Zobrazeno 1 - 4
of 4
pro vyhledávání: '"M F, Brackeen"'
Autor:
J. A. Menius, L. S. Noel, D P Yarnall, L. Sekut, K M Connolly, M. F. Brackeen, R. L. Clark, Stephen A. Stimpson, R. Bateman-Fite
SUMMARY Inhibitors of cyclic nucleotide phosphodiesterases are known to suppress lipopolysaccharide (LPS)-induced tumour necrosis factor-alpha (TNF-α) production in vitro in human monocytes. The most potent of these have selectivity for type IV PDEs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3dc2c3ef7a792cac994fadbfa7e1f0
Publikováno v:
The Journal of laboratory and clinical medicine. 124(6)
Elevated tumor necrosis factor (TNF) levels have been reported in various models of acute and chronic inflammation and used by many investigators to determine the stage of disease and effectiveness of treatment. Because of the documented involvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4817b5e54d58a9a7f4a2bbe4e0d774df
https://pubmed.ncbi.nlm.nih.gov/7798795
https://pubmed.ncbi.nlm.nih.gov/7798795
Autor:
M W, Lutz, P H, Morgan, M K, James, P L, Feldman, M F, Brackeen, A P, Lahey, S V, James, J M, Bilotta, J C, Pressley
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(2)
A simple mathematical model of analgesia in the rat is developed and utilized to determine quantitative structure-activity relationships for a series of novel 4-anilidopiperidine opioids. The compounds tested (selected alkyl carboxyethyl esters attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09162fc4202b30cfa9d52e5ca23f9a29
https://pubmed.ncbi.nlm.nih.gov/7965798
https://pubmed.ncbi.nlm.nih.gov/7965798
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(2)
GI 87084B (3-[4-methoxycarbonyl-4-[(1-oxopropyl) phenylamino]1-piperidine]propanoic acid, methyl ester, hydrochloride) was found to be a potent opioid agonist in the guinea pig ileum (EC50 = 2.4 +/- 0.6 nM), the rat vas deferens (EC50 = 387 +/- 44 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8db42cd1602391c459d79742fdf4290a
https://pubmed.ncbi.nlm.nih.gov/1658308
https://pubmed.ncbi.nlm.nih.gov/1658308