Zobrazeno 1 - 10
of 1 694
pro vyhledávání: '"M Eric Gershwin"'
Autor:
Ana Lleo, Zhaolian Bian, Haiyan Zhang, Qi Miao, Fang Yang, Yanshen Peng, Xiaoyu Chen, Ruqi Tang, Qixia Wang, Dekai Qiu, Jingyuan Fang, Cristina Sobacchi, Anna Villa, Luca Di Tommaso, Massimo Roncalli, M Eric Gershwin, Xiong Ma, Pietro Invernizzi
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0159612 (2016)
There is substantial data that suggests an abnormality of innate immunity in patients with primary biliary cholangitis (PBC) which includes the transcription factor nuclear factor-kB (NF-kB) and well as downstream inflammatory signaling pathways. In
Externí odkaz:
https://doaj.org/article/af649ad608844ecf960fde8208d0c50c
Autor:
Hao-Xian Zhu, Shu-Han Yang, Cai-Yue Gao, Zhen-Hua Bian, Xiao-Min Chen, Rong-Rong Huang, Qian-Li Meng, Xin Li, Haosheng Jin, Koichi Tsuneyama, Ying Han, Liang Li, Zhi-Bin Zhao, M. Eric Gershwin, Zhe-Xiong Lian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12b-/-Il2ra-/- mice (DKO mice) as a model of autoimmune cholangit
Externí odkaz:
https://doaj.org/article/a3208583c2fb4b3fbee865627da0c7c2
Autor:
Chao-Hsuan Chang, Ying-Chun Chen, Weici Zhang, Patrick S C Leung, M Eric Gershwin, Ya-Hui Chuang
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121320 (2015)
Invariant natural killer T (iNKT) cells play complex roles in bridging innate and adaptive immunity by engaging with glycolipid antigens presented by CD1d. Our earlier work suggested that iNKT cells were involved in the initiation of the original los
Externí odkaz:
https://doaj.org/article/0d0cbb58ed824c7584e9c0ecd48aac68
Autor:
Zhuye Qin, Fangming Cheng, Mingming Zhang, Ruonan Qian, Hong Chen, Yaqin Zhao, Youtao Zhang, Yaping Dai, Chaochao Tang, Peng Jiang, Xiaoli Hua, Shen Li, Bing Zheng, Pin Yu, Xingjuan Shi, Suraj Timilsina, M. Eric Gershwin, Xiangdong Liu, Chungen Qian, Fang Qiu
Publikováno v:
Journal of Translational Autoimmunity, Vol 9, Iss , Pp 100262- (2024)
The detection of antimitochondrial antibodies (AMA) is the specific diagnostic marker for primary biliary cholangitis. Indeed, it is the most specific autoantibody in clinical autoimmunity, with a high titer directed response to the inner lipoyl doma
Externí odkaz:
https://doaj.org/article/bed632776dd44a1a8d275f737fae3f5e
Autor:
Wei Yang, Yuan Yao, Yan-Qing Yang, Fang-Ting Lu, Liang Li, Yin-Hu Wang, Takahiko Nakajima, Koichi Tsuneyama, William M Ridgway, M Eric Gershwin, Zhe-Xiong Lian
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105351 (2014)
IFN-γ is a signature Th1 cell associated cytokine critical for the inflammatory response in autoimmunity with both pro-inflammatory and potentially protective functions. IL-17A is the hallmark of T helper 17 (Th17) cell subsets, produced by γδT, C
Externí odkaz:
https://doaj.org/article/7b9e2cab18514d87b585017acf664a97
Autor:
Mingming Zhang, Zhuye Qin, Yexi Huang, Wenyan Tian, You Li, Chan Wang, Weifeng Zhao, Yaping Dai, Xingjuan Shi, M. Eric Gershwin, Xiong Ma, Meilin Wang, Xiangdong Liu, Weichang Chen, Fang Qiu
Publikováno v:
Journal of Translational Autoimmunity, Vol 8, Iss , Pp 100234- (2024)
The biliary epithelial cells release CC chemokine receptor 6 (CCR6) ligand 20 (CCL20), leading to recruitment of CCR6+ T cells and subsequent infiltration into the biliary epithelium in primary biliary cholangitis patients. Previous genome-wide multi
Externí odkaz:
https://doaj.org/article/24871d533857436dae4755344bbd8d9c
Autor:
Chan Wang, Zhuye Qin, Mingming Zhang, Yaping Dai, Luyao Zhang, Wenyan Tian, Yuhua Gong, Sufang Chen, Can Yang, Ping Xu, Xingjuan Shi, Weifeng Zhao, Suraj Timilsina, M. Eric Gershwin, Weichang Chen, Fang Qiu, Xiangdong Liu
Publikováno v:
Journal of Translational Autoimmunity, Vol 8, Iss , Pp 100239- (2024)
Objectives: Antibodies to gp210 and sp100 are specific and unique anti-nuclear autoantibodies (ANAs) associated with primary biliary cholangitis (PBC). Importantly the presence of anti-gp210 and anti-sp100 responses is indicative of poor clinical out
Externí odkaz:
https://doaj.org/article/49d41df47cb24219af7f218d24f695de
Autor:
Kazuhito Kawata, Masanobu Tsuda, Guo-Xiang Yang, Weici Zhang, Hajime Tanaka, Koichi Tsuneyama, Patrick Leung, Xiao-Song He, Stuart Knechtle, Aftab A Ansari, Ross L Coppel, M Eric Gershwin
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74225 (2013)
Primary biliary cirrhosis (PBC) is considered a model autoimmune disease, with the most highly directed and specific autoantibody in both murine and human autoimmunity, the anti-mitochondrial autoantibody (AMA). However, therapeutic advances in this
Externí odkaz:
https://doaj.org/article/071b3f16f31142db9ffa468902ca6751
Autor:
Weici Zhang, Masanobu Tsuda, Guo-Xiang Yang, Koichi Tsuneyama, Xiao-Song He, Aftab A Ansari, William M Ridgway, Ross L Coppel, Zhe-Xiong Lian, Patrick S C Leung, M Eric Gershwin
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49413 (2012)
Hepatosplenic T cell lymphoma (HSTCL) is a distinct and lethal subtype of peripheral T cell lymphoma with an aggressive course and poor outcome despite multiagent chemotherapy. Contradictory literature, an unknown etiology, and poor response to treat
Externí odkaz:
https://doaj.org/article/7b03efe4b1a14809b9eb075c696fbe37
Autor:
You Li, Lu Zhou, Zuxiong Huang, Yue Yang, Jiming Zhang, Ling Yang, Yun Xu, Junping Shi, Shanhong Tang, Xiaoling Yuan, Jie Xu, Yiling Li, Xu Han, Jia Li, Yanmin Liu, Ying Sun, Xiaozhi Jin, Xiao Xiao, Bangmao Wang, Qiuxiang Lin, Yang Zhou, Xuejiao Song, Yong Cui, Lilin Hu, Yuhu Song, Jie Bao, Ling Gong, M. Eric Gershwin, Xianbo Zuo, Huiping Yan, Zhengsheng Zou, Ruqi Tang, Xiong Ma
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100926- (2024)
Background & Aims: Association studies have greatly refined the important role of the major histocompatibility complex (MHC) region in autoimmune hepatitis (AIH). However, the effects of human leucocyte antigen (HLA) polymorphisms on AIH are not well
Externí odkaz:
https://doaj.org/article/dbd42b753548473c859fa92dc5c5cb33