Zobrazeno 1 - 10
of 92
pro vyhledávání: '"M F, Rafferty"'
Autor:
L Y, Hu, T R, Ryder, M F, Rafferty, K M, Siebers, T, Malone, A, Chatterjee, M R, Feng, S M, Lotarski, D M, Rock, S J, Stoehr, C P, Taylor, M L, Weber, G P, Miljanich, E, Millerman, B G, Szoke
Publikováno v:
Drug design and discovery. 17(1)
Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::382704345de2c1326eb0cae55033ad48
https://pubmed.ncbi.nlm.nih.gov/10928451
https://pubmed.ncbi.nlm.nih.gov/10928451
Autor:
T R, Ryder, L Y, Hu, M F, Rafferty, S M, Lotarski, D M, Rock, S J, Stoehr, C P, Taylor, M L, Weber, G P, Miljanich, E, Millerman, B G, Szoke
Publikováno v:
Drug design and discovery. 16(4)
Exploration of the SAR around the leucine side chain in a series of N,N-dialkyldipeptidylamines with potent functional activity at N-type VSCC is presented. A novel analog is disclosed which possesses improved aqueous solubility, in vivo activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::181b431799a8847399920bf609953e41
https://pubmed.ncbi.nlm.nih.gov/10807036
https://pubmed.ncbi.nlm.nih.gov/10807036
Autor:
L, Tam, M F, Rafferty
Publikováno v:
Receptor. 4(2)
In this study, the delta receptor-selective nonequilibrium affinity ligands, 5'-NTII and DALCE, and the nonspecific sulfhydryl reagent NEM were evaluated over a range of concentrations and treatment conditions for their ability to selectively alter t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c60b7e0eeadc449529bbd7046c3bd4f
https://pubmed.ncbi.nlm.nih.gov/7950982
https://pubmed.ncbi.nlm.nih.gov/7950982
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(2)
Spinal delta opioid receptors have been proposed to mediate antinociception in the rat on the basis of 1) the efficacy of a small number of agonists; 2) the lack of effect of mu-selective antagonists; and 3) the lack of cross-tolerance with mu-select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bee9a421289a928fbefbd34649299cb3
https://pubmed.ncbi.nlm.nih.gov/1658309
https://pubmed.ncbi.nlm.nih.gov/1658309
Publikováno v:
Chemical Communications; 8/14/2024, Vol. 60 Issue 63, p8224-8227, 4p
Autor:
E A, Harrison, M F, Rafferty, K C, Rice, C R, Creveling, G D, Winger, J H, Woods, A E, Jacobson
Publikováno v:
NIDA research monograph. 55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8dd46c7a56802a85cc644e9e6318a5d2
https://pubmed.ncbi.nlm.nih.gov/6100507
https://pubmed.ncbi.nlm.nih.gov/6100507
Autor:
A E, Jacobson, E A, Harrison, M V, Mattson, M F, Rafferty, K C, Rice, J H, Woods, G, Winger, R E, Solomon, R A, Lessor, J V, Silverton
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 243(1)
Dioxadrol exists in four isomeric forms. alpha-(+)-Dioxadrol (dexoxadrol) showed phencyclidine (PCP)-like activity in rhesus monkeys trained to discriminate s.c. administration of ketamine, but neither alpha-(-)-dioxadrol (levoxadrol) nor beta-(+/-)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4127680dcec2a460179fb23263cc1fd
https://pubmed.ncbi.nlm.nih.gov/2822892
https://pubmed.ncbi.nlm.nih.gov/2822892
Autor:
W, Koek, R, Head, E J, Holsztynska, J H, Woods, E F, Domino, A E, Jacobson, M F, Rafferty, K C, Rice, R A, Lessor
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 234(3)
Metaphit, a derivative of phencyclidine (PCP), irreversibly binds to PCP sites in rat brain homogenates. PCP-induced catalepsy in pigeons, which is a pharmacologically specific and stereoselective phenomenon, was used to study pharmacological consequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2733c5ae2b337670655b522756047a24
https://pubmed.ncbi.nlm.nih.gov/2993588
https://pubmed.ncbi.nlm.nih.gov/2993588
Publikováno v:
Life sciences. 31(10)
A series of analogues of dopamine (DA) with varying degrees of conformational flexibility have been examined as potential substrates or competitive inhibitors of the enzyme norepinephrine N-methyltransferase (NMT). A conformationally defined (rigid)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03ffa7140d84b8caefb3e6bd3bf6570f
https://pubmed.ncbi.nlm.nih.gov/7132559
https://pubmed.ncbi.nlm.nih.gov/7132559
Autor:
M F, Rafferty, G L, Grunewald
Publikováno v:
Molecular pharmacology. 22(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::466a7794477c4fadde1c61b0f67c63b5
https://pubmed.ncbi.nlm.nih.gov/7121446
https://pubmed.ncbi.nlm.nih.gov/7121446