Zobrazeno 1 - 10
of 63
pro vyhledávání: '"M F, Mescher"'
Autor:
R M Kedl, M F Mescher
Publikováno v:
The Journal of Immunology. 159:650-663
The response of CD8+ T cells to allogeneic tumor was studied by adoptive transfer of cells from TCR transgenic 2C mice specific for Ld alloantigen. Transferred cells were monitored during the course of a response to i.p. challenge with live P815 (H-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da70d677fd4dc050049f325dc28966c8
https://doi.org/10.4049/jimmunol.159.2.650
https://doi.org/10.4049/jimmunol.159.2.650
Publikováno v:
The Journal of Immunology. 157:2243-2246
It has been suggested that induction of phosphatidylinositol (PI) 3 kinase activity upon CD28 costimulation may contribute to CD28-mediated signaling. In this report, T cell stimulation by microspheres bearing coimmobilized anti-TCR mAb and purified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bcc5f06c992052596bec689e716dcff
https://doi.org/10.4049/jimmunol.157.6.2243
https://doi.org/10.4049/jimmunol.157.6.2243
Publikováno v:
The Journal of Immunology. 155:1039-1046
Binding of CTL to MHC class I or fibronectin is activated through TCR signaling. Once activated, CTL adhesion to MHC class I results in tyrosine phosphorylation of CTL substrates, phosphatidylinositol (PI) turnover, and degranulation. Although activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a3f9777fa77c190b22efd567073fa1e
https://doi.org/10.4049/jimmunol.155.3.1039
https://doi.org/10.4049/jimmunol.155.3.1039
Autor:
A M O'Rourke, M F Mescher
Publikováno v:
The Journal of Immunology. 152:4358-4367
Adhesion of CD8+ CTL to purified class I proteins has been shown to be regulated by the TCR: nonactivated CTL do not adhere to immobilized class I proteins (non-Ag), but adhesion becomes readily detectable upon treatment of the CTL with fluid-phase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04b946535d28b497c1d825fd9d31258
https://doi.org/10.4049/jimmunol.152.9.4358
https://doi.org/10.4049/jimmunol.152.9.4358
Autor:
K P Kane, M F Mescher
Publikováno v:
The Journal of Immunology. 150:4788-4797
Activation of CTL requires engagement of both the TCR and the CD8 coreceptor. Immobilized class I proteins and in vitro-formed peptide class I Ag complexes have been used to examine the relative contributions of TCR and CD8 to the adhesion and respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7c1f3c1d1727331c942c9094c1be65c
https://doi.org/10.4049/jimmunol.150.11.4788
https://doi.org/10.4049/jimmunol.150.11.4788
Autor:
M F Mescher
Publikováno v:
The Journal of Immunology. 149:2402-2405
Cell activation resulting from binding of receptors on one cell to ligands on another is governed by receptor affinities and by ligand concentrations. Effective ligand concentration is determined by its density on the cell surface, but receptor occup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::352f08be92904b7c80aed0229d25cb93
https://doi.org/10.4049/jimmunol.149.7.2402
https://doi.org/10.4049/jimmunol.149.7.2402
Autor:
J Rogers, M F Mescher
Publikováno v:
The Journal of Immunology. 149:269-276
Class I alloantigen incorporated into cell-size supported membranes provides an effective stimulus for in vitro stimulation of CTL responses. When alloantigen-bearing cell-size (5 microns) microspheres, termed large multivalent immunogen (LMI), were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b58ace0faf747bce86c869c17206e2d3
https://doi.org/10.4049/jimmunol.149.1.269
https://doi.org/10.4049/jimmunol.149.1.269
Publikováno v:
The Journal of Immunology. 147:36-41
Cloned cytotoxic T lymphocytes specifically bind to purified alloantigen that has been immobilized on a surface. When the time course was examined, it was found that binding reached a plateau level within about 1 h at 37 degrees C, at which time abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46bebadca098e89d6817effde1143548
https://doi.org/10.4049/jimmunol.147.1.36
https://doi.org/10.4049/jimmunol.147.1.36
Autor:
K P Kane, M F Mescher
Publikováno v:
The Journal of Immunology. 144:824-829
Although engagement of the TCR via antibody can be sufficient to trigger T cells, responses to Ag-bearing cells require additional "accessory" interactions in many cases. A method has been developed which allows preparation of surfaces bearing both p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b48d2f62ea0366c605131b3f68814d
https://doi.org/10.4049/jimmunol.144.3.824
https://doi.org/10.4049/jimmunol.144.3.824
Autor:
P L, Jensen, M F, Mescher
Publikováno v:
European journal of immunology. 31(12)
CD8 must be activated by signaling through the TCR in order to mediate CTL adhesion. Up-regulation of adhesion to class I protein is shown to be blocked by specific inhibitors of phosphoinositide 3-OH kinase (PI3-K), indicating a critical role for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b259f2ef9f64b3bb8e99773647f80d1
https://pubmed.ncbi.nlm.nih.gov/11745381
https://pubmed.ncbi.nlm.nih.gov/11745381