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Depletion in the levels of the release factor eRF1 causes a reduction in the efficiency of translation termination in yeast

Autor: I, Stansfield, L, Eurwilaichitr, Akhmaloka, M F, Tuite

Publikováno v: Molecular Microbiology. 20:1135-1143

Summary In Saccharomyces cerevisiae, translation termination is mediated by a complex of two proteins, eRF1 and eRF3, encoded by the SUP45and SUP35 genes, respectively. Mutations in the SUP45 gene were selected which enhanced suppression by the weak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d927add259acc40f8bb08f75ad4bdcd3
https://doi.org/10.1111/j.1365-2958.1996.tb02634.x

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Estimating the number of prions in yeast cells

Autor: D J, Cole, B J T, Morgan, M S, Ridout, L J, Byrne, M F, Tuite

Publikováno v: Mathematical medicine and biology : a journal of the IMA. 21(4)

Certain yeast cells contain proteins that behave like the mammalian prion PrP and are called yeast prions. The yeast prion protein Sup35p can exist in one of two stable forms, giving rise to phenotypes [PSI(+)] and [psi(-)]. If the chemical guanidine

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https://pubmed.ncbi.nlm.nih.gov/15567890

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Seryl-tRNA synthetase is not responsible for the evolution of CUG codon reassignment in Candida albicans

Autor: J M, O'Sullivan, M J, Mihr, M A, Santos, M F, Tuite

Publikováno v: Yeast (Chichester, England). 18(4)

A number of Candida species translate the standard leucine-CUG codon as serine using a novel ser-tRNA(CAG). This tRNA, which has an unusual anticodon stem-loop structure, has been implicated in the evolution of this codon reassignment. However, such

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https://pubmed.ncbi.nlm.nih.gov/11223940

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Translation termination and its regulation in eukaryotes: recent insights provided by studies in yeast

Autor: P, Mugnier, M F, Tuite

Publikováno v: Biochemistry. Biokhimiia. 64(12)

In protein synthesis, the arrival of one or other of the three stop codons in the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In eukaryotes, the RF is composed of two protei

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https://pubmed.ncbi.nlm.nih.gov/10648959

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The Candida albicans CUG-decoding ser-tRNA has an atypical anticodon stem-loop structure

Autor: V M, Perreau, G, Keith, W M, Holmes, A, Przykorska, M A, Santos, M F, Tuite

Publikováno v: Journal of molecular biology. 293(5)

In many Candida species, the leucine CUG codon is decoded by a tRNA with two unusual properties: it is a ser-tRNA and, uniquely, has guanosine at position 33 (G33). Using a combination of enzymatic (V1 RNase, RnI nuclease) and chemical (Pb(2+), imida

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https://pubmed.ncbi.nlm.nih.gov/10547284

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The versatility of RNA structure and function. Jacques Monod Conference: New insights into the mechanism of mRNA translation: the significance of RNA structure, Aussois, France, 22-26 March 1999

Autor: P, Linder, M F, Tuite

Publikováno v: Trends in genetics : TIG. 15(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b510915123017130c88c90a57cc8d93d
https://pubmed.ncbi.nlm.nih.gov/10475856

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Living resources for biotechnology. Yeasts Edited by B. E. Kirsop & C. P. Kurtzman (in collaboration with T. Nakase & D. Yarrow), Cambridge University Press, Cambridge, UK, 1988. pp. 234, price £15.00. ISBN 0-521-35227-4

Autor: M. F. Tuite

Publikováno v: Journal of Chemical Technology & Biotechnology. 47:86-87

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a0ed4f94e34e43ce60b09e4cc85ac19
https://doi.org/10.1002/jctb.280470112

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Transfer RNA structural change is a key element in the reassignment of the CUG codon in Candida albicans

Autor: M A, Santos, V M, Perreau, M F, Tuite

Publikováno v: The EMBO journal. 15(18)

The human pathogenic yeast Candida albicans and a number of other Candida species translate the standard leucine CUG codon as serine. This is the latest addition to an increasing number of alterations to the standard genetic code which invalidate the

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https://pubmed.ncbi.nlm.nih.gov/8890179

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Preparation and use of yeast cell-free translation lysate

Autor: A D, Hartley, M A, Santos, D R, Colthurst, M F, Tuite

Publikováno v: Methods in molecular biology (Clifton, N.J.). 53

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https://pubmed.ncbi.nlm.nih.gov/8924986

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Translation elongation factor-3 (EF-3): an evolving eukaryotic ribosomal protein?

Autor: G P, Belfield, N J, Ross-Smith, M F, Tuite

Publikováno v: Journal of molecular evolution. 41(3)

Fungi appear to be unique in their requirement for a third soluble translation elongation factor. This factor, designated elongation factor 3 (EF-3), exhibits ribosome-dependent ATPase and GTPase activities that are not intrinsic to the fungal riboso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d4866ca12dbcd8e151ef1066cd38384
https://pubmed.ncbi.nlm.nih.gov/7563124

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