Zobrazeno 1 - 10
of 79
pro vyhledávání: '"M E Parsons"'
Publikováno v:
British Journal of Pharmacology. 159:1608-1622
The definitive article can be found at: http://www3.interscience.wiley.com/ Copyright The British Pharmacological Society [Full text of this article is not available in the UHRA]
Publikováno v:
British Journal of Pharmacology. 160:615-626
Original article can be found at: http://www3.interscience.wiley.com/ Copyright Wiley [Full text of this article is not available in the UHRA]
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G315-G326
Diabetes affects many aspects of gastrointestinal motility, in part due to changes in interstitial cells of Cajal (ICC). The effect of diabetes on the colon, however, is not well characterized, and the aim of the present study was to investigate poss
Autor:
A. Garner, M. E. Parsons
Publikováno v:
Alimentary Pharmacology & Therapeutics. 9:457-463
Rationalization within the pharmaceutical industry to combat escalating costs has included the close examination of research portfolios. Gastroenterology has been one of the casualties of this exercise and few companies currently retain a specific ga
Autor:
C. Robin Ganellin, M. E. Parsons
Publikováno v:
British Journal of Pharmacology. 147:S127-S135
This article reviews the development of our knowledge of the actions of histamine which have taken place during the course of the 20th century. Histamine has been shown to have a key physiological role in the control of gastric acid secretion and a p
Autor:
Dirk G. Demuth, M. E. Parsons, Rutger M. van Ree, E Gkoumassi, Johan Zaagsma, Bart G. J. Dekkers, Henk J. Esselink, S. Ad Nelemans, A Molleman, Melloney J. Dröge
Publikováno v:
Journal of Cellular Physiology, 205(1), 58-67. Wiley
Cannabinoid CB1-receptor stimulation in DDT1 MF-2 smooth muscle cells induces a rise in [Ca2+](i), which is dependent on extracellular Ca2+ and modulated by thapsigargin-sensitive stores, suggesting capacitative Ca2+ entry (CCE), and by MAP kinase. N
Publikováno v:
European Journal of Pharmacology. 509:77-83
Studies were performed to see if alterations in Ca2+ homeostasis underlie the gastrointestinal motility complications seen in many diabetic patients. Experiments were performed on colonic and ileal tissues taken from streptozotocin-induced diabetic a
Autor:
C. R. Ganellin, M. E. Parsons
Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instan
Autor:
A. Forrest, M. E. Parsons
Publikováno v:
Autonomic and Autacoid Pharmacology. 23:149-158
Summary 1 Approximately 45% of patients with diabetes mellitus have gastrointestinal complications such as diarrhoea and constipation, but the underlying aetiology is unclear. The present study investigates alterations in spontaneous motility of the
Publikováno v:
Life Sciences. 72:2091-2094
In the present study we have used RT-PCR to investigate nicotinic acetylcholine receptor (nAChR) subunit expression, and studied the effect of nicotine on TNFalpha-induced cytokine (IL-8) release in the epithelial cell line HT29. RNA was extracted us