), a hormone that binds and activates all known retinoid receptor subtypes, is structurally similar to all-trans-retinoic acid and may share common metabolic fates. Both oral and intravenous doses of 9-cis-RA to rats led
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e96d62e5cda8b46e9a213c6489e22fc3
https://pubmed.ncbi.nlm.nih.gov/8820419
Zobrazit plný text záznamu
4
Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells
Autor: C Suto, Ana Angulo, R A Heyman, Peter Ghazal, M F Boehm
Publikováno v: Europe PubMed Central
Angulo, A, Suto, C, Boehm, M F, Heyman, R A & Ghazal, P 1995, ' Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells ', Journal of Virology, vol. 69, no. 6, pp. 3831-7 . < http://jvi.asm.org/content/69/6/3831 >
The susceptibility of human embryonal cell line NT-2/D1 to replicate human cytomegalovirus (hCMV) is dependent on retinoic acid (RA) stimulation. Physiological responses to retinoic acid involve two distinct subfamilies of nuclear receptors, the RA r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9d941f9cb519892b60d5d30f325827
https://europepmc.org/articles/PMC189101/
Zobrazit plný text záznamu
5
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties
Autor: M F, Boehm, M R, McClurg, C, Pathirana, D, Mangelsdorf, S K, White, J, Hebert, D, Winn, M E, Goldman, R A, Heyman
Publikováno v: Journal of medicinal chemistry. 37(3)
all-trans-Retinoic acid is known to bind to the retinoic acid receptors (RARs) resulting in an increase in their transcriptional activity. In contrast, recently identified 9-cis-retinoic acid (9-cis-RA), which is an additional endogenous RA isomer, i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0566e92484f1c02d940d87c1baf9727
https://pubmed.ncbi.nlm.nih.gov/8308867
Zobrazit plný text záznamu
6
Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism
Autor: E A, Allegretto, M R, McClurg, S B, Lazarchik, D L, Clemm, S A, Kerner, M G, Elgort, M F, Boehm, S K, White, J W, Pike, R A, Heyman
Publikováno v: The Journal of biological chemistry. 268(35)
The binding affinities of 9-cis-retinoic acid (9-cis-RA) and all-trans-retinoic acid (t-RA) for retinoic acid receptors (RAR) alpha, beta, and gamma and for retinoid X receptors (RXR) alpha, beta, and gamma were determined using the recombinant recep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cfb820051ab804e859e3851a8dd1d2e
https://pubmed.ncbi.nlm.nih.gov/8253793
Zobrazit plný text záznamu
9
Investigations of in vivo methionine racemization in mammalian tissues
Autor: M F, Boehm, J L, Bada
Publikováno v: Biochemistry international. 8(5)
The racemization rate of methionine at pH 7.4 and 100 degrees C was determined to be similar to that of aspartic acid. However, analyses of dentin and ocular lens nucleus samples from known age Rhesus monkeys showed that unlike aspartic acid, methion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::815fce5eef990b8abf467825620f468c
https://pubmed.ncbi.nlm.nih.gov/6477622
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje