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Autor:
L. Fiocchi, G. Pezzoni, C. E. Gallagher, E. Menta, A. P. Krapcho, M E Maresch, S. Spinelli, Miles P. Hacker, R. Di Domenico, F. C. Giuliani, Ambrogio Oliva, Gino Beggiolin
Publikováno v:
Journal of Medicinal Chemistry. 41:5429-5444
The synthesis and antitumor evaluation of 2, 5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-APs) are described. The key intermediates in the synthesis are benz[g]isoquinoline-5,10-diones which are substituted at positions 6 and 9 with