Zobrazeno 1 - 10
of 352
pro vyhledávání: '"M Eileen Dolan"'
Publikováno v:
Pharmacogenomics and Personalized Medicine, Vol 2008, Iss default, Pp 7-14 (2008)
Wei Zhang, R Stephanie Huang, M Eileen DolanSection of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USAAbstract: The goal of personalized medicine is to recommend drug treatment based on an individual’s
Externí odkaz:
https://doaj.org/article/5d7da38f70ce46f0ac959ab72d27709f
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118020 (2015)
There are no effective agents to prevent or treat chemotherapy-induced peripheral neuropathy (CIPN), the most common non-hematologic toxicity of chemotherapy. Therefore, we sought to evaluate the utility of human neuron-like cells derived from induce
Externí odkaz:
https://doaj.org/article/6235d08d74db478784db5f2705f75865
Autor:
Amy L Stark, Ronald J Hause, Lidija K Gorsic, Nirav N Antao, Shan S Wong, Sophie H Chung, Daniel F Gill, Hae K Im, Jamie L Myers, Kevin P White, Richard Baker Jones, M Eileen Dolan
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004192 (2014)
Annotating and interpreting the results of genome-wide association studies (GWAS) remains challenging. Assigning function to genetic variants as expression quantitative trait loci is an expanding and useful approach, but focuses exclusively on mRNA r
Externí odkaz:
https://doaj.org/article/d70e8f5d77ad47efb599e099fdb8de61
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82220 (2013)
Cisplatin, a commonly used chemotherapeutic, is associated with ototoxicity, renal toxicity and neurotoxicity, thus identifying means to increase the therapeutic index of cisplatin may allow for improved outcomes. A SNP (rs4343077) within EPS8, disco
Externí odkaz:
https://doaj.org/article/1f9bbadbb5ef4122a12673d49cc2f486
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002525 (2012)
The International HapMap project has made publicly available extensive genotypic data on a number of lymphoblastoid cell lines (LCLs). Building on this resource, many research groups have generated a large amount of phenotypic data on these cell line
Externí odkaz:
https://doaj.org/article/171a297623124dcdb540e3e8c08efc7e
Autor:
Younghee Lee, Eric R Gamazon, Ellen Rebman, Yeunsook Lee, Sanghyuk Lee, M Eileen Dolan, Nancy J Cox, Yves A Lussier
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1002998 (2012)
DNA variants that affect alternative splicing and the relative quantities of different gene transcripts have been shown to be risk alleles for some Mendelian diseases. However, for complex traits characterized by a low odds ratio for any single contr
Externí odkaz:
https://doaj.org/article/172d20423bbf4bd9b9db494604ef46d7
Autor:
Heather E Wheeler, Lidija K Gorsic, Marleen Welsh, Amy L Stark, Eric R Gamazon, Nancy J Cox, M Eileen Dolan
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21920 (2011)
Chemotherapeutic agents are used in the treatment of many cancers, yet variable resistance and toxicities among individuals limit successful outcomes. Several studies have indicated outcome differences associated with ancestry among patients with var
Externí odkaz:
https://doaj.org/article/ffe6859f30e64a0eb70be25a841a6a2e
Autor:
Eric R Gamazon, Hae-Kyung Im, Shiwei Duan, Yves A Lussier, Nancy J Cox, M Eileen Dolan, Wei Zhang
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13534 (2010)
Variation in gene expression has been observed in natural populations and associated with complex traits or phenotypes such as disease susceptibility and drug response. Gene expression itself is controlled by various genetic and non-genetic factors.
Externí odkaz:
https://doaj.org/article/345457e9fffc496f8711cb6f716e29db
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000888 (2010)
Although genome-wide association studies (GWAS) of complex traits have yielded more reproducible associations than had been discovered using any other approach, the loci characterized to date do not account for much of the heritability to such traits
Externí odkaz:
https://doaj.org/article/fc3aca6fd6ec4a9aabd90395e72c946d
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9366 (2010)
Microarray gene expression data has been used in genome-wide association studies to allow researchers to study gene regulation as well as other complex phenotypes including disease risks and drug response. To reach scientifically sound conclusions fr
Externí odkaz:
https://doaj.org/article/8eacdc7dde3546b085cccc251b093ca5