Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M F, Rafferty"'
Autor:
L Y, Hu, T R, Ryder, M F, Rafferty, K M, Siebers, T, Malone, A, Chatterjee, M R, Feng, S M, Lotarski, D M, Rock, S J, Stoehr, C P, Taylor, M L, Weber, G P, Miljanich, E, Millerman, B G, Szoke
Publikováno v:
Drug design and discovery. 17(1)
Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::382704345de2c1326eb0cae55033ad48
https://pubmed.ncbi.nlm.nih.gov/10928451
https://pubmed.ncbi.nlm.nih.gov/10928451
Autor:
T R, Ryder, L Y, Hu, M F, Rafferty, S M, Lotarski, D M, Rock, S J, Stoehr, C P, Taylor, M L, Weber, G P, Miljanich, E, Millerman, B G, Szoke
Publikováno v:
Drug design and discovery. 16(4)
Exploration of the SAR around the leucine side chain in a series of N,N-dialkyldipeptidylamines with potent functional activity at N-type VSCC is presented. A novel analog is disclosed which possesses improved aqueous solubility, in vivo activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::181b431799a8847399920bf609953e41
https://pubmed.ncbi.nlm.nih.gov/10807036
https://pubmed.ncbi.nlm.nih.gov/10807036
Autor:
L, Tam, M F, Rafferty
Publikováno v:
Receptor. 4(2)
In this study, the delta receptor-selective nonequilibrium affinity ligands, 5'-NTII and DALCE, and the nonspecific sulfhydryl reagent NEM were evaluated over a range of concentrations and treatment conditions for their ability to selectively alter t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c60b7e0eeadc449529bbd7046c3bd4f
https://pubmed.ncbi.nlm.nih.gov/7950982
https://pubmed.ncbi.nlm.nih.gov/7950982
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(2)
Spinal delta opioid receptors have been proposed to mediate antinociception in the rat on the basis of 1) the efficacy of a small number of agonists; 2) the lack of effect of mu-selective antagonists; and 3) the lack of cross-tolerance with mu-select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bee9a421289a928fbefbd34649299cb3
https://pubmed.ncbi.nlm.nih.gov/1658309
https://pubmed.ncbi.nlm.nih.gov/1658309
Autor:
E A, Harrison, M F, Rafferty, K C, Rice, C R, Creveling, G D, Winger, J H, Woods, A E, Jacobson
Publikováno v:
NIDA research monograph. 55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8dd46c7a56802a85cc644e9e6318a5d2
https://pubmed.ncbi.nlm.nih.gov/6100507
https://pubmed.ncbi.nlm.nih.gov/6100507
Autor:
A E, Jacobson, E A, Harrison, M V, Mattson, M F, Rafferty, K C, Rice, J H, Woods, G, Winger, R E, Solomon, R A, Lessor, J V, Silverton
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 243(1)
Dioxadrol exists in four isomeric forms. alpha-(+)-Dioxadrol (dexoxadrol) showed phencyclidine (PCP)-like activity in rhesus monkeys trained to discriminate s.c. administration of ketamine, but neither alpha-(-)-dioxadrol (levoxadrol) nor beta-(+/-)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4127680dcec2a460179fb23263cc1fd
https://pubmed.ncbi.nlm.nih.gov/2822892
https://pubmed.ncbi.nlm.nih.gov/2822892
Autor:
W, Koek, R, Head, E J, Holsztynska, J H, Woods, E F, Domino, A E, Jacobson, M F, Rafferty, K C, Rice, R A, Lessor
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 234(3)
Metaphit, a derivative of phencyclidine (PCP), irreversibly binds to PCP sites in rat brain homogenates. PCP-induced catalepsy in pigeons, which is a pharmacologically specific and stereoselective phenomenon, was used to study pharmacological consequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2733c5ae2b337670655b522756047a24
https://pubmed.ncbi.nlm.nih.gov/2993588
https://pubmed.ncbi.nlm.nih.gov/2993588
Publikováno v:
Life sciences. 31(10)
A series of analogues of dopamine (DA) with varying degrees of conformational flexibility have been examined as potential substrates or competitive inhibitors of the enzyme norepinephrine N-methyltransferase (NMT). A conformationally defined (rigid)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03ffa7140d84b8caefb3e6bd3bf6570f
https://pubmed.ncbi.nlm.nih.gov/7132559
https://pubmed.ncbi.nlm.nih.gov/7132559
Autor:
M F, Rafferty, G L, Grunewald
Publikováno v:
Molecular pharmacology. 22(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::466a7794477c4fadde1c61b0f67c63b5
https://pubmed.ncbi.nlm.nih.gov/7121446
https://pubmed.ncbi.nlm.nih.gov/7121446
Autor:
P C, Contreras, S, Johnson, R, Freedman, B, Hoffer, K, Olsen, M F, Rafferty, R A, Lessor, K C, Rice, A E, Jacobson, T L, O'Donohue
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 238(3)
Metaphit, which acylates phencyclidine (PCP) receptors in vitro, was shown to acylate PCP receptors and antagonize the behavioral and electrophysiological effects of PCP in vivo. Metaphit (2 mumol/rat) administered i.c.v. produced PCP-like stereotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4ba85a53424e5e12ffa1b62ac639733
https://pubmed.ncbi.nlm.nih.gov/3018219
https://pubmed.ncbi.nlm.nih.gov/3018219