Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M F, Fromm"'
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells. Here we investigated the potentia
Externí odkaz:
https://doaj.org/article/1fa1f9ccb126405e919607390a00314c
Autor:
M. F. Fromm
Publikováno v:
European Journal of Clinical Investigation. 33:6-9
The ATP-binding cassette transporter P-glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P-glycoprotein-expressing cell lines, the generation of P-glycoprotein knockout mice as well as studies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41410ec2f2fad49752f25ff3e610999b
https://doi.org/10.1046/j.1365-2362.33.s2.4.x
https://doi.org/10.1046/j.1365-2362.33.s2.4.x
Publikováno v:
British journal of pharmacology. 165(6)
The coordinate activity of hepatic uptake transporters [e.g. organic anion transporting polypeptide 1B1 (OATP1B1)], drug-metabolizing enzymes [e.g. UDP-glucuronosyltransferase 1A1 (UGT1A1)] and efflux pumps (e.g. MRP2) is a crucial determinant of dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11cb370dfb8ad4d58f4c7880cabde65e
https://pubmed.ncbi.nlm.nih.gov/21923755
https://pubmed.ncbi.nlm.nih.gov/21923755
Publikováno v:
British journal of pharmacology. 163(3)
The organic cation transporters 1 (OCT1) and 2 (OCT2) mediate drug uptake into hepatocytes and renal proximal tubular cells, respectively. Multidrug and toxin extrusion protein 1 (MATE1) is a major component of subsequent export into bile and urine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2213767067e438e908e2d7cfa5b8099e
https://pubmed.ncbi.nlm.nih.gov/20883471
https://pubmed.ncbi.nlm.nih.gov/20883471
Publikováno v:
British journal of pharmacology. 159(3)
Organic anion transporting polypeptide 1B3 (OATP1B3) (SLCO1B3) mediates the uptake of endogenous substrates (e.g. estrone-3-sulphate) and drugs (e.g. pravastatin) from blood into hepatocytes. Structure-based modelling of OATP1B3 suggested that a pore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78a25ca68debc342cad86250bdeabd65
https://pubmed.ncbi.nlm.nih.gov/20100277
https://pubmed.ncbi.nlm.nih.gov/20100277
Autor:
M. F. Fromm, M. Gramatzki
Publikováno v:
Springer-Lehrbuch ISBN: 3540204148
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1e160f7e83b2d858a875787d6718e46
https://doi.org/10.1007/3-540-35149-3_10
https://doi.org/10.1007/3-540-35149-3_10
Autor:
M F, Fromm
Publikováno v:
MMW Fortschritte der Medizin. 143(51-52)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f8cd096ea82dbdb945efbb00a76f54b
https://pubmed.ncbi.nlm.nih.gov/11824163
https://pubmed.ncbi.nlm.nih.gov/11824163
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(8)
Fexofenadine, a nonsedating antihistamine, does not undergo significant metabolic biotransformation. Accordingly, it was hypothesized that uptake and efflux transporters could be importantly involved in the drug's disposition. Utilizing a recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08d3a134e1e2f86fdeb712d84887b4be
https://pubmed.ncbi.nlm.nih.gov/10421612
https://pubmed.ncbi.nlm.nih.gov/10421612
Autor:
R B, Kim, C, Wandel, B, Leake, M, Cvetkovic, M F, Fromm, P J, Dempsey, M M, Roden, F, Belas, A K, Chaudhary, D M, Roden, A J, Wood, G R, Wilkinson
Publikováno v:
Pharmaceutical research. 16(3)
CYP3A and P-gp both function to reduce the intracellular concentration of drug substrates, one by metabolism and the other by transmembrane efflux. Moreover, it has been serendipitously noted that the two proteins have many common substrates and inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::383b952b116d687f29775f7c2232b3e3
https://pubmed.ncbi.nlm.nih.gov/10213372
https://pubmed.ncbi.nlm.nih.gov/10213372
Publikováno v:
Biochimica et biophysica acta. 1415(2)
In humans, at least six members of the multidrug resistance-associated protein (MRP) family are thought to exist. Here we report the molecular cloning of two splice variants of MRP3 from human liver. In addition, MRP3 genomic organization including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1234d9619b528e6f6af7da084895eca
https://pubmed.ncbi.nlm.nih.gov/9889399
https://pubmed.ncbi.nlm.nih.gov/9889399